A5022219556- Malaria Research and Control
- Mosquito-borne diseases and control
- Computational Drug Discovery Methods
- HIV/AIDS drug development and treatment
- Global Maternal and Child Health
- Insect Pest Control Strategies
- Research on Leishmaniasis Studies
- HIV/AIDS Impact and Responses
- Parasites and Host Interactions
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
Instituto Nacional de Saúde
2017-2024
Ministry of Health
2017-2021
National Institutes of Health
2021
Ministério da Saúde
2017
Universitat de Barcelona
2017
Institut Pasteur du Cambodge
2017
Institut Pasteur
2017
World Health Organization - Pakistan
2017
Barcelona Institute for Global Health
2017
World Health Organization
2017
Abstract One of the fundamental steps toward malaria control is use antimalarial drugs. The success treatment can be affected by presence drug-resistant populations Plasmodium falciparum. To assess resistance, we used molecular methods to examine 351 P. falciparum isolates collected from 4 sentinel sites in Mozambique for K13, pfmdr1, pfcrt, and pfdhps polymorphisms plasmepsin2 (pfpm2) pfmdr1 copy numbers. We found multiple copies pfpm2 1.1% isolates. All carried K13 wild-type alleles...
While the
Malaria in pregnancy leads to serious adverse effects on the mother and child accounts for 75,000-200,000 infant deaths every year. Currently, World Health Organization recommends intermittent preventive treatment of malaria (IPTp) with sulfadoxine-pyrimethamine (SP) at each scheduled antenatal care (ANC) visit. This study aimed assess IPTp-SP coverage mothers delivering health facilities community. In addition, factors associated low uptake outcomes were investigated.A community a...
Vector control tools have contributed significantly to a reduction in malaria burden since 2000, primarily through insecticidal-treated bed nets (ITNs) and indoor residual spraying. In the face of increasing insecticide resistance key vector species, global progress has stalled. Innovative tools, such as dual active ingredient (dual-AI) ITNs that are effective at killing insecticide-resistant mosquitoes recently been introduced. However, large-scale uptake slow for several reasons, including...
Malaria remains one of the most serious public health problems in sub-Saharan Africa and Mozambique is world's fourth largest contributor, with 4.7% disease cases 3.6% total deaths due to malaria. Its control relies on fight against vector treatment confirmed anti-malarial drugs. Molecular surveillance an important tool for monitoring spread drug resistance.A cross-sectional study recruited 450 participants malaria infection detected by Rapid Diagnostic Tests, from three different sites...
Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as first choice. To assess efficacy of currently used ACT, an vivo therapeutic study was conducted.The conducted four sentinel sites: Montepuez, Moatize, Mopeia Massinga. Patients between 6 59 months old Plasmodium falciparum (2000-200,000 parasites/µl) were enrolled February...
Due to the threat of emerging anti-malarial resistance, World Health Organization recommends incorporating surveillance for molecular markers resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) was conducted in Mozambique, prevalence polymorphisms pfk13, pfcrt, pfmdr1 genes associated with drug investigated. Children aged 6-59 months were enrolled four study sites. Blood collected dried on filter paper...
Abstract Background : Artemisinin-based combination therapy has been the recommended treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as first-line treatments. To assess efficacy of currently used artemisinin-based therapy, an vivo therapeutic study was conducted. Methods The conducted four sentinel sites: Montepuez, Moatize, Mopeia Massinga. Patients between 6 to 59 months old Plasmodium falciparum...
Abstract Background: Malaria is still a leading cause of morbidity and mortality among children under five years old in Mozambique. In this study we sought to determine the prevalence malaria infection its predictors six 59 months Methods: Data from two national indicators surveys 2015 2018 were compared. both surveys, blood samples collected detect Plasmodium falciparum antigen by rapid diagnostic test, questionnaires applied collect socio-economic, demographic vector control data their...
Abstract Malaria remains one of the most serious public health problem in sub-Saharan Africa and Mozambique is world's fourth largest contributor, with 4.7% disease cases 3.6% total deaths due to malaria. Its control relies on fight against vector treatment confirmed antimalarial drugs. Molecular surveillance important tool for monitoring spread drug resistance. A cross-sectional study recruited 450 participants malaria infection detected by Rapid Diagnostic Test, from three different sites...