Diabetes is one of the most chronic and widespread diseases causing damages to male reproductive system. Nowadays, several studies have been performed show role phenolic compounds in reducing complications diabetes. Carvacrol a monoterpene which has shown much therapeutic efficacy various diseases.Thirty-two adult Wistar rats (n = 8 each group) were used this experimental study. The induction diabetes was using single intraperitoneal (IP) injection STZ (50 mg/kg). Rats assigned into...

Varicocoele is a swollen bulge of the pampiniform venous plexus inside scrotum. It also considered one causes infertility in males. has been demonstrated that hesperidin remarkable pharmacological potentials, including antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic effects.The present study aimed to evaluate protective effect on varicocoele-induced testicular tissue damage oxidative stress testicles adult male rats.Animals were assigned into following groups: control...

This study was designed to determine the effects of daily oral administration (250 mg/kg) hydroalcoholic extract Fumaria parviflora (FP) for 14 days on sperm parameters, oxidative stress serum testosterone levels, expression Bax and Bcl-2 genes, apoptosis index germ cells after testicular torsion–detorsion (ischaemia–reperfusion, IR) injury model in rats. Twenty-eight adult male Wistar rats were divided randomly into four groups seven each: sham operation, (TD), TD plus FP (TDFP) only...

Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias injury an vivo rat model regional ischemia. was also standardized, its evaluated. Adult male Sprague-Dawley rats subjected to 30 min ischemia by occlusion the left anterior descending coronary artery followed 5 days reperfusion. Thirty-two...

The current research aimed to assess the impacts of Minocycline on varicocele-induced regulation apoptotic-related genes and oxidative stress in testis adult Wistar rats. Thirty-two rats were divided into 4 groups: sham, varicocele (VcI), treated with (VcI + Mno) for 56 days healthy minocycline (Mno). After 8 weeks, markers levels serum investigated, afterwards, level Bax Bcl-2 expression assessed through 'immunocytochemistry' RT-qPCR assays. Also, rate apoptosis was evaluated TUNEL method....

This study aimed to determine whether syzygium aromaticum (clove) could help polycystic ovary syndrome (PCOS) rats.In this experimental study, forty adult female Wistar rats (weighing 250 ± 10 g) were divided randomly into five groups; G1: control, G2: PCOS group, G3: PCOS+clove (30 mg/kg/ orally/daily) G4: (60 mg/kg/orally/daily) and G5: PCOS+gonadectomy group. The was induced by a single dose injection of estradiol valerate (16 mg/kg/IM). Following induction, the treated for 14 days....

Objective This study used a rat model to investigate the protective effect of tadalafil and verapamil on testicular function oxidative stress after torsion/detorsion. Methods Materials Animals were randomly divided into five groups: G1, Sham group; G2, torsion followed by detorsion (TD); G3, torsion/detorsion received 0/4 mg/kg (TDT); G4, 0/1 (TDV); G5, (TDTV). All treated groups treatment 30 min before detorsion. Also, reperfusion period (24 hr), parameters spermatozoa assayed, blood was...

Objective: To evaluate the impact of Olea (O.) europaea extract on markers oxidative stress and apoptosis ovarian tissues in a rat model torsion/detorsion-induced damage.Methods: A total 28 Wistar female rats were randomly assigned into 4 groups, with 7 each group. The sham group received 2.5 cm longitudinal incision midline part abdomen which was then sutured 5-0 nylon thread; torsion/detorsion underwent torsion induction for 3 h followed by reperfusion 10 days; torsion/detorsion+O. 300...

Diabetes mellitus (DM) is a complex metabolic disease and it also closely associated with reduction in fertility male patients. The purpose of the present study was to investigate antidiabetic effect carvacrol (CRV), as potent antioxidant, on numbers germ cells Sertoli testicular tissue, messenger RNA (mRNA) protein expression some genes involved spermatogenesis, including luteinizing hormone/choriogonadotropin receptor ( LHCGR), follicle-stimulating hormone FSHR), steroidogenic factor 1...

Varicocele is one of the leading causes male infertility in which oxidative stress induces DNA damages spermatozoa patients with varicocele. Recent studies indicated that treatment antioxidant agents has protective effects against formation reactive oxygen species (ROS). Our research aimed to evaluate impact Fumaria Parviflora (FP) on varicocele-induced testicular injury. For this purpose, 32 adult Wistar rats (n = 8 per group) were randomly assigned four groups as follows: sham group,...

The current study was designed to investigate the effect of eugenol on histopathological changes and oxidative stress caused by torsion/detorsion in ovary adult female rats. In this study, forty-eight Wistar rats were classified into six groups; Sham 2 healthy group receiving 30, 60 mg/kg eugenol; ovarian torsion/detorsion; experimental groups eugenol. After ten days, plasma levels oestrogen, testosterone, some markers assessed. also, histomorphometric performed. A marked degenerative TD...

Minocycline is a widely used bacteriostatic antibiotic with various functions. The aim of this study was to investigate impact apoptotic genes in ovary the torsion/detorsion treated rat model by minocycline.This experimental performed 32 female Wistar rats classified four groups, including: i. sham, ii. TD: group received normal saline, iii. TDM: 40 mg/kg Minocycline, and iv. MC: healthy Minocycline. After treatment period (7 days), histoplogical parameters, oxidative stress markers hormone...

Background: Postoperative ileus (POI) occurs in 10% to 30% of patients following abdominal surgeries, leading prolonged hospitalization, increased complications, and elevated treatment costs. Various strategies have been proposed prevent POI its associated complications. Neostigmine, an acetylcholinesterase inhibitor, has demonstrated effectiveness treating acute colonic pseudo-obstruction (Ogilvie's syndrome). However, concerns exist regarding use surgeries that involve intestinal...

Objectives: Polycystic ovary syndrome (PCOS) has been considered as one of the most common endocrine diseases among females in their regenerative age with a prevalence range 5 to 21%.However, purpose present study was investigate protective effect Galega officinalis on metabolic well hormonal parameters rodent model PCOS.Materials and Methods: Thirty-two Wistar female rats were used (n=8/group) consisting healthy control experimental groups.The groups divided into 3 subgroups, including PCOS...

There is some evidence indicating that Matricaria chamomile (MC) had protective effects on ischemiareperfusion. In the present study, a rat model was used to investigate effect of hydroalcoholic extract MC torsion/detorsion-induced testis tissue damage.In this experimental 28 male Wistar rats were randomly divided into 4 groups as follows: G1, Sham operated; G2, testicular torsion/detorsion (T/D); G3, with received 300 mg/kg extracts 30 minutes before detorsion (T/DMC); and G4, healthy (MC)....

IntroductionOvarian torsion is one of the prevalent gynecologic emergencies, in which adnexal components swing around their axis that leads to obstruction arterial, venous, and/or lymphatic vessels (1).In this situation, gangrene and necrosis with expansion arterial insufficiency followed by primary congestion hemorrhagic infarction owing venous obstruction.However, there no data about least number turns form also for duration necessary setting (2).Diagnosis based on clinical indication...

BackgroundLipopolysaccharide (LPS) as a particle of Gram-negative bacteria is main contributer in the pathogenesis male reproductive system infectious. Male infertility due to LPS reported be related overproduction reactive oxygen species. This study aimed investigate effects olibanum on oxidative stress and apoptosis testes sperm dysfunction induced by LPS.MethodsThe (n = 28) rats were allocated four groups: control, (1 mg/kg, i.p., 14 days), + Olibanum 100 (100 200 (200 days). Germ cell...

Previous studies showed the protective effects of oxytocin (OT) on myocardial injury in ischemic and reperfused rat heart. Moreover, exposure to various stressors not only evokes sudden cardiovascular but also triggers release OT rat. The present study was aimed evaluate possible cardioprotective endogenous released response stress (St), administration exogenous ischemic–reperfused isolated heart rats previously exposed St. Wistar were divided into six groups: ischemia/reperfusion (IR); St:...

Abstract The purpose of this study was to investigate the effect clomiphene citrate and human chorionic gonadotropin (HCG) on structural changes, as well evaluation expression cation channel sperm‐associated protein 1 (CatSper1), 2 (CatSper2), luteinizing hormone/choriogonadotropin receptor (LHCGR), steroidogenic factor (SF1) genes in testicular tissue rats. All rats divided into five groups follows; G1 control group that received normal saline, G2 olive oil, G3 100 IU/kg HCG, G4 5 mg/kg...