A5014463486- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Biochemical Acid Research Studies
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Coenzyme Q10 studies and effects
- Heavy Metal Exposure and Toxicity
- Antioxidants, Aging, Portulaca oleracea
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Hydrogen's biological and therapeutic effects
- Medicinal Plants and Bioactive Compounds
- Biochemical effects in animals
- Natural Antidiabetic Agents Studies
- Tryptophan and brain disorders
- Dietary Effects on Health
- Cardiovascular and exercise physiology
- Circular RNAs in diseases
Tabriz University of Medical Sciences
2016-2025
Biotechnology Research Center
2019-2020
University of Tabriz
2016
Islamic Azad University of Tabriz
2010
Baqiyatallah University of Medical Sciences
2008-2009
Objective(s): Considering the poor prognosis of ischemic heart disease and diminished effectiveness cardioprotective interventions in elderly, it becomes necessary to investigate interaction aging with protection during myocardial ischemia/reperfusion injury (IRI). This study was conducted assess impact mitoquinone (MitoQ) alpha-lipoic acid (ALA) preconditioning on cardioprotection following IRI aged rats.MethodsFifty male Wistar rats (22–24 months old) were divided into five groups...
Ischemic heart diseases are the major reasons for disability and mortality in elderly individuals. In this study, we tried to examine combined effects of nicotinamide mononucleotide (NMN) preconditioning melatonin postconditioning on cardioprotection mitochondrial function ischemia/reperfusion (I/R) injury aged male rats. Sixty Wistar rats were randomly allocated 5 groups, including sham, control, NMN-receiving, melatonin-receiving, therapy (NMN+melatonin). Isolated hearts mounted...
Multidrug resistance in tumor cells is still a big challenge cancer treatment. Therefore, identification ofsafe and effective multidrug resistance–reversing compounds with minimal side effects an important approach Here, we investigated the role potential mechanisms of peroxisome proliferator–activated receptor γ doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. The effect doxorubicin on cell viability following treatment balaglitazone, agonist, was evaluated using trypan...
Abstract Ischaemic heart diseases (IHD) are among the major causes of mortality in elderly population. Although timely reperfusion is a common treatment for IHD, it additional damage to ischaemic myocardium known as ischaemia–reperfusion (IR) injury. Considering importance preventing injuries, we aimed examine combination effect mitochondrial transplantation (MT) and coenzyme Q 10 (CoQ ) myocardial IR injury aged male rats. Seventy‐two Wistar rats were randomly divided into six groups: Sham,...
Ischemia/reperfusion (IR)-induced ventricular arrhythmia, which mainly occurs after the opening of coronary artery occlusion, poses a clinical problem. This study aims to investigate effectiveness pretreatment with coenzyme Q10 (CoQ10) in combination mitochondrial transplantation on IR-induced arrhythmias aged rats. Myocardial IR induction was performed by left anterior descending occlusion for 30 min, followed re-opening 24 hr. CoQ10 administered intraperitoneally at dosage 10 mg/kg/day two...
Abstract Myocardial ischaemia–reperfusion (IR) injury poses a severe threat to cardiac health, particularly in the ageing population, where susceptibility such damage is significantly heightened owing age‐related declines mitochondrial function, thus highlighting mitochondria as crucial targets for innovative therapies. The aim of this study was investigate combined modality therapy involving transplantation and boosters mitoquinone melatonin address myocardial IR aged rats. A total 54 male...
Background: The interaction of diabetes with cardioprotection by postconditioning in ischemia/reperfusion injury remains unclear. aim this study was to investigate the concomitant effects ischemic (IPostC) and cyclosporine-A (CsA) on nitric oxide (NO) content parameters cardiac function diabetic myocardium injured ischemia/reperfusion. Methods: Diabetes induced single injection streptozotocin (50 mg/kg; intraperitoneally [ip]) Wistar rats (250-320 g) period 8 weeks. hearts (n = 96) were...
Diabetes is associated with micro- and macro-vascular complications affecting several organs. Oxidative stress plays a crucial role in the etiology of vascular disease diabetes.The present study aimed to investigate beneficial effect troxerutin on diabetes-induced histopathological damages rat aorta focusing its antioxidative actions.Male Wistar rats were randomly divided into four groups (n = 8/each): control, control plus troxerutin, diabetic troxerutin. was induced by single...
Cardiovascular risk factors, including diabetes mellitus may attenuate the cardioprotection by postconditioning. This study aimed to investigate cardioprotective effect of ischemic-postconditioning (IPostC) against ischemia/reperfusion injury in normal and chronically type-1 diabetic rats mitochondrial permeability transition pore (mPTP) inhibition this field.Diabetes was induced a single intra-peritoneal injection streptozotocin (50 mg/kg) Wistar male (250-300 g). After 8 weeks, hearts...
Since some complications of diabetes mellitus may be caused or exacerbated by an oxidative stress, the protective effects garlic (Allium sativum) were investigated in blood and heart streptozotocin-induced diabetic rats. Twenty-eight male Wistar rats randomly divided into four groups: control, garlic, diabetic, diabetic+garlic. Diabetes was induced intraperitoneal (i.p.) injection streptozotocin (50 mg/kg) Rats fed with raw fresh homogenate (250 six days a week gavage for period 6 weeks. At...