A5087293839- Malaria Research and Control
- Antibiotic Resistance in Bacteria
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Research on Leishmaniasis Studies
- Bacterial biofilms and quorum sensing
- Viral Infections and Vectors
- Trypanosoma species research and implications
- vaccines and immunoinformatics approaches
Makerere University
2022-2025
Infectious Diseases Research Collaboration
2024-2025
Pseudomonas aeruginosa is a leading cause of nosocomial infections worldwide. It can produce range debilitating infections, have propensity for developing antimicrobial resistance, and present with variety potent virulence factors. This study investigated the sequence types (ST), phenotypic susceptibility profiles, resistance genes among clinical isolates from urinary tract skin soft tissue infections. Fifty-six P. were obtained six medical centers across five counties in Kenya between 2015...
Klebsiella pneumoniae is a globally significant opportunistic pathogen causing healthcare-associated and community-acquired infections. This study examined the epidemiology distribution of resistance virulence genes in clinical K. strains Kenya. A total 89 isolates were collected over six years from five counties Kenya analyzed using whole-genome sequencing bioinformatics. These obtained (62/89) infections (21/89), hospital environment (6/89). Genetic analysis revealed presence blaNDM-1...
Abstract Targeted amplicon sequencing is a powerful and efficient tool to interrogate the P . falciparum genome generate actionable data from infections complement traditional malaria epidemiology. For maximum impact, genomic tools should be multi-purpose, robust, sensitive reproducible. We developed, characterized, implemented MAD 4 HatTeR, an panel based on Multiplex Amplicons for Drug, Diagnostic, Diversity, Differentiation Haplotypes using Resequencing, along with bioinformatic pipeline...
<title>Abstract</title> Background: Molecular surveillance of drug-resistant <italic>Plasmodium falciparum</italic> is crucial for malaria control in endemic regions. Two targeted-resequencing tools, the Inversion Probe (MIP) drug resistance panel DR23K and Multiplexed Amplicons Drugs, Diagnostics, Diversity, Differentiation using High-Throughput Targeted Resequencing (MAD<sup>4</sup>HatTeR) panel, are widely used to detect genotypes. However, comparisons their performance genotyping...
<title>Abstract</title> Background: Histidine Rich Protein 2 (HRP2)/pan-Lactate Dehydrogenase (pLDH) combination Rapid Diagnostic Tests (RDTs) may address the shortcomings of RDTs that detect HRP2 alone. However, relative contribution possible causes discordant results (RDT-negative and microscopy-positive) performance in field settings are poorly quantified. Methods: This study utilized samples from two cross-sectional surveys conducted 32 districts at 64 sites across Uganda between...
Malaria remains a significant global health threat, with sub-Saharan Africa (SSA) bearing the highest burden of disease. Plasmodium falciparum is predominant species in region, leading to substantial morbidity and mortality. Despite intensified control efforts over last two decades, P. genetic diversity multiplicity infections (MOI) continue pose challenges malaria elimination region. This study assessed population structure areas low, medium, high transmission intensities Uganda. A total...
Targeted amplicon sequencing is a powerful and efficient tool for interrogating the Plasmodium falciparum genome, generating actionable data from infections to complement traditional malaria epidemiology. For maximum impact, genomic tools should be multi-purpose, robust, sensitive, reproducible. We developed, characterized, implemented MAD4HatTeR, an panel based on Multiplex Amplicons Drug, Diagnostic, Diversity, Differentiation Haplotypes using Resequencing, along with bioinformatic...
ABSTRACT Klebsiella pneumoniae is a globally significant opportunistic pathogen causing healthcare-associated and community-acquired infections. This study examined the epidemiology distribution of resistance virulence genes in clinical K. strains Kenya. Eighty-nine isolates were collected over six years from five counties Kenya analyzed using whole genome sequencing bioinformatics. These obtained (62/89) infections (21/89), hospital environment (6/89). Genetic analysis revealed presence bla...
<title>Abstract</title> <bold>Background:</bold> <italic>Plasmodium falciparum</italic> remains a significant public health challenge globally, especially in sub-Saharan Africa, where it accounts for 99% of the disease burden. Infection outcomes vary widely from asymptomatic to severe, influenced by factors such as parasite genetic diversity and multiplicity infection (MOI). This study utilized seven neutral microsatellite markers investigate MOI both symptomatic individuals Uganda....
<abstract> Visceral Leishmaniasis (VL) remains a major public health problem mainly affecting the poorest populations across Asia, Africa, Middle East, Europe, Southern and Central America. For seven-decade now, first-line drug of choice for leishmaniasis has been pentavalent antimonials. However, clinical value these drugs is threatened by emergence drug-resistant parasites. Clinical resistance to sodium stibogluconate (pentostam) challenge in Indian subcontinent, raising concerns endemic...