A5058236091- Malaria Research and Control
- Mosquito-borne diseases and control
- Parallel Computing and Optimization Techniques
- Distributed and Parallel Computing Systems
- Global Maternal and Child Health
- Parasites and Host Interactions
- Embedded Systems Design Techniques
- Computational Drug Discovery Methods
- Viral Infections and Outbreaks Research
- Trypanosoma species research and implications
- Pneumonia and Respiratory Infections
- vaccines and immunoinformatics approaches
- Statistical Methods and Bayesian Inference
- HIV Research and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Child Nutrition and Water Access
- COVID-19 epidemiological studies
- Hemoglobinopathies and Related Disorders
- Influenza Virus Research Studies
- HIV/AIDS Research and Interventions
- Complement system in diseases
- Insect symbiosis and bacterial influences
- Research on Leishmaniasis Studies
- Insect and Pesticide Research
- Hepatitis C virus research
London School of Hygiene & Tropical Medicine
2016-2025
World Health Organization
1999-2023
Bayero University Kano
2022
Kaduna State University
2022
University of London
2008-2022
Ahmadu Bello University
2022
Eli Lilly (United States)
2019
University of Glasgow
2018
Ninewells Hospital
2018
Public Health England
2018
BackgroundSeasonal malaria chemoprevention (SMC) aims to prevent in children during the high transmission season. The Achieving Catalytic Expansion of SMC Sahel (ACCESS-SMC) project sought remove barriers scale-up seven countries 2015 and 2016. We evaluated project, including coverage, effectiveness intervention, safety, feasibility, drug resistance, cost-effectiveness.MethodsFor this observational study, we collected data on delivery, effectiveness, influence costs impact incidence...
Malaria control remains a challenge in many parts of the Sahel and sub-Sahel regions Africa.We conducted an individually randomized, controlled trial to assess whether seasonal vaccination with RTS,S/AS01E was noninferior chemoprevention preventing uncomplicated malaria two interventions combined were superior either one alone severe malaria-related outcomes.We randomly assigned 6861 children 5 17 months age receive sulfadoxine-pyrimethamine amodiaquine (2287 [chemoprevention-alone group]),...
Background The RTS,S/AS01E malaria vaccine (RTS,S) was introduced by national immunisation programmes in Ghana, Kenya, and Malawi 2019 large-scale pilot schemes. We aimed to address questions about feasibility impact, assess safety signals that had been observed the phase 3 trial included an excess of meningitis cerebral cases RTS,S recipients, possibility deaths among girls who received than controls, inform decisions wider use. Methods In this prospective evaluation, 158 geographical...
SummaryBackgroundIn Africa, the scale-up of malaria-control interventions has reduced malaria burden, but progress towards elimination stalled. Mass drug administration (MDA) is promising as a transmission-reducing strategy, evidence from low-to-moderate transmission settings needed. We aimed to assess safety, coverage, and effect three cycles MDA with dihydroartemisinin–piperaquine plus single, low-dose primaquine on Plasmodium falciparum incidence prevalence in southeast Senegal.MethodsWe...
Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit. To examine the effect of such on transmission, Gambian children with Plasmodium were treated standard regimens chloroquine or pyrimethamine-sulfadoxine alone in combination 1 3 doses artesunate. The to mosquitoes gametocytes peripheral blood was determined 4 7 days after treatment. Infection observed all...
<h3>AIM</h3> To determine the influence of placental malaria, maternal HIV infection, and hypergammaglobulinaemia on transplacental IgG antibody transfer. <h3>METHODS</h3> One hundred eighty materno-neonatal pairs from a Malawian population were assessed. Cord serum samples tested for total titres using nephelometry, specific to<i>Streptococcus pneumoniae</i>, measles, tetanus toxoid antibodies an enzyme linked immunsorbent assay (ELISA). <h3>RESULTS</h3> Multiple regression analyses showed...
Transplacental transfer of specific IgG antibodies was studied in 46 pairs human immunodeficiency virus type 1 (HIV-I)-seropositive women and their neonates 53 healthy HIV-seronegative mothers newborns. Neonatal maternal sera were assessed by nephelometry for total levels serum ELISA to herpes simplex (HSV), varicella-zoster (VZV), measles virus, tetanus toxoid, streptolysin O, Streptococcus pneumoniae capsular antigens. Placental VZV, measles, 0, S. decreased HIV infection. Maternal had an...
Background Many malaria vaccines are currently in development, although very few have been evaluated for efficacy the field. Plasmodium falciparum multiple epitope (ME)– thrombospondin-related adhesion protein (TRAP) candidate designed to potently induce effector T cells and so a departure from earlier field terms of their mechanism action. ME-TRAP encode polyepitope string TRAP sporozoite antigen. Two vaccine vectors encoding ME-TRAP, plasmid DNA modified vaccinia virus Ankara (MVA), when...
Previous studies have shown that in areas of seasonal malaria transmission, intermittent preventive treatment children (IPTc), targeting the transmission season, reduces incidence clinical malaria. However, these were conducted communities with low coverage insecticide-treated nets (ITNs). Whether IPTc provides additional protection to sleeping under an ITN has not been established.To assess whether ITN, we a randomised, double-blind, placebo-controlled trial sulphadoxine pyrimethamine (SP)...
Seasonal malaria chemoprevention, previously known as intermittent preventive treatment in children, is highly effective areas with a short transmission season. Here we assess seasonality incidence data and define predictor of based on rainfall. We then use spatial rainfall, endemicity population to identify likely have seasonal incidence, estimate the at risk burden where chemoprevention would be appropriate. that suitable for there are 39 million children under 5 years age, who experience...
Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), given each month during the transmission season, is recommended for children living in areas of Sahel where malaria highly seasonal. The recommendation SMC currently limited to under five years age, but, many seasonal transmission, burden older may justify extending this age limit. This study was done determine effectiveness Senegalese up ten age.SMC introduced into three districts over central...
Abstract Background In the pre-intervention year of a randomized controlled trial investigating protective effects house screening against malaria-transmitting vectors, multi-factorial risk factor analysis study was used to identify factors that influence mosquito entry. Methods Mosquitoes were sampled using CDC light traps in 976 houses, each on one night, Farafenni town and surrounding villages during malaria-transmission season The Gambia. Catches from individual houses both (a) left...
There is longstanding evidence that immunoglobulin G (IgG) has a role in protection against clinical malaria, and human antibodies of the cytophilic subclasses are thought to be particularly critical this respect. In cohort study, 286 Burkinabè children 6 months 15 years old were kept under malaria surveillance order assess protective antibody responses four antigens which currently being evaluated as vaccine candidates: apical membrane antigen 1 (AMA1), merozoite surface protein 1-19...
A randomized trial reported by Alassane Dicko and colleagues shows that intermittent preventive treatment for malaria in children who are protected from mosquitoes insecticide-treated bednets provides substantial protection malaria.
Antigen-specific antibody-mediated immune responses play an important role in natural protection against clinical malaria, but conflicting estimates of this association have emerged from immuno-epidemiological studies different geographical settings. This study was aimed at assessing a standardized manner the relationship between antibody to four malaria vaccine candidate antigens and cohort Ghanaian children. Standardized ELISA protocols were used measure isotype IgG subclass levels Apical...
Vaccination with the recombinant viral vectors chimpanzee adenovirus 63 followed by modified vaccinia Ankara both encoding malaria sequence ME-TRAP conferred 67% protection against infection Plasmodium falciparum in Kenyan adults.
<h2>Summary</h2><h3>Background</h3> Seasonal vaccination with the RTS,S/AS01<sub>E</sub> vaccine combined seasonal malaria chemoprevention (SMC) prevented in young children more effectively than either intervention given alone over a 3 year period. The objective of this study was to establish whether added protection provided by combination could be sustained for further 2 years. <h3>Methods</h3> This double-blind, individually randomised, controlled, non-inferiority and superiority, phase...