A5010475657- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Computational Drug Discovery Methods
- Parasites and Host Interactions
- Drug-Induced Hepatotoxicity and Protection
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- COVID-19 epidemiological studies
- Hemoglobinopathies and Related Disorders
- HIV/AIDS Impact and Responses
- Insect Pest Control Strategies
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Immune responses and vaccinations
- Evolution and Genetic Dynamics
- Plant Virus Research Studies
- COVID-19 and Mental Health
- Viral Infections and Outbreaks Research
- Trypanosoma species research and implications
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
Instituto Nacional de Saúde
2005-2024
Ministry of Health
2014-2024
Malaria Consortium
2022
Manhiça Health Research Centre
2004-2017
Ministério da Saúde
2012-2017
Universitat de Barcelona
2017
Institut Pasteur du Cambodge
2017
Institut Pasteur
2017
World Health Organization - Pakistan
2017
Barcelona Institute for Global Health
2017
We assessed adherence to government recommendations implemented shortly after the introduction of COVID-19 in Mozambique March 2020, through two online cross-sectional surveys April and June 2020. quantified preventive measures by a composite score comprising five measures: physical distancing, face mask use, hand hygiene, cough avoidance touching face. 3770 1115 persons participated first second round respectively. Wearing masks, regular handwashing hygiene all reached compliance rates over...
Using serum or infected blood from Danish volunteers and Plasmodium falciparum-infected Mozambican patients, respectively, the impact of curative doses chloroquine pyrimethamine/sulfadoxine upon infectivity P. falciparum to Anopheles arabiensis An. gambiae berghei stephensi was studied. Both treatments cleared circulating gametocytes within 28 days. Before this clearance, enhanced arabiensis, whereas decreased infectivity. Patients harboring chloroquine-resistant parasites as opposed...
A temporal and spatial study of malaria transmission in a suburban area Maputo, Mozambique with mean population density 2,737/km2 was made from December 1992 to June 1995. steep but continuous gradient observed the Plasmodium falciparum prevalence 59.0% adjacent breeding sites 5.4% only few hundred meters distant. The entomologic inoculation rate ranged number too low be determined some districts 20 infectious bites per person year others. risk 6.2 times higher for individuals living less...
Abstract One of the fundamental steps toward malaria control is use antimalarial drugs. The success treatment can be affected by presence drug-resistant populations Plasmodium falciparum. To assess resistance, we used molecular methods to examine 351 P. falciparum isolates collected from 4 sentinel sites in Mozambique for K13, pfmdr1, pfcrt, and pfdhps polymorphisms plasmepsin2 (pfpm2) pfmdr1 copy numbers. We found multiple copies pfpm2 1.1% isolates. All carried K13 wild-type alleles...
Abstract Mozambique is one of the four African countries which account for over half all malaria deaths worldwide, yet little known about parasite genetic structure in that country. We performed P. falciparum amplicon and whole genome sequencing on 2251 malaria-infected blood samples collected 2015 2018 seven provinces to genotype antimalarial resistance markers interrogate population using genome-wide microhaplotyes. Here we show only resistance-associated observed at frequencies above 5%...
Summary This paper reports a two‐phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine–pyrimethamine (SP) amodiaquine (AQ), then tested safety treatment uncomplicated malaria, three combinations: AQ + SP, artesunate (AR) SP AR. Based on WHO (1996, WHO/MAL/96.1077) vivo protocol, conducted two open, randomized, trials. Children aged 6–59 months with axillary body temperature...
The candidate malaria vaccine RTS,S/AS02A is a recombinant protein containing part of the circumsporozoite (CSP) sequence Plasmodium falciparum, linked to hepatitis B surface antigen and formulated in proprietary adjuvant system AS02A. In recent trial conducted children younger than age five southern Mozambique, demonstrated significant sustained efficacy against both infection clinical disease. follow-up study main trial, breakthrough infections identified were examined determine whether...
Abstract Background Seasonal malaria chemoprevention (SMC) is a highly effective intervention for prevention in high burden areas with seasonal transmission, historically implemented the Sahel. Mozambique contributes to 4% of global cases. Malaria Consortium, partnership National Control Programme, conducted two-year phased SMC study Nampula province using sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), or SPAQ, children under five. Phase one results presented here highlight...
Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum dihydrofolate reductase (dhfr), and dihydropteroate synthetase (dhps), chloroquine resistance transporter (Pfcrt) genes are used as molecular markers of P. to sulfadoxine/pyrimethamine chloroquine. However, be a practical tool surveillance drug resistance, simpler methods for high-throughput haplotyping warranted. Here we describe quick simple technique that detects dhfr, dhps, Pfcrt SNPs using polymerase chain reaction...
Background Malaria remains a significant health problem in Mozambique, particularly the case of pregnant women and children less than five years old. Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPT-SP) is recommended for preventing malaria pregnancy (MiP). Despite widespread use cost-effectiveness IPTp-SP, coverage low. In this study, we explored factors limiting access to IPTp-SP rural part Mozambique. Methods findings We performed qualitative study using...
Background Reliable HIV incidence estimates for Mozambique are limited. We conducted a prospective study as part of clinical research site development initiative in Chókwè district, Gaza Province, southern Mozambique. Methods Between June 2010 and October 2012, we recruited women at sites where higher risk infection would likely be found. enrolled tested 1,429 sexually active the screening phase 479 uninfected phase. Participants were scheduled 12+ months follow-up, when they underwent...
Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in year 2006, and since 2009 artemether-lumefantrine (AL) artesunate-amodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentre study was conducted five sites across country to assess vivo efficacy tolerability these two drugs. Children aged six 59 months with were recruited between June 2011 January 2012 (Montepuez, Dondo, Tete,...
Malaria in pregnancy leads to serious adverse effects on the mother and child accounts for 75,000-200,000 infant deaths every year. Currently, World Health Organization recommends intermittent preventive treatment of malaria (IPTp) with sulfadoxine-pyrimethamine (SP) at each scheduled antenatal care (ANC) visit. This study aimed assess IPTp-SP coverage mothers delivering health facilities community. In addition, factors associated low uptake outcomes were investigated.A community a...
Introduction Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims operationalise functional malaria molecular system Mozambique for guiding control and elimination. Methods analyses prospective seeks generate Plasmodium falciparum genetic (1) monitor markers drug resistance deletions rapid diagnostic test targets; (2) characterise...
BackgroundFrom the start of SARS-CoV-2 outbreak, global sequencing efforts have generated an unprecedented amount genomic data. Nonetheless, unequal sampling between high-income and low-income countries hinders implementation surveillance systems at local level. Filling knowledge gaps information understanding pandemic dynamics in is essential for public health decision making to prepare future pandemics. In this context, we aimed discover timing origin variant introductions Mozambique,...
Plasmodium falciparum resistance to sulfadoxine/pyrimethamine (S/P) is due mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase genes. Large-scale screening of prevalence these could facilitate surveillance level S/P vivo. The dhfr dhps relation efficacy was studied four sites differing endemicity Sudan, Mozambique, Tanzania. were organized order increasing a significant increase triple codons c51, c59, c108 observed. A similar trend observed when genotypes combined...
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. 2004, this has been altered to SP/artesunate in line with WHO recommendations using Artemisinin Combination Therapies (ACTs), despite fact that all neighbouring countries have abandoned SP-drug combinations due high levels SP drug resistance. study area, one year prior change SP/AQ, alone was used treat malaria...
Acute diarrhea disease caused by Rotaviruses A (RVA) is still the leading cause of morbidity and mortality in children ≤5 years old developing countries. An exploratory cross‐sectional study was conducted between February September, 2011 to determine proportion acute RVA. total 254 stool specimens were collected from with diarrhea, including outpatients (222 children) inpatients (32 children), three local health centers Chókwè District, Gaza Province, South Mozambique. RVA antigens detected...
Seasonal malaria chemoprevention (SMC) is a highly effective community-based intervention to prevent infections in areas where the burden high and transmission occurs mainly during rainy season. In Africa, so far, SMC has been implemented Sahel region. Mozambique contributes 4% of global cases, responsible for one-quarter all deaths country. Based on recommendations Malaria Strategic Plan, Consortium, partnership with National Control Programme Mozambique, initiated phased implementation...
Journal Article The mosquito transmission of malaria: the effects atovaquone-proguanil (Malarone™) and chloroquine Get access S. Enosse, Enosse 1Department Blood Parasitology, National Institute Health, Maputo, Mozambique Search for other works by this author on: Oxford Academic PubMed Google Scholar G.A. Butcher, Butcher ∗ 2Department Biology, Imperial College Science, Technology Medicine, London SW7 2AZ, UK ∗Address correspondence: G. A. Biology Department, BMS Building, Road, UK; phone...
Background Malaria is a significant cause of morbidity and mortality in children aged under 5 years Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration four monthly courses sulfadoxine-pyrimethamine (SP) amodiaquine (AQ), to 3-59 months during rainy season. However, as resistance SP widespread East Southern Africa, SMC has so far only been implemented across Sahel West Africa. Objective This protocol describes first phase pilot...