A5053232923- Forensic and Genetic Research
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Romani and Gypsy Studies
- Malaria Research and Control
- Mosquito-borne diseases and control
- Archaeology and ancient environmental studies
- Race, Genetics, and Society
- Hepatitis C virus research
- Chromosomal and Genetic Variations
- Parasites and Host Interactions
Barcelona Institute for Global Health
2024-2025
Institut de Biologia Evolutiva
2017-2022
Universitat Pompeu Fabra
2017-2022
Abstract Targeted amplicon sequencing is a powerful and efficient tool to interrogate the P . falciparum genome generate actionable data from infections complement traditional malaria epidemiology. For maximum impact, genomic tools should be multi-purpose, robust, sensitive reproducible. We developed, characterized, implemented MAD 4 HatTeR, an panel based on Multiplex Amplicons for Drug, Diagnostic, Diversity, Differentiation Haplotypes using Resequencing, along with bioinformatic pipeline...
Targeted amplicon sequencing is a powerful and efficient tool for interrogating the Plasmodium falciparum genome, generating actionable data from infections to complement traditional malaria epidemiology. For maximum impact, genomic tools should be multi-purpose, robust, sensitive, reproducible. We developed, characterized, implemented MAD4HatTeR, an panel based on Multiplex Amplicons Drug, Diagnostic, Diversity, Differentiation Haplotypes using Resequencing, along with bioinformatic...
Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 chromosomes for six additional SNPs 17 Y-STRs population samples from Spain, Portugal France order further characterize this lineage and, particular, ascertain time place where originated, as well subsequent dynamics. found that present frequencies ~40% Iberian populations up 70% Basques, but...
E-M183 (E-M81) is the most frequent paternal lineage in North Africa and thus it must be considered to explore past historical demographical processes. Here, by using whole Y chromosome sequences from 32 African individuals, we have identified five new branches within E-M183. The validation of these variants more than 200 samples, which also information 13 Y-STRs, has revealed a strong resemblance among Y-STR haplotypes that pointed rapid expansion this haplogroup. Moreover, for first time,...
Abstract The Roma Diaspora—traditionally known as Gypsies—remains among the least explored population migratory events in historical times. It involved migration of ancestors out-of-India through plateaus Western Asia ultimately reaching Europe. demographic effects Diaspora—bottlenecks, endogamy, and gene flow—might have left marked molecular traces genomes. Here, we analyze whole-genome sequence 46 individuals pertaining to four migrant groups six European countries. Our analyses revealed a...
The Roma population is a European ethnic minority characterized by recent and multiple dispersals founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous genetic studies based on genome-wide data uniparental markers detected events West-Eurasian gene flow. However, to best of our knowledge, it has not been assessed whether these demographic...
Genomic reference databases of residing populations are available in different countries and regions. Since they represent the whole genetic diversity a geographical region, have wide applications, from biomedical studies to forensic identifications. Uniparentally transmitted portions genome specifically highly suitable for kinship analyses, mixed DNA cases ancestry inferences. We sampled 808 individuals currently Catalonia within GCAT cohort, which we generated high-quality mitochondrial...
The Y chromosome can yield a unique perspective into the study of human demographic history. However, due to repetitive nature part its sequence, only small set regions are suitable for variant calling and discovery from short-read sequencing data. These combined represent 8.9 Mbp or 0.14% diploid genome. Consequently, investing in whole-genome resolve Y-chromosome questions is poorly efficient. Here we use, as an alternative, target enrichment technology greatly increase effectiveness,...