A5045881386- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Cancer-related Molecular Pathways
- Graphene and Nanomaterials Applications
- Advanced Cellulose Research Studies
- Cancer, Hypoxia, and Metabolism
- Carbon and Quantum Dots Applications
- Electrospun Nanofibers in Biomedical Applications
- Advanced Nanomaterials in Catalysis
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatic function and diabetes
- PI3K/AKT/mTOR signaling in cancer
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Curcumin's Biomedical Applications
- Chronic Myeloid Leukemia Treatments
- Genomics, phytochemicals, and oxidative stress
- Wound Healing and Treatments
- Neuroscience and Neuropharmacology Research
- Electrochemical sensors and biosensors
- Tryptophan and brain disorders
- Nanocomposite Films for Food Packaging
Urmia University
2012-2024
Urmia University of Medical Sciences
2018-2024
University of Tabriz
2021
Tabriz University of Medical Sciences
2014-2019
Biotechnology Research Center
2017
Molecular Targeting Technologies (United States)
2017
The study was aimed at investigating the synergistic inhibitory effect of unique combinational regimen nanocapsulated Metformin (Met) and Curcumin (Cur) against T47D breast cancer cells. For this purpose, Met Cur were co-encapsulated in PEGylated PLGA nanoparticles (NPs) evaluated for their therapeutic efficacy. morphology dynamic light scattering (DLS) analyses carried out to optimize nanoformulations. Drug release performed using dialysis method then cytotoxic individual combined drugs on...
A smart, pH-responsive and biocompatible nanocarrier, aimed to achieve an efficient targeted drug delivery system, was facilely synthesized.
Resistance against chemotherapy is still a major problem in successful cancer treatment the clinic. Therefore, identifying new compounds with lower side‐effects and higher efficacy an important approach to overcome multidrug resistance (MDR). Here, we investigated activity possible mechanism of antidiabetic drug, metformin, human doxorubicin (DOX)‐resistant breast (MCF‐7/DOX) cells. The effect metformin on cytotoxicity DOX was evaluated by MTT assay. P‐gp mRNA/protein expression levels...
Multidrug resistance in tumor cells is still a big challenge cancer treatment. Therefore, identification ofsafe and effective multidrug resistance–reversing compounds with minimal side effects an important approach Here, we investigated the role potential mechanisms of peroxisome proliferator–activated receptor γ doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. The effect doxorubicin on cell viability following treatment balaglitazone, agonist, was evaluated using trypan...
Abstract Ovarian cancer is considered as one of the most lethal gynecological cancers, and cisplatin‐based therapy has an important role first‐line option for chemotherapy. Resistance to chemotherapy main obstacle against successful with cisplatin. Therefore, identifying potent compositions molecules fewer side‐effects a big challenge overcome cisplatin resistance. In this study, we investigated possible mechanism potency sanguinarine, plant‐derived alkaloid, in human cisplatin‐resistant...
This study was designed to evaluate the protective effect of silymarin (SMN) on varicocele-induced damage in testis and its effects sperm parameters antioxidant status. Wistar rats were divided into three groups: control-sham, varicocele-induced, SMN-treated varicocelized (50mg/kg, orally) rats. The count, DNA integrity, histone-protamine transition evaluated after 42 days. status analyzed by determining testicular malondialdehyde (MDA) total thiol molecules (TTM). endocrine tissue estimated...