A5033609653- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Antibiotic Use and Resistance
- Vaccine Coverage and Hesitancy
- Blood donation and transfusion practices
- Travel-related health issues
- Child Nutrition and Water Access
- Birth, Development, and Health
- Health Policy Implementation Science
- Pharmaceutical and Antibiotic Environmental Impacts
- Viral Infections and Outbreaks Research
- Vector-borne infectious diseases
- Pneumonia and Respiratory Infections
- Parasitic Diseases Research and Treatment
- Child Nutrition and Feeding Issues
- COVID-19 diagnosis using AI
- Hemoglobinopathies and Related Disorders
- Community Health and Development
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Parasites and Host Interactions
- Bird parasitology and diseases
- Viral Infections and Vectors
- Diverse Scientific Research Studies
Malaria Consortium
2011-2023
Ministry of Health
2020
Médecins Sans Frontières
2009
Médecins Sans Frontières
2006
BackgroundSeasonal malaria chemoprevention (SMC) aims to prevent in children during the high transmission season. The Achieving Catalytic Expansion of SMC Sahel (ACCESS-SMC) project sought remove barriers scale-up seven countries 2015 and 2016. We evaluated project, including coverage, effectiveness intervention, safety, feasibility, drug resistance, cost-effectiveness.MethodsFor this observational study, we collected data on delivery, effectiveness, influence costs impact incidence...
There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate reductase (dhfr) genes P. falciparum populations Nigeria, but one previous study has recorded a novel dhps mutation at codon 431 among infections imported to the United Kingdom from Nigeria. To assess how widespread this is parasites different parts country consequently fill gap sulfadoxine-pyrimethamine (SP) resistance data we retrospectively analysed 1000 filter paper blood spots collected...
BackgroundThe potential effects of SARS-CoV-2 and Plasmodium falciparum co-infection on host susceptibility pathogenesis remain unknown. We aimed to establish the prevalence malaria describe clinical characteristics P in a high-burden setting.MethodsThis was an exploratory prospective, cohort study patients with COVID-19 who were admitted hospital Uganda. Patients all ages PCR-confirmed diagnosis infection had provided informed consent or assent consecutively enrolled from treatment centres...
In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing species reliably are needed. Such often based on the detection parasite lactate dehydrogenase (pLDH). Dawei, southern Myanmar, three pLDH RDTs (CareStart™ Malaria (Pan), CareStart™ (Pan, Pf) and OptiMAL-IT®)were evaluated in patients presenting with clinically suspected malaria. Each RDT was read independently by two readers. A subset microscopically confirmed had their repeated days 2, 7...
The diagnostic capacity of three malaria rapid tests (RDTs), NOW-Malaria-ICT, OptiMAL-IT, and Paracheck-Pf, was evaluated against expert microscopy in Colombia. We tested 896 patients, whom confirmed 139 P. falciparum, 279 vivax, 13 mixed P.f/P.v infections 465 negatives. Paracheck-Pf NOW-malaria-ICT were more accurate detecting falciparum (sensitivities 90.8% 90.1%, respectively) comparison with Optimal-IT (83.6%). NOW showed an acceptable Pf detection rate at low densities (< 500/microL),...
Antibiotic resistance is an issue of growing global concern. One key strategy to minimise further development the rational use antibiotics, by providers and patients alike. Through integrated community case management (iCCM), children diagnosed with suspected pneumonia are treated antibiotics; one component essential package reduce child mortality increase access health care for remote populations. clinical algorithms, supportive supervision training, iCCM also offers opportunity improve...
Despite known gender-specific differences in terms of prevalence, transmission and exposure to neglected tropical diseases (NTDs), there is limited discussion the influence gender NTD programmes interventions. There a paucity research on how interacts with service provision uptake. This study, part broader implementation Ethiopia, applied lens health seeking for five NTDs: lymphatic filariasis, podoconiosis, schistosomiasis, soil-transmitted helminth infection trachoma.The study was...
Malaria has a negative effect on the outcome of pregnancy. Pregnant women are at high risk severe malaria and haemolytic anaemia, which contribute 60-70% foetal perinatal losses. Peripheral blood smear microscopy under-estimates sequestered placental infections, therefore rapid diagnostic tests (RDTs) detecting histidine rich protein-2 antigen (HRP-2) in peripheral potential alternative. HRP-2 RDTs accuracy pregnancy (MIP >28 weeks gestation) Plasmodium falciparum (after childbirth) were...
Background Pneumonia is the leading infectious cause of mortality in children under five worldwide. Community-level interventions, such as integrated community case management, have great potential to reduce burden pneumonia, well other diseases, especially remote populations. However, there are still questions whether health workers (CHW) able accurately assess symptoms pneumonia and prescribe appropriate treatment. This research addresses limitations previous studies using innovative...
Malaria incidence in Myanmar has significantly reduced over recent years, however, completeness and timeliness of data remain a challenge. The first ever nationwide malaria infection seroprevalence survey was conducted 2015 to better understand epidemiology highlight gaps Annual Parasite Index (API) data. cross-sectional two-stage stratified cluster-randomised household from July-October 2015. Blood samples were collected members for ultra-sensitive PCR serology testing P . falciparum vivax...
Abstract Background Remaining Plasmodium falciparum cases in Cambodia are concentrated forested border areas and remote populations who hard to reach through passive case detection. A key approach these is active detection by mobile malaria workers (MMWs). However, this operationally challenging because of changing movement patterns the target population moving into less accessible areas. From January 2018 December 2020, a tailored package approaches was implemented three provinces...
Community engagement approaches that have impacted on health outcomes are often time intensive, small-scale and require high levels of financial human resources. They can be difficult to sustain scale-up in low resource settings. Given the reach services into communities income countries, system provides a valuable potentially sustainable entry point would allow for community interventions. This study explores process developing an embedded approach taking global challenge antibiotic...
Experience of seasonal malaria chemoprevention (SMC) is growing in the Sahel sub-region Africa, though there remains insufficient evidence to recommend a standard deployment strategy. In 2012, project was initiated Katsina state, northern Nigeria, design an appropriate and effective community-based delivery approach for SMC, consultation with local stakeholders. Formative research (FR) conducted locally explore potential feasibility acceptability SMC highlight information gaps practical...
Abstract Background Nigeria was among the first African countries to adopt and implement change of treatment policy for severe malaria from quinine artesunate. Seven years after health systems readiness quality inpatient case-management practices were evaluated in Kano State Nigeria. Methods A cross-sectional survey undertaken May 2019 at all public hospitals. Data collection comprised hospital assessments, interviews with workers data extraction medical files suspected patients admitted...
Abstract Background Antibiotic resistance is a global threat to human health, and inappropriate use of antibiotics in humans animals widely considered be key driver antibiotic resistant infections. growing rapidly low- and, particularly, middle-income countries. However, there little detailed understanding about practices related the within community settings such Here we aimed understand rural households across Cumilla district, Bangladesh, relation household members their domestic animals....
Community engagement (CE) interventions often explore and promote behaviour change around a specific challenge. Suggestions for should be co-produced in partnership with the community. To facilitate this, it is essential that intervention includes key content unpacks challenge of interest via multiple sources knowledge. However, where community lived experience academic evidence appear misaligned, tensions can within co-production dynamic CE. This specifically so context antimicrobial...
<h3>ABSTRACT</h3> Cambodia has made impressive progress in reducing malaria trends and, 2018, reported no malaria-related deaths for the first time. However, coronavirus disease (COVID-19) pandemic presents a potential challenge to country9s goal elimination by 2025. The path toward depends on sustained interventions prevent rapid resurgence, which can quickly set back any gains achieved. Malaria Consortium supported mobile workers (MMWs) engage with target communities build acceptance,...
The World Health Organization (WHO) recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment severe malaria and a single dose of artemether quinine, in that order preference as pre-referral when is not possible. Where injections are available, children under 6 years may be administered rectal artesunate. Although current guidelines Ethiopia recommend intra-rectal alternatively quinine at health posts, there currently no WHO...
Innovative strategies are needed to reduce malaria mortality in high burden countries like Nigeria. Given that one of the important reasons for this is delay receiving effective treatment, improved access such treatment critical. Intramuscular artesunate could be used at lower-level facilities given its proven efficacy, ease use and excellent safety profile. The objective study was therefore explore health workers' perspectives on possible intramuscular as definitive severe facilities,...
Abstract Objectives To investigate the consequence of restricting antimalarial treatment to febrile children that test positive a malaria rapid diagnostic ( MRDT ) only in an area intense transmission. Methods Febrile aged 3–59 months were screened with at health facilities south‐west Nigeria. ‐positive received artesunate–amodiaquine ASAQ ), while ‐negative treated based on clinical diagnosis non‐malaria illness. The primary endpoint was risk developing microscopy‐positive within 28 days...
Despite the uptake of parasitological testing into policy and practice, appropriate prescription anti-malarials artemisinin-based combination therapy (ACT) in accordance with test results is variable. This study describes a National Malaria Control Programme-led capacity building intervention which was implemented 10 States Nigeria. Using experience Niger State, this assessed effect on malaria diagnosis practices among febrile under-fives rural health facilities.The multicomponent consisted...
Abstract Background Although the global malaria burden is decreasing, there are still concerns about overdiagnosis of and danger misdiagnosis non-malaria causes fever. Clinicians continue to face challenge differentiating between these despite introduction rapid diagnostic tests (mRDTs). Aim To determine prevalence non-malaria-caused fever in children South-Western Nigeria. Methods Secondary analysis data obtained evaluate effect restricting antimalarial treatment positive mRDT rural urban...
Background: Our understanding of the potential impact SARS-CoV-2 and malaria co-infection on host susceptibility pathogenesis remains unclear. We determined prevalence describe consequences in a high burden setting.Methods: This was prospective cohort study hospitalized Covid-19 patients Uganda. Malaria diagnosis done using rapid diagnostic tests, microcopy molecular methods. Previous P. falciparum exposure assessed serologic responses to panel antigens multiplex bead assay. Additional...