A5060304479- Substance Abuse Treatment and Outcomes
- Schizophrenia research and treatment
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Neurotransmitter Receptor Influence on Behavior
- Opioid Use Disorder Treatment
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Treatment of Major Depression
- Alcohol Consumption and Health Effects
- Sleep and related disorders
- Posttraumatic Stress Disorder Research
- Hepatitis C virus research
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Pharmacological Effects and Toxicity Studies
- Gambling Behavior and Treatments
- Traumatic Brain Injury Research
- Liver Disease and Transplantation
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- HIV Research and Treatment
VA San Diego Healthcare System
2025
National Center for PTSD
2025
National Center for Post Traumatic Stress Disorder
2025
University of California, San Francisco
2015-2024
San Francisco VA Medical Center
2013-2024
San Francisco VA Health Care System
2017-2024
Northern California Institute for Research and Education
2013-2023
Government of the United States of America
2023
San Francisco Department of Public Health
2015-2022
Unity Health System
2015-2017
<h3>Importance</h3> Selecting effective antidepressants for the treatment of major depressive disorder (MDD) is an imprecise practice, with remission rates about 30% at initial treatment. <h3>Objective</h3> To determine whether pharmacogenomic testing affects antidepressant medication selection and such leads to better clinical outcomes. <h3>Design, Setting, Participants</h3> A pragmatic, randomized trial that compared guided by vs usual care. Participants included 676 clinicians 1944...
Alcohol and nicotine dependence are common in schizophrenia. Varenicline is effective smoking cessation has also been shown to decrease alcohol consumption smokers. The present pilot study assessed the safety effectiveness of varenicline for treatment concurrent Outpatients with schizophrenia or schizoaffective disorder were enrolled this 8-week, double-blind, randomized, placebo-controlled trial. use using self-report (Timeline Follow-Back) biological measures. Adverse events recorded....
Methamphetamine use is increasingly prevalent and associated with HIV transmission. A previous phase 2a study of mirtazapine demonstrated reductions in methamphetamine sexual risk behaviors among men who have sex men.To determine the efficacy for treatment disorder reduction behaviors.This double-blind randomized clinical trial vs placebo took place from August 2013 to September 2017 an outpatient research clinic San Francisco, California. Participants were community-recruited adults...
Bipolar mood disorder (BP) is a debilitating syndrome characterized by episodes of mania and depression. We designed multistage study to detect all major loci predisposing severe BP (termed BP-I) in two pedigrees drawn from the Central Valley Costa Rica, where population largely descended few founders 16th–18th centuries. considered only individuals with BP-I as affected screened genome for linkage 473 microsatellite markers. used model analysis that incorporated high phenocopy rate...
Nineteen patients seen at a psychiatric emergency service with amphetamine‐ or cocaine‐induced psychotic disorder were assessed structured interviews, chart review, and blood urine testing. All had predominance of positive symptoms from the Positive Negative Syndrome Scale (PANSS). However, some subjects substantial scores (26%), bizarre delusions (95%), Schneiderian hallucinations (63%), mimicking broad range schizophrenic symptoms. Several PANSS correlated treatment intensity: score...
Background The course of posttraumatic stress disorder ( PTSD ) is frequently and severely complicated by co‐occurring alcohol use AUD ), yet there are few reports pharmacologic treatments for these comorbid conditions. objective this pilot study was to obtain a preliminary assessment the efficacy safety topiramate in reducing symptoms veterans with both disorders. Methods This prospective 12‐week, randomized, double‐blind, placebo‐controlled trial flexible‐dose up 300 mg/d 30 . primary...
Management of cirrhosis is challenging and has been complicated by the COVID-19 pandemic due to decreased access care, increased psychological distress, alcohol misuse. Recently, The National Institute on Alcohol Abuse Alcoholism broadened definition recovery from use disorder include quality life (QoL) as an indicator recovery. This study examined associations alcohol-associated etiology problematic drinking with liver disease QoL (LDQoL).
Cocaine abuse is a common clinical problem among opioid-dependent patients who are in methadone maintenance treatment. In an open prospective study, 16 DSM-III-R, cocaine-dependent, treatment were treated with fluoxetine, at mean dose of 45 mg/day for 9 weeks. Eleven subjects (69%) infected the human immunodeficiency virus. use was significantly reduced by end treatment, although most did not achieve abstinence. Comparison intake to week showed significant decrease self-reported cocaine use,...
Posttraumatic stress disorder (PTSD) and alcohol use (AUD) frequently co-occur. Prolonged exposure (PE) is an effective treatment for PTSD but shows smaller effects in patients with co-occurring AUD. Topiramate may help reduce symptoms. This double-blind, placebo-controlled outpatient clinical trial compared 12 sessions of PE plus either topiramate or placebo. One hundred U.S. veterans (mean age=45 years [SD=12], 84% men) PTSD+AUD were randomly assigned to 16 weeks PE+topiramate (up 250 mg)...
OBJECTIVE: The study determined whether dispositions from an urban psychiatric emergency service would differ between patients who received a mandatory urine drug test and those may or not have had based on the attending psychiatrist's clinical judgment. accuracy of clinicians' suspicion substance use among mandatorily screened was also examined. METHODS: A total 392 consenting presenting to were randomly assigned mandatory-screen group (N=198) usual-care (N=194). Physicians ordered screens...
Abstract This paper describes two clinical techniques aiming to improve adherence medications for HIV/AIDS in methadone maintenance patients. The first technique, providing on-site dispensing of antiretroviral medications, enhanced medication but did not produce enduring effects beyond the time intervention. To develop a more long-lasting intervention, programme is experimenting with individualized management, which staff member provides assessment and problem solving help adherence....
Posttraumatic stress disorder (PTSD), chronic pain, and substance use disorders are prevalent co-occurring conditions that challenging to treat individually, there is no evidence-based treatment for all 3. Buprenorphine, used opioid a partial nociceptin receptor agonist. In preclinical studies, agonist was shown mitigate PTSD symptoms in acute trauma. We compared buprenorphine other medications its impact on patients with pain and/or disorders.We assembled retrospective cohort of 382 Iraq...
This study describes the relationship between need for psychiatric consultation, illicit drug use, and zidovudine (AZT) adherence in HIV-infected injection users (IDUs) methadone maintenance treatment (MMT). The records of 57 IDUs MMT who had been prescribed AZT May August 1991 were reviewed. Those required consultation (P+, N = 46, 81%) compared with those did not require (P-, 11, 19%) on to (using mean corpuscular volume [MCV] as a biological marker), recent CD4 lymphocyte (T cell) count...
Two studies were conducted to examine the practical implementation of an integrated health care model in five primary clinics Upstate New York Veterans Affairs (VA) system. The aims were: (a) describe basic clinical elements service offered by behavioral providers (BHPs) setting, and (b) evaluate perceptions patients regarding practices their clinics. In Study 1, we reviewed 180 electronic medical records who met with a BHP care. 2, used semistructured interviews self-report questionnaires...