A5020626682- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect Pest Control Strategies
- Insect Resistance and Genetics
- Entomopathogenic Microorganisms in Pest Control
- Viral Infections and Vectors
- Iron Metabolism and Disorders
- Vector-borne infectious diseases
- Medical Imaging Techniques and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Insect and Pesticide Research
- Environmental Toxicology and Ecotoxicology
- Travel-related health issues
- Genetic diversity and population structure
- Radiomics and Machine Learning in Medical Imaging
- Parasites and Host Interactions
- Macrophage Migration Inhibitory Factor
- Quality and Safety in Healthcare
- Biomedical and Engineering Education
- Genetic Mapping and Diversity in Plants and Animals
- Insect Utilization and Effects
- Pesticide Exposure and Toxicity
- Nuclear Receptors and Signaling
- Biotechnology and Related Fields
- Global Maternal and Child Health
Innovative Vector Control Consortium
2021-2025
Liverpool School of Tropical Medicine
2022-2023
Centre National de Recherche et de Formation sur le Paludisme
2023
Global Fund to Fight AIDS, Tuberculosis and Malaria
2023
U.S. President's Malaria Initiative
2015-2021
United States Agency for International Development
2015-2020
National Office for Sanitation of Senegal
2020
London School of Hygiene & Tropical Medicine
2020
Université des Sciences, des Techniques et des Technologies de Bamako
2020
Abt Associates (Nepal)
2020
Movement of individuals promotes colonization new areas, gene flow among local populations, and has implications for the spread infectious agents control pest species. Wild Norway rats (Rattus norvegicus) are common in highly urbanized areas but surprisingly little is known their population structure. We sampled from 11 locations within Baltimore, Maryland, to characterize genetic structure extent between city. Clustering methods a neighbour-joining tree based on pairwise distances supported...
Anopheles arabiensis mosquitoes are the primary vector responsible for Plasmodium falciparum transmission in Macha, Zambia. Because insecticide-treated bed nets (ITNs) have potential to alter host feeding behavior, extent of zoophilic and exophagic tendencies was evaluated during two rainy seasons after ITN introduction. Centers Disease Control light traps, paired indoor/outdoor human landing catches, outdoor cattle-baited collections were used assess changes preference. Results support...
The impact of indoor residual spraying (IRS) and long-lasting insecticide nets (LLINs), key components the national malaria control strategy Mali, is threatened by vector resistance. objective this study was to assess level resistance in Anopheles gambiae sensu lato populations from Mali against four classes recommended for IRS: organochlorines (OCs), pyrethroids (PYs), carbamates (CAs) organophosphates (OPs). Characterization done 13 sites across southern assessed presence distribution...
Abstract Indoor residual spraying (IRS) of insecticides is a major vector control strategy for malaria prevention. We evaluated the impact single round IRS with organophosphate, pirimiphos-methyl (Actellic 300CS), on entomological and parasitological parameters in Migori County, western Kenya 2017, an area where primary vectors are resistant to pyrethroids but susceptible compound. Entomological monitoring was conducted by indoor CDC light trap, pyrethrum spray catches (PSC) human landing...
In 2017, more than 5 million house structures were sprayed through the U.S. President's Malaria Initiative, protecting 21 people in sub-Saharan Africa. New IRS formulations, SumiShield™ 50WG and Fludora Fusion™ WP-SB, became World Health Organization (WHO) prequalified vector control products 2017 2018, respectively. Both formulations contain neonicotinoid active ingredient, clothianidin. The target site of neonicotinoids represents a novel mode action for control, meaning that...
Indoor residual spraying (IRS) is the application of insecticide to interior walls household structures that often serve as resting sites for mosquito vectors malaria. Human exposure malaria reduced when IRS involves proper pre-determined concentrations active ingredient specific formulation choice. The impact can be affected by dosage insecticide, spray coverage, vector behavior, susceptibility insecticides, and efficacy applied. This report compiles data on insecticides used in campaigns...
Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) remain the cornerstones of malaria vector control. However, development insecticide resistance its implications for operational failure preventative strategies are concern. The aim this study was to characterize among Anopheles arabiensis populations in Ethiopia describe temporal spatial patterns between 2012 2016. Between 2016, status An. assessed annually during long rainy seasons sites from seven nine regions...
Anopheles coustani s.l. and squamosus are sub-Saharan mosquito species that have been implicated in malaria transmission. Although generally believed to be of negligible importance due their overwhelmingly zoophilic behavior, An. made up a large proportion the anophelines collected by human landing catches during 2007-2008 2008-2009 rainy seasons Macha, Zambia. Further, polymerase chain reaction-based blood meal identification showed majority meals from these caught human-baited Centers for...
Human landing catches (HLCs) are currently the preferred method to determine vector human biting rates (HBRs), which key determinants of entomologic inoculation and important measures for assessing impact control efforts. Although HLCs most direct means establishing HBRs, they labor-intensive, their use is facing increasing ethical concerns. The relationship between Centers Disease Control (CDC) light traps HLC collections was evaluated in Macha, Zambia during 2007–2008 2008–2009 rainy...
The Gulf Coast tick, Amblyomma maculatum, is a vector of Rickettsia parkeri, recently identified human pathogen that causes disease with clinical symptoms resemble mild form Rocky Mountain spotted fever. Because the prevalence R. parkeri infection in geographically distinct populations A. maculatum not fully understood, specimens collected as part tick and surveillance system Fairfax County, Virginia, were screened to determine rates. Overall, was found 41.4% screened. Additionally, novel...
Abstract Background Ghana has been implementing the indoor residual spraying (IRS) of insecticides since 2006, focusing operations in north. Insecticide resistance concerns prompted a switch from pyrethroids to organophosphates, beginning gradually 2011 and switching fully micro-encapsulated formulation pirimiphosmethyl (PM CS), Actellic ® 300CS, third-generation (3GIRS) product, by 2014. Entomological surveillance studies have shown IRS be highly effective malaria control tool, but...
Background: Insecticide Treated Nets (ITNs) vary greatly in their physical characteristics yet the relationship with field durability remains poorly understood. To address this, we refined existing resistance to damage (RD) metric for greater predictive power estimating operational lifespan and identify key avenues of innovation. Methods: The original (oRD) score was calculated by comparing four attributes; snag strength, bursting hole enlargement abrasion resistance; against aspirational...
Indoor residual spraying (IRS) is being implemented as one of the malaria prevention methods in Northern Region Ghana. Changes longevity, sporozoite and entomological inoculation rates (EIRs) major vectors were monitored to assess impact IRS selected districts. Monthly human landing catches (HLCs) used collect mosquitoes from sentinel sites three adjacent districts between July 2009 December 2014: Savelugu Nanton (SND) where had been 2008 2014; Tolon Kumbungu (TKD) 2012 Tamale Metropolis...
Globally, the Democratic Republic of Congo (DRC) accounted for 9% malaria cases and 10% deaths in 2015. As part control efforts, more than 40 million long-lasting insecticidal nets (LLINs) were distributed between 2008 2013, resulting 70% households owning one or LLINs 2014. To optimize vector it is critical to monitor behaviour insecticide resistance trends. Entomological data was collected from eight sentinel sites throughout DRC 2013 2016 Kingasani, Mikalayi, Lodja, Kabondo, Katana,...
The impact of insecticide resistance in malaria vectors is poorly understood and quantified. Here a series geospatial datasets for are provided, so that trends time space can be quantified, the found wild populations on transmission Africa assessed. Specifically, data have been collated geopositioned prevalence resistance, as measured by standard bioassays, representative samples individual species or complexes. Data provided Anopheles gambiae complex, funestus subgroup, nine vector species....
Abstract Background Attaining the goal of reducing global malaria burden is threatened by recent setbacks in maintaining effectiveness vector control interventions partly due to emergence pyrethroid resistant vectors. One potential strategy address these could be combining indoor residual spraying (IRS) with non-pyrethroids and standard insecticide-treated nets (ITNs). This study aimed provide evidence on incremental epidemiological benefit using third-generation IRS product a highly endemic...
Durability monitoring of insecticide-treated nets (ITNs) containing a pyrethroid in combination with second active ingredient (AI) must be adapted so that the insecticidal bioefficacy each AI can monitored independently. An effective way to do this is measure rapid knock down pyrethroid-susceptible strain mosquitoes assess component and use pyrethroid-resistant ingredient. To allow robust comparison results across tests within between test facilities, over time, protocols for testing include...
Anopheles arabiensis is a major vector of Plasmodium falciparum in southern Zambia. This study aimed to determine the rate multiple human blood meals taken by An. more accurately estimate entomologic inoculation rates (EIRs). Mosquitoes were collected four village areas over two seasons. DNA from was extracted and amplified at microsatellite loci. Using three-allele method, which counts ≥ 3 alleles any locus as meal, we determined that overall frequency 18.9%, higher than reported for...
Millions of pyrethroid LLINs have been distributed in Mali during the past 20 years which, along with agricultural use, has increased selection pressure on malaria vector populations. This study investigated resistance intensity and susceptible status vectors to alternative insecticides guide choice for IRS effective control vectors.