A5034111307- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Ovarian function and disorders
- Vitamin D Research Studies
- Systemic Lupus Erythematosus Research
- Cannabis and Cannabinoid Research
- Thyroid Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Stress Responses and Cortisol
- Folate and B Vitamins Research
- Immune Cell Function and Interaction
- Occupational and environmental lung diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Trace Elements in Health
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Hemoglobinopathies and Related Disorders
- Chemotherapy-induced organ toxicity mitigation
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Chronic Myeloid Leukemia Treatments
- T-cell and B-cell Immunology
- Genetic and Kidney Cyst Diseases
Urmia University of Medical Sciences
2015-2024
Urmia University
2015-2024
Baqiyatallah University of Medical Sciences
2022-2023
Islamic Azad University, Tehran
2021
Islamic Azad University Medical Branch of Tehran
2021
Cellular Research (United States)
2017
Tehran University of Medical Sciences
2005
Khatam University
2004
Chronic myelogenous leukaemia (CML) is a disorder of the haematopoietic stem cell that results in malignant expansion myeloid cells with cytogenetic abnormality, and translocation between chromosomes 9 22, known as Philadelphia chromosome. It has been hypothesized genetic factors other than histocompatibility disparity may play role predisposition to developing CML. In this regard, T helper types 1 2 (Th1 Th2) cytokines their gene polymorphism seem be important. Overall expression secretion...
In this study, it was determined whether the IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 polymorphisms were associated with suicidal behavior. One hundred forty five patients behavior 160 normal individuals genotyped for using ASO-PCR method. G/G genotype has been increased in males completed suicide versus control group (p value = 0.017). -1082 A/A is higher both male female groups (+874) significantly 0.027). It can be concluded that IL-10, IFN-gamma, may play a role
This study examined the effect of melatonin on oxidative stress, expression pro-apoptotic protein, anti-apoptotic proteins, and activity PI3K/Akt signaling pathway in human ovarian cancer cell line (OVCAR3). OVCAR3 cells were treated with cisplatin, melatonin, cisplatin + siRNA Akt. Reactive oxygen species levels assessed. The proteins was determined by Western blot. Melatonin administration significantly increased intracellular ROS generation, cleavage caspase 3 decreased phosphorylation...
Background: Some genetic factors are involved in the etiology of Hashimoto thyroiditis and Graves' disease as autoimmune thyroid diseases (AITDs). Effects vitamin D receptor gene polymorphisms AITDs development have already been investigated some previous studies. However, no study has done on association between VDR FokI ApaI an Iranian population. In this study, possible effects were population northwest Iran. Methods: A total 121 adult patients 117 healthy controls matched by age sex same...
Several factors which influence the balance between fibrinolysis and coagulation pathways play role in outcome of conception. A large body studies demonstrate that gene variations are associated with recurrent pregnancy loss (RPL) by different mechanisms. We aimed to determine allele genotype frequencies angiotensin converting enzyme (ACE) Iranian Azeri Turkish women unexplained RPL. Fifty patients RPL 63 fertile healthy as controls were entered study. standard method was used for DNA...
The GABAergic synapses go through structural and functional maturation during early brain development. Maternal stress alters in developing brain, which are associated with the pathophysiology of neuropsychiatric disorders adults. present study aimed to investigate effect prenatal restraint (PS) on pilocarpine-induced seizure ɑ5 subunit γ-amino butyric acid type A (GABAA) receptor expression hippocampus. Pregnant Wistar rats were subjected PS at gestational days 15-17 pups examined for...
Abstract Many risk factors have been identified for suicide behavior and although a role cytokines has suggested in specific psychiatric conditions behavior, this is not well‐defined. Since some polymorphisms can alter the expression of cytokines, study we attempted to assess TGF‐β1 codon 10 (T/C) (rs1982073) behavior. A total 145 individuals with as well 200 control participants (without any history behavior) were included study. polymorphism was determined using allele‐specific...
STUDY OF RS4253778 POLYMORPHISM RELATED TO PEROXISOME PROLIFERATOR ALPHA RECEPTOR GENE IN RAPAMYCIN-TREATED KIDNEY TRANSPLANT RECIPIENTS WEST AZARBAIJAN PROVINCE (IRAN)
summary . Cytokine gene polymorphisms may affect their transcription, influence level of production and be implicated in inducing susceptibility or resistance to diseases. In 40 Iranian healthy subjects, cytokine single‐nucleotide (SNPs) were used determine allelic genotypic frequencies for the following genes: IL‐1a (T/C −889), IL‐1β (C/T −511, T/C 3962), IL‐12 (C/A −1188), IFN‐γ (A/T UTR 5644), TGF‐β codon 10, G/C 25), TNF‐a (G/A −308, G/A −238), IL‐2 (T/G −330, G/T 166), IL‐4 −1089, −590,...
The present study was carried out to assess the frequencies of factor XIII (FXIII) Val34Leu genetic variation in patients with recurrent spontaneous abortion and healthy fertile women Azeri Turkish origin. A total 54 46 as controls were studied for FXIII by a RFLP-PCR method. Statistical analysis showed that (χ2 = 2.4, p value 0.292) 1.035, 0.596) agreement Hardy-Weinberg equilibrium. Leu allele frequency 0.18 0.13 controls, respectively. Leu34Leu (homozygous 34Leu) genotype not found...
The association between single nucleotide polymorphisms (SNPs) in the interleukin (IL)-17 gene and silicosis has been evaluated different populations. aim of present study was to analyze SNPs at IL-17A (−832A/G) IL-17F (+7488A/G) susceptibility accelerated Iranian Kurdish population. We studied 48 patients with 62 controls. Genomic DNA isolated using “salting out” method. PCR-RFLP performed for all typing. frequencies A/A, A/G, G/G genotypes were 4 (8.33%), 23 (47.92%), 21 (43.75%) 5...
The study was conducted to evaluate the association between MMP-1 (rs1799750)-1607 1G/2G and MMP-3 (rs3025058)-1612 5A/6A polymorphisms/haplotypes coronary artery disease (CAD) risk among Iranian Turks. Totally, 102 patients with CAD healthy subjects joined study. Genomic DNA isolation carried out using "salting out" method from 3 4 mL of whole blood samples. (-1607 2G/1G) (-1612 5A/6A) promoter gene polymorphisms were detected via polymerase chain reaction restriction fragment length...