A5000076915- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Insects and Parasite Interactions
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Insect symbiosis and bacterial influences
- Insect Pest Control Strategies
- Trypanosoma species research and implications
- Helminth infection and control
- Mycobacterium research and diagnosis
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Insect Resistance and Genetics
- Infectious Diseases and Mycology
- Food Allergy and Anaphylaxis Research
- Child Nutrition and Water Access
- Monoclonal and Polyclonal Antibodies Research
- Zoonotic diseases and public health
- Viral Infections and Vectors
- Bioactive Compounds and Antitumor Agents
- Morinda citrifolia extract uses
- Nematode management and characterization studies
- Dengue and Mosquito Control Research
Noguchi Memorial Institute for Medical Research
2015-2024
University of Ghana
2015-2024
Kwame Nkrumah University of Science and Technology
2020-2024
Amway (United States)
2024
Ministry of Public Health
2022
Weatherford College
2022
University of Science and Technology
2020
Kwame Nkrumah University
2020
University of Cape Coast
2020
Leibniz Institute for Psychology
2020
Background Ivermectin (IVM) has been used in Ghana for over two decades onchocerciasis control. In recent years there have reports of persistent microfilaridermias despite multiple treatments. This necessitated a reexamination its microfilaricidal and suppressive effects on reproduction the adult female Onchocerca volvulus. an initial study, we demonstrated continued potent effect IVM. However, also found communities which skin microfilarial repopulation rates at days 90 180 were much higher...
Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa Central/South America. Mass drug is likely to exert selection pressure on parasites, phenotypic genetic changes in several Onchocerca volvulus populations from Cameroon Ghana-exposed more than a decade regular treatment-have raised concern that sub-optimal responses ivermectin's anti-fecundity effect are becoming frequent may spread.Pooled next generation sequencing...
Background Community Directed Treatment with ivermectin is the cornerstone of current efforts to eliminate onchocerciasis. However recent studies suggest there are foci where long-term annual distribution drug alone has failed ensure elimination thresholds reached. It important achieve high levels compliance in order obtain targets. An epidemiological and entomological evaluation conducted western region Cameroon 2011 revealed that two health districts remained a prevalence infection,...
Background. Several African countries have adopted a biannual ivermectin distribution strategy in some foci to control and eliminate onchocerciasis. In 2010, the Ghana Health Service started combat transmission hotspots suboptimal responses treatment. We assessed epidemiological impact of first 3 years this quantified over 2 consecutive rounds treatment 10 sentinel communities. Methods. evaluated Onchocerca volvulus community microfilarial intensity prevalence persons aged ≥20 before first,...
If ivermectin-based programmes for the control of human onchocerciasis are to be successful, drug must remain effective as long necessary. In an open, case-control study, attempt was made determine if persistent, significant, Onchocerca volvulus microfilaridermias seen in some individuals who had received at least nine treatments with ivermectin were result development resistance parasite. Twenty-one these 'sub-optimal' responders (cases) matched, by age, weight, number treatments, locality...
In the detection of parasitic infection, traditional methods based on microscopy often have low sensitivity and/or specificity compared with newer, molecular tests. An assay real-time PCR and a reagent strip test for detecting circulating cathodic antigen (CCA) both now been urine filtration microscopy, in Schistosoma haematobium infections. Urine samples, obtained from 74 'cases' areas Ghana endemic S. 79 'controls' non-endemic areas, were each checked using three methods. With results...
Due to the socioeconomic impact of human onchocerciasis (commonly referred as river blindness) in West Africa, Onchocerciasis Control Programme Volta River Basin (OCP) was instituted [1]. This initial programme started 1975 and covered seven African countries: Benin, Burkina Faso, Cote d’Ivoire, Ghana, Mali, Niger, Togo. However, later evidence indicated that endemic areas outside area posed a threat achievement OCP and, hence, extended southward westward include four additional countries,...
Abstract Background School children have been increasingly recognized as health messengers for malaria control. However, little evidence is available. The objective of this study was to determine the impact school-based education intervention on school and community adults. Methods This conducted in Dangme-East district Greater Accra Region, Ghana, between 2007 2008. Trained schoolteachers designed participatory activities led disseminate messages related control their communities. Three...
Background Massangam health district (HD), in the West Region of Cameroon, has received ivermectin mass drug administration (MDA) for 20 years, however there is evidence continued high transmission Onchocerca volvulus. In order to better understand dynamics HD and inform intervention strategies a need delineate boundaries suspected area within wider zone. Methodology/Principal findings Parasitological entomological surveys were conducted map out breeding sites Simulium damnosum evaluate...
Mycobacterium ulcerans, the causative agent of Buruli ulcer, is an emerging environmental bacterium in Australia and West Africa. The primary risk factor associated with ulcer proximity to slow moving water. Environmental constraints for disease are shown by absence infection arid regions infected countries. A particularly mysterious aspect fact that endemic non-endemic villages may be only a few kilometers apart within same watershed. Recent studies suggest aquatic invertebrate species...
Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when prevalence levels decreased a that MDA can be discontinued without threat recrudescence. six-country study was conducted assessing performance seven tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community...
Summary We developed a DNA assay for bloodmeal identification in haematophagous insects. Specific host cytochrome B gene sequences were amplified by PCR and classified on the basis of their mobility heteroduplex assay. In blackfly Simulium damnosum s.l. (Diptera: Simuliidae), human identifiable up to 3 days following ingestion bloodmeal. tsetse Glossina palpalis Glossinidae) collected from traps Ivory Coast, bloodmeals identified as taken domestic pigs pattern sequence. Evidently sequence...
The Global Program to Eliminate Lymphatic Filariasis has been implemented reduce human microfilaremia levels low enough break the transmission of disease by using single annual doses albendazole in combination with diethylcarbamazine or ivermectin. Many veterinary helminth parasites have developed resistance against both and Resistance nematodes is known be caused either two amino acid substitutions from phenylalanine tyrosine parasite beta-tubulin at position 167 200. We assays capable...
AbstractThe pathogenesis of the sub-optimal response Onchocerca volvulus to ivermectin was investigated in a 30-month follow-up 28 individuals who, previous study, had been found show (N = 15) or adequate 13) multiple treatments with drug. Verbal informed consent obtained before each subject given general clinical and ocular examination. Skin snips were taken from both iliac crests calves. Seventeen nodule carriers hospitalized for nodulectomy. Adult worms harvested, embryogrammes...
To cite this article: Bousquet J, Schünemann HJ, Zuberbier T, Bachert C, Baena‐Cagnani CE, PJ, Brozek Canonica GW, Casale TB, Demoly P, Gerth van Wijk R, Ohta K, Bateman ED, Calderon M, Cruz AA, Dolen WK, Haughney Lockey RF, Lötvall O’Byrne Spranger O, Togias A, Bonini S, Boulet LP, Camargos Carlsen KH, Chavannes NH, Delgado L, Durham SR, Fokkens WJ, Fonseca Haahtela Kalayci Kowalski ML, Larenas‐Linnemann D, Li Mohammad Y, Mullol Naclerio O’Hehir RE, Papadopoulos N, Passalacqua G, Rabe KF,...
Anopheles gambiae s.s mosquitoes are important vectors of lymphatic filariasis (LF) and malaria in Ghana. To better understand their ecological aspects influence on disease transmission, we examined the spatial distribution An. (M S) molecular forms associated environmental factors, determined relationship with prevalence. Published current data available species Ghana were collected a database for analysis, study sites georeferenced mapped. Using sites, derived from climate, vegetation...
BackgroundThe prevalence of peanut allergy has increased in developed countries, but little is known about developing countries with high consumption and widespread parasitic infections.ObjectiveWe sought to investigate Ghana.MethodsIn a cross-sectional survey among Ghanaian schoolchildren (n = 1604), data were collected on reported adverse reactions peanut, sensitization (serum specific IgE skin reactivity), patterns, infections. In subset 43) against Ara h 1, 2, 3, 9 as well cross-reactive...
Abstract Background Recent data from Ghana indicates that after seven rounds of annual mass drug administration (MDA) there is still sustained transmission albeit at low levels in certain areas where Anopheles melas , An. gambiae s.s., Mansonia and Culex species are the main biting mosquitoes. s.l. funestus known vectors a recent report indicated could transmit level microfilaraemia. However, because not found everywhere was need to determine whether any other culicine also be playing role...
Abstract Immunoglobulin G (IgG) Fc N-glycosylation affects antibody-mediated effector functions and varies with inflammation rooted in both communicable non-communicable diseases. Worldwide, diseases tend to segregate geographically. Therefore, we studied whether IgG populations different environmental exposures parts of the world. was analysed serum/plasma 700 school-age children from communities Gabon, Ghana, Ecuador, Netherlands Germany. IgG1 galactosylation levels were generally higher...