A5036676047- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Insects and Parasite Interactions
- Child Nutrition and Water Access
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Health Systems, Economic Evaluations, Quality of Life
- Insect symbiosis and bacterial influences
- Health Policy Implementation Science
- Music Technology and Sound Studies
- Economic and Environmental Valuation
- Safety Warnings and Signage
- Evaluation and Performance Assessment
- Cannabis and Cannabinoid Research
- Pregnancy and Medication Impact
- Mycobacterium research and diagnosis
- Schizophrenia research and treatment
- Helminth infection and control
- Substance Abuse Treatment and Outcomes
- COVID-19 epidemiological studies
- Community Health and Development
- Tuberculosis Research and Epidemiology
- Pharmaceutical Economics and Policy
- Food Security and Health in Diverse Populations
GlaxoSmithKline (United Kingdom)
2010-2022
University of Edinburgh
2020
Community Partners
2009
American Samoa Community College
2009
Centers for Disease Control and Prevention
2009
Atlanta Research and Education Foundation
2009
GlaxoSmithKline (Netherlands)
2008-2009
University of California, San Francisco
2002
In its first 8 years, the Global Programme to Eliminate Lymphatic Filariasis (GPELF) achieved an unprecedentedly rapid scale-up: >1.9 billion treatments with anti-filarial drugs (albendazole, ivermectin, and diethylcarbamazine) were provided via yearly mass drug administration (MDA) a minimum of 570 million individuals living in 48 83 initially identified LF-endemic countries.To assess health impact that this massive global effort has had, we analyzed benefits accrued from preventing or...
Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when prevalence levels decreased a that MDA can be discontinued without threat recrudescence. six-country study was conducted assessing performance seven tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community...
Background Between 2000–2007, the Global Programme to Eliminate Lymphatic Filariasis (GPELF) delivered more than 1.9 billion treatments nearly 600 million individuals via annual mass drug administration (MDA) of anti-filarial drugs (albendazole, ivermectin, diethylcarbamazine) all at-risk for 4–6 years. Quantifying resulting economic benefits this significant achievement is important not only justify resources invested in GPELF but also fully understand Programme's overall impact on some...
As the Global Programme to Eliminate Lymphatic Filariasis (LF) approaches its 2020 goal, an increasing number of districts will enter endgame phase where drug coverage rates from mass administration (MDA) are used assess whether MDA can be stopped. reported, gap between reported and actual in some contexts has overestimated true rates, thus causing premature transmission assessment surveys (TAS) that detect ongoing LF transmission. In these cases, must continue with additional rounds MDA....
The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000. To understand why some national programs have been more successful than others, a panel of individuals with expertise LF elimination efforts met assess available data from 8 countries. goal identify: 1) the factors determining success for (defined as rapid, sustained reduction microfilaremia/antigenemia after repeated mass drug administration [MDA]); 2) priorities operational research enhance efforts. Of 40...
Abstract Background The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000 with the goal of eliminating lymphatic filariasis (LF) as a public health problem by 2020. Despite considerable progress, current prevalence is around 60% figure, deadline looming year away. Consequently, there continued need for investment both mass drug administration (MDA) and morbidity management programs, this paper aims demonstrate that estimating economic burdens LF prior MDA...
Public health interventions based on distribution of anthelminthic drugs against lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminthiasis (STH) and schistosomiasis have been implemented separately to date. A better use available resources might be facilitated by a more coordinated approach control such infections, including the possibility co-administering three recommended through single, large-scale intervention.Ivermectin, albendazole praziquantel were co-administered...
Lymphatic filariasis (LF), also known as elephantiasis, is a neglected tropical disease (NTD) targeted for elimination through Global Programme to Eliminate LF (GPELF). Between 2000 and 2014, the GPELF has delivered 5.6 billion treatments over 763 million people. Updating estimated health economic benefits of this significant achievement important in justifying resources investment needed eliminating LF.We combined previously established models estimate number clinical manifestations...
Background The lymphatic filarial parasite Brugia timori occurs only in eastern Indonesia where it causes high morbidity. absence of an animal reservoir, the inefficient transmission by Anopheles mosquitoes and sensitivity to DEC/albendazole treatment make this species a prime candidate for elimination mass drug administration (MDA). Methodology/Principal Findings We evaluated effect MDA using DEC albendazole on B. soil transmitted helminths (STH) cross-sectional study sentinel village Alor...
Journal Article Assessing the risk of benzimidazole therapy during pregnancy Get access Mark Bradley, Bradley SmithKline Beecham Pharmaceuticals, SB House, Great West Road, Brentford TW8 9BD, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar John Horton Transactions The Royal Society Tropical Medicine and Hygiene, Volume 95, Issue 1, January-February 2001, Pages 72–73, https://doi.org/10.1016/S0035-9203(01)90338-4 Published: 01 January 2001 history Received:...
Assessing the interruption of lymphatic filariasis transmission after annual mass drug administration (MDA) requires a better understanding how to interpret results obtained with available diagnostic tools. We conducted parasitologic, serologic, and entomologic surveys in three villages American Samoa sentinel site suggested filarial antigen prevalence was < 1% five MDAs diethylcarbamazine albendazole. Antigen antifilarial antibody ranged from 3.7% 4.6% 12.5% 14.9%, respectively, by...
Background In 1997, the World Health Assembly adopted Resolution 50.29, committing to elimination of lymphatic filariasis (LF) as a public health problem, subsequently targeted for 2020. The initial estimates were that 1.2 billion people at-risk LF infection globally. Now, 13 years after Global Programme Eliminate Lymphatic Filariasis (GPELF) began implementing mass drug administration (MDA) against in 2000—during which over 4.4 treatments have been distributed 56 endemic countries—it is...
It has been estimated that $154 million per year will be required during 2015-2020 to continue the Global Programme Eliminate Lymphatic Filariasis (GPELF). In light of this, it is important understand program's current value. Here, we evaluate cost-effectiveness and cost-benefit preventive chemotherapy was provided under GPELF between 2000 2014. addition, also investigate potential hydrocele surgery.Our economic evaluation based on previously published health impact estimates (between 2014)....
Neglected tropical diseases (NTDs) are targeted for global control or elimination. Recognising that the populations most in need of medicines to target NTDs those least able support and sustain them financially, pharmaceutical industry created mechanisms donating expertise affected countries through partnerships with WHO, development agencies, non-governmental organisations philanthropic donors. In last 30 y, companies have established programmes donate 17 different overcome burden NTDs....
Entomologic monitoring of filarial infections, xenomonitoring, may have advantages in certain epidemiologic situations to assess the presence infections humans. Hemalum staining and dissection polymerase chain reaction (PCR) were compared determine infection status Aedes (Stegomyia) mosquitoes American Samoa. The overall prevalences Wuchereria bancrofti Dirofilaria immitis Ae. polynesiensis were, respectively, 0.16% 1.06% by 0.69% 1.77% PCR. Human worm DNA rates aegypti upolensis 1.16%...
Abstract Background Lymphatic filariasis (LF) is a neglected tropical disease (NTD). In 2000 the World Health Organization (WHO) established Global Programme to Eliminate Filariasis (GPELF). A key component of this programme mass drug administration (MDA). Between and 2020, GPELF has delivered over 8.6 billion treatments at-risk populations. The last impact assessment evaluated provided between 2000–2014. goal analysis provide an updated health programme, based on numbers treated 2000–2020....
During its first 8 years, the Global Programme to Eliminate Lymphatic Filariasis provided more than 1900 million treatments with antifilarial drugs (albendazole, ivermectin and diethylcarbamazine) at least 570 people in 48 countries endemic lymphatic filariasis (LF). As a result of this impressive global effort an unprecedented public-private partnership, years mass drug administration (MDA) have prevented spread filarial infection estimated 6.6 newborns, stopped progression clinical...
Albendazole (ABZ) is used in several anthelminthic drug programs. ABZ side-effects are generally mild, but ABZ-induced pancytopenia may be serious. In filariasis programmes, it necessary to administer breastfeeding women. Few data available on safety of for breastfed infants. addition, the pharmacokinetics and its metabolites human milk insufficiently investigated. The aim was study [ABZ sulphoxide (ABSX) sulphone] breast lactating women after one single oral dose ABZ.
We suggest and illustrate from our experiences of integration in a public health context Indonesia, reframing for mixed methods research that focuses on context, outcomes, objects, integrative mechanisms. Through describing the tools conceptualizations helped us integrate, we argue expanding scope to include social process (which describe) rethinking desired outcomes integration. The article contributes field by proposing: (a) new framing supports greater precision as well an expanded over...
The global decline in prevalence of lymphatic filariasis has been one the major successes WHO's NTD programme. recommended strategy intensive, community-wide mass drug administration, aims to break localised transmission by either reducing microfilaria positive infections below 1%, or antigen 2%. After threshold is reached, and administration stopped, geographically defined evaluation units must pass Transmission Assessment Surveys demonstrate that interrupted. In this study, we use an...