A5039959042- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Curcumin's Biomedical Applications
- Mesenchymal stem cell research
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Essential Oils and Antimicrobial Activity
- Flavonoids in Medical Research
- Bone Tissue Engineering Materials
- Nanoparticles: synthesis and applications
- Silymarin and Mushroom Poisoning
- Synthesis and bioactivity of alkaloids
- Tissue Engineering and Regenerative Medicine
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Silk-based biomaterials and applications
- Retinoids in leukemia and cellular processes
- COVID-19 Clinical Research Studies
- Phytochemicals and Antioxidant Activities
- Advanced Nanomaterials in Catalysis
- SARS-CoV-2 and COVID-19 Research
Semnan University of Medical Sciences
2021-2025
Tabriz University of Medical Sciences
2017-2024
Biotechnology Research Center
2021-2022
University of Tabriz
2017
Shahed University
2011
Nanoparticle (NP)-based combinational chemotherapy has been proposed as a potent approach for improving intracellular drug concentrations and attaining synergistic effects in colorectal cancer therapy. Here, two well-known herbal substances, Curcumin (Cur) Chrysin (Chr), were co-encapsulated PEGylated PLGA NPs investigated their inhibitory effect against Caco-2 cells. Characterization of nanoformulated drugs was determined using DLS, FTIR, TEM, SEM. Drug release study performed dialysis...
The study was aimed at investigating the synergistic inhibitory effect of unique combinational regimen nanocapsulated Metformin (Met) and Curcumin (Cur) against T47D breast cancer cells. For this purpose, Met Cur were co-encapsulated in PEGylated PLGA nanoparticles (NPs) evaluated for their therapeutic efficacy. morphology dynamic light scattering (DLS) analyses carried out to optimize nanoformulations. Drug release performed using dialysis method then cytotoxic individual combined drugs on...
Chrysin (Chr) is a naturally occurring flavone with wide spectrum of biological functions including anti-cancer, anti-inflammatory and anti-oxidant properties. Due to the low bioavailability in vivo stability Chr at therapeutic levels for wound-healing applications, Chr-loaded PCL/PEG nanofibrous mats were successfully fabricated by optimizing electrospinning parameters characterized using FE-SEM FTIR. Results MTT showed that Human foreskin fibroblast cells (HFF-1) have more than 80%...
Silibinin (SIL) is a natural polyphenolic flavonoid with multiple biological and anti-cancer features. However, the complex hydrophobic nature inadequate bioavailability of SIL hinder its efficiency at tumor sites. Investigating possibility an extensive strategy for better treatment breast cancer, we carried out comparative exploration inhibitory effect loaded PLGA-PEG nanoparticle (SIL-NPs) on expression proapoptotic target genes, which considered as influential molecular cancer. The main...
Chemotherapeutic combinational approaches would be more efficient in decreasing toxicity of drug, preventing tumor progression relation to either drug alone. Hence, the aim this study is constract magnetic PLGA/PEG nanoparticles (NPs) co-loaded with Metformin (Met) and Silibinin (Sil) investigate their cytotoxicity as well impact on mRNA expression levels leptin receptor genes A549 lung cancer cells.The synthesized NPs were characterized by FTIR, FE-SEM, VSM then, MTT assay was utilized...
Abstract Recently, the presence of different nanoparticles (NPs) has developed targeting drug delivery in treatment cancer cell. Targeted systems using NPs have shown great promise improving efficacy intracellular uptake as well local concentration therapeutics with minimizing side effects. The current study planned to synthesized resveratrol-loaded magnetic niosomes (RSV-MNIONPs) and evaluate their cytotoxicity activity pancreatic cells. For this aim, (MNPs) were loaded into (NIOs) by thin...