A5080513973- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Viral Infections and Outbreaks Research
- Parasites and Host Interactions
- Viral Infections and Vectors
- Computational Drug Discovery Methods
- HIV/AIDS Research and Interventions
- COVID-19 epidemiological studies
- Trypanosoma species research and implications
- Disaster Response and Management
- Parasite Biology and Host Interactions
- Poverty, Education, and Child Welfare
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Blood donation and transfusion practices
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- HIV-related health complications and treatments
- Clinical Reasoning and Diagnostic Skills
- Research on Leishmaniasis Studies
- Data-Driven Disease Surveillance
- Ophthalmology and Visual Health Research
- Pregnancy and preeclampsia studies
- Helminth infection and control
Ministry of Health
2018-2025
Centers for Disease Control and Prevention
2024
Makerere University
2002-2023
World Health Organization - Uganda
2021
Foundation for Innovative New Diagnostics
2012-2017
Malaria Consortium
2008-2012
African Palliative Care Association
2007
University of California, San Francisco
2003
San Francisco General Hospital
2003
University of California, Berkeley
2003
Background. Current malaria diagnostic tests, including microscopy and antigen-detecting rapid cannot reliably detect low-density infections. Molecular methods such as polymerase chain reaction (PCR) are highly sensitive but remain too complex for field deployment. A new commercial molecular assay based on loop-mediated isothermal amplification (LAMP) was assessed use. Methods. Malaria LAMP (Eiken Chemical, Japan) evaluated samples from 272 outpatients at a rural Ugandan clinic compared with...
Parasite-based diagnosis of malaria by microscopy requires laboratory skills that are generally unavailable at peripheral health facilities. Rapid diagnostic tests (RDTs) require less expertise, but accuracy under operational conditions has not been fully evaluated in Uganda. There also concerns about RDTs use the antigen histidine-rich protein 2 (HRP2) to detect Plasmodium falciparum, because this can persist after effective treatment, giving false positive test results absence infection....
Early and accurate diagnosis of malaria followed by prompt treatment reduces the risk severe disease in endemic regions. Presumptive is widely practised where microscopy or rapid diagnostic tests (RDTs) are not readily available. With introduction artemisinin-based combination therapy (ACT) for many low-resource settings, there need to target patients with parasitologically confirmed order improve quality care, reduce over consumption anti-malarials, drug pressure turn delay development...
Genotyping frequently is used to distinguish recrudescent from new infections in antimalarial drug efficacy trials, but methodology and interpretation of results have not been standardized. We compared the utility polymorphisms within 3 Plasmodium falciparum genes during a longitudinal trial Kampala, Uganda. Merozoite surface protein-1 (msp-1) merozoite protein-2 (msp-2) revealed greater diversity than glutamate-rich protein. Genotypes based on msp-1, msp-2, all combined were for 394 initial...
To compare the effectiveness of oral quinine with that artemether-lumefantrine in treating uncomplicated malaria children.Randomised, open label study.Outpatient clinic Uganda's national referral hospital Kampala.175 children aged 6 to 59 months malaria.Participants were randomised receive or administered by care givers at home.Primary outcomes parasitological cure rates after 28 days follow-up unadjusted and adjusted genotyping distinguish recrudescence from new infections. Secondary...
While feasibility of new health technologies in well-resourced healthcare settings is extensively documented, it largely unknown low-resourced settings. Uganda's decision to deploy and scale up malaria rapid diagnostic tests (mRDTs) public facilities at the community level provides a useful entry point for documenting field experience, acceptance, predictive variables technology acceptance use. These findings are important informing implementation technologies, plans, budgets national...
The Uganda National Malaria Control Programme recognizes the importance of minimizing effect malaria among pregnant women. Accordingly, strategies including intermittent preventive treatment in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) have been scaled up. Uptake IPTp-SP women Uganda, aged 15–49 years who had a live birth 2 preceding 2016 Demographic and Health Survey (UDHS) was determined factors associated with uptake optimal doses were identified. This secondary analysis UDHS...
Abstract Despite scale up of perinatal prevention mother-to-child transmission (PMTCT) HIV interventions, postnatal continuity comprehensive HIV/AIDS care, for both the mother and baby, remains a challenge in developing countries. We determined adherence to PMTCT program (PN-PMTCT) associated factors among mothers at public urban hospital Uganda. interviewed HIV-positive on discharge we PN-PMTCT by proportion that honored their return appointments end eight weeks postpartum. had focus group...
Introduction Severe malaria is a life-threatening medical emergency and requires prompt effective treatment to prevent death. There paucity of published information on current practices severe case management in sub-Saharan Africa; we evaluated the for Ugandan health facilities Methods Findings We did cross sectional survey, using multi-stage sampling methods, 11 districts eastern mid-western parts Uganda. The study instruments were adapted from WHO hospital care assessment tools. Between...
In Uganda, artemether-lumefantrine (AL) is first-line therapy and dihydroartemisinin-piperaquine (DP) second-line for the treatment of uncomplicated malaria. This study evaluated efficacy safety AL DP in management falciparum malaria measured prevalence molecular markers resistance three sentinel sites Uganda from 2018 to 2019.This was a randomized, open-label, phase IV clinical trial. Children aged 6 months 10 years with were randomly assigned or followed 28 42 days, respectively....
Background: Coronavirus disease 2019 (COVID-19) vaccination is crucial for healthcare workers (HCWs) and understanding their perspectives vital promoting vaccine uptake in communities.Aim: This study assessed factors influencing COVID-19 among HCWs Kampala, Uganda.Setting: A cross-sectional was done seven high-volume health facilities Kampala.Methods: questionnaire based on the Behavioural Social Drivers Model administered to 200 HCWs. Data were analysed using STATA version 17 identify...
The coronavirus disease 2019 (COVID-19) pandemic significantly impacted health systems worldwide. This study explored the effects of COVID-19 cascade on programmes in Uganda. conducted in-depth interviews with key informants involved Uganda's national response. A cross-sectional exploratory using qualitative approaches was carried out. purposive sample 30 from Ministry Health (MoH) and implementing partners were interviewed (May 2023 - June 2023). Interviews audio recorded analysed inductive...
Background Intermittent screening and treatment (IST) of malaria during pregnancy has been proposed as an alternative to intermittent preventive in (IPTp), where IPTp is failing due drug resistance. However, the antenatal parasitaemias are frequently very low, most appropriate test for IST not defined. Methodology/Principal Findings We conducted a multi-center prospective study 990 HIV-uninfected women attending ANC two different transmission settings at Tororo District Hospital, eastern...
Surveillance of molecular markers for key mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) has been proposed as a means predicting sulfadoxine/ pyrimethamine (SP) treatment outcomes Africa. This study assessed the association between DHFR DHPS standardized clinical children treated with SP uncomplicated malaria Kampala, Uganda. Two (DHFR Asn-108 Ile-51) were too common to be useful predictors. Three other Arg-59, Gly-437, Glu-540)...
On 20th September 2022, Uganda declared the 7th outbreak of Ebola virus disease (EVD) caused by Sudan strain following confirmation a case admitted at Mubende Regional Referral Hospital. Upon confirmation, Government immediately activated national incident management system to initiate response activities. Additionally, multi-country emergency stakeholder meeting was held in Kampala; convening Ministers Health from neighbouring Member States undertake cross-border preparedness and actions....
In Uganda, long-lasting insecticidal nets (LLIN) have been predominantly delivered through two public sector channels: targeted campaigns or routine antenatal care (ANC) services. Their combination in a mixed-model strategy is being advocated to quickly increase LLIN coverage and maintain it over time, but there little evidence on the efficiency of each system. This study evaluated delivery channels regarding retention use, estimated associated costs, contribute towards evidence-base Uganda....
Malaria has a negative effect on the outcome of pregnancy. Pregnant women are at high risk severe malaria and haemolytic anaemia, which contribute 60-70% foetal perinatal losses. Peripheral blood smear microscopy under-estimates sequestered placental infections, therefore rapid diagnostic tests (RDTs) detecting histidine rich protein-2 antigen (HRP-2) in peripheral potential alternative. HRP-2 RDTs accuracy pregnancy (MIP >28 weeks gestation) Plasmodium falciparum (after childbirth) were...
Lymphatic filariasis (LF) in Uganda is caused by Wuchereria bancrofti and transmitted anopheline mosquitoes. The mainstay of elimination has been annual mass drug administration (MDA) with ivermectin albendazole, targeted to endemic districts, but sporadic incomplete coverage. Vector control could potentially contribute reducing W. transmission, speeding up progress towards elimination. To establish whether the use long-lasting insecticidal nets (LLINs) can transmission a setting ongoing...
Despite global effort to scale up access antiretroviral therapy (ART), many people in need of HIV/AIDS care Uganda have not been reached. HIV testing and ART are widely offered as routine medical services data on emergency settings Sub-Saharan Africa is limited. We determined the prevalence eligibility for a unit at Mulago hospital.In cross-sectional study, we interviewed 223 patients who were systematically selected from patients' register October through December 2004. was routinely...
Malaria case management is a key strategy for malaria control. Effective coverage of parasite-based diagnosis (PMD) remains limited in endemic countries. This study assessed the health system's capacity to absorb PMD at primary care facilities Uganda. In cross sectional survey, using multi-stage cluster sampling, lower level (LLHF) 11 districts Uganda were 1) tools, 2) skills, 3) staff and infrastructure, 4) structures, systems roles necessary implementing PMD. Tools (microscopy and/or RDTs)...
The training of health workers in the use malaria rapid diagnostic tests (RDTs) is an important component a wider strategy to improve parasite-based diagnosis at lower level care facilities (LLHFs) where microscopy not readily available for all patients with suspected malaria. This study describes process and cost attain competence perform RDTs public system setting eastern Uganda. Health from 21 Uganda were given one-day central on case management, including practical skills how read...