Oxidative stress plays a key role in the onset and development of diabetes complications. In this study, we evaluated whether voluntary exercise could alleviate oxidative heart blood streptozotocin - induced diabetic rats.28 male Wistar rats were randomly divided into four groups (n=7): control, exercise, + diabetes. Diabetes was by injection rats. Rats trained subjected to running wheel for 6 weeks. At end six weeks tissue samples collected used determination antioxidant enzymes (including...

Insulin resistance plays a key role in the onset and development of type 2 diabetes mellitus (T2DM) its complications. In this study, we evaluated effect swim training on insulin diabetic rats.Forty male Wistar rats were randomly divided into four groups (n=10): sedentary control (Con), (Dia), trained (Exe) (Dia+Exe) rats. Diabetes was induced by high fat diet (HFD) low dose streptozotocin (35 mg/kg, i.p). groups, one week after induction diabetes, animals subjected to swimming (60 min/5...

Background: Diabetes mellitus (DM) is one of the major risk factors for cardiovascular disease, leading to endothelial dysfunction and angiogenesis impairment . MiR-126 miR-210 support angiogenic response in cells. Objective: The present study sought explore effect garlic voluntary exercise, alone or together, on miR-126 expressions cardiac rats with type 1 diabetes. Methods: Male Wistar were divided into five groups (n = 7): Control, Diabetes, Diabetes+Garlic, Diabetes+Exercise,...

Since some complications of diabetes mellitus may be caused or exacerbated by an oxidative stress, the protective effects garlic (Allium sativum) were investigated in blood and heart streptozotocin-induced diabetic rats. Twenty-eight male Wistar rats randomly divided into four groups: control, garlic, diabetic, diabetic+garlic. Diabetes was induced intraperitoneal (i.p.) injection streptozotocin (50 mg/kg) Rats fed with raw fresh homogenate (250 six days a week gavage for period 6 weeks. At...

Background & Aims:The increase in susceptibility to heart diseases old age is related with increased oxidative stress.Considering the strong antioxidant effects of prazosin, this study we investigated protective effect prazosin on stress tissue aged rats. Materials Methods:In experimental study, 18 male Wistar rats were divided into 3 groups (6 each group): 1. young (aged months), 2. 3. + prazosin.Aged animals received powder (1 mg/kg, Tocris Bioscience (Ellis ville, Mo)) diluted saline,...

Abstract Apoptosis is the main pathological aspect of neuronal injury after cerebral ischemia–reperfusion (I/R) injury. However detailed molecular mediators are still under debate. The aim this study to explore effect I/R on miR‐23a/TGF‐β‐activated kinase 1 binding protein 3 (TAB3)/nuclear factor kappa B (NF‐κB)/p53 axis in rat hippocampus alone and combination with chlorogenic acid (CGA). Common carotid artery occlusion (CCAO) was performed by nylon monofilament for 20 min establish a model...

The aim of the present study is to investigate effects caloric restriction on liver lead-administered rat. Male Sprague-Dawley rats were randomly divided into two groups: Ad libitum fed group (AL, free access normal rat chow) and (CR, 65% AL animals’ food intake). After 6 weeks, half animals each injected lead acetate other saline. Liver tissue samples collected at end experiments. Glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor (TNF- α...

<abstract> <p>Spinal cord injury (SCI) is a debilitating condition that results in impaired sensory and motor function due to the limited self-regenerative ability of spinal cord. To address this issue, combination therapy has been proposed as an effective treatment strategy for SCI regeneration. In study, Platelet-Rich Plasma (PRP)-derived exosomes loaded with dexamethasone were utilized mouse model compression. PRP-derived (Dex) prepared using ultracentrifugation sonication...

Introduction: This study aimed to evaluate the combination effect of voluntary exercise and garlic on oxidative markers, cholesterol level histological alterations in streptozotocin (STZ)- induced diabetes rat heart. Methods: Thirty-five male Wistar rats were randomly assigned into five experimental groups (n=7): Control, Diabetes, Diabetes+Garlic, Diabetes+Exercise, Diabetes+Garlic+Exercise groups. Diabetes was by STZ (ip, 50 mg/kg) animals. Animals received homogenate (250 oral gavage or...

Abstract Background Sirtuin1 is a regulator of oxidative stress involved in the management diabetes complications. Due to beneficial effects swimming training diabetes, this study aimed investigate on pancreatic Sirtuin1, and metabolic parameters type 2 diabetic male rats. Materials methods Twenty-eight Wistar rats (200–250 g) were randomly divided into four groups: control, diabetic, swim trained (n = 7). Diabetes was induced by high-fat diet streptozotocin injection [35/kg...

Introduction: The previous studies have suggested that alteration in oxidative stress and antioxidant defense depends on various factors, such as mode, intensity, frequency duration of exercise. In this study, we compared the effects two durations resistance exercise (1 month 4 month) status cardiac tissue. Methods: Thirty Wistar male rats divided into 3 groups: control (sedentary), exercise-1 (regular for 1 exercise-2 group months). After final to experiment, were anesthetized, then blood...

Regular mild exercise enhances antioxidant and anti-inflammatory systems of the body. The present study investigates voluntary effects on lead toxicity as a known oxidative stressor. Male Sprague-Dawley rats were randomly divided into 2 groups. Sedentary control: animals housed 7 weeks in regular cages. Exercise group: running wheel equipped cages, that is, animal model exercise. During 7th week, all administered acetate. Blood samples collected at end 6th week (before after...

This study aimed to evaluate the effect of tropisetron on liver injury induced by diabetes. Thirty-five male Wistar rats were assigned five groups (n = 7): control (C), (T), diabetic (D), + (D T) and glibenclamide G). Diabetic treated with (3 mg/kg body weight/day) or (1 mg/kg/day) for two weeks. Liver from exhibited a significant increase in alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP), cholesterol (Chol), triglycerides (TG), low-density lipoprotein (LDL),...