A5035627669- Rabies epidemiology and control
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- Bat Biology and Ecology Studies
- Streptococcal Infections and Treatments
- Zoonotic diseases and public health
- Disaster Response and Management
- Microbial infections and disease research
- Poxvirus research and outbreaks
- Bartonella species infections research
- Bone fractures and treatments
- Insect and Pesticide Research
- Human-Animal Interaction Studies
- Veterinary Orthopedics and Neurology
- Hepatitis C virus research
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- COVID-19 epidemiological studies
- Veterinary Oncology Research
- Bacillus and Francisella bacterial research
- Yersinia bacterium, plague, ectoparasites research
Centers for Disease Control and Prevention
2009-2024
National Center for Emerging and Zoonotic Infectious Diseases
2021
Colorado State University
2018
National University of San Marcos
2018
Ahmadu Bello University
2009-2018
Although there are over 1,150 bat species worldwide, the diversity of viruses harbored by bats has only recently come into focus as a result expanded wildlife surveillance. Such surveys importance in determining potential for novel to emerge humans, and optimal management their habitats. To enhance our knowledge viral present bats, we initially surveyed 415 sera from African Central American bats. Unbiased high-throughput sequencing revealed presence highly diverse group bat-derived related...
Bats are reservoirs for emerging zoonotic viruses that can have a profound impact on human and animal health, including lyssaviruses, filoviruses, paramyxoviruses, severe acute respiratory syndrome coronaviruses (SARS-CoVs). In the course of project focused pathogen discovery in contexts where human-bat contact might facilitate more efficient interspecies transmission viruses, we surveyed gastrointestinal tissue obtained from bats collected caves Nigeria frequented by humans. Coronavirus...
Rabies is a neglected disease despite being responsible for more human deaths than any other zoonosis. A lack of adequate and dog surveillance, resulting in low prioritization, often blamed this paradox. Estimation methods are employed to describe the rabies burden when surveillance data not available, however these figures rarely based on country-specific data.In 2013 knowledge, attitudes, practices survey was conducted Uganda understand population, vaccination, risk factors improve...
Twice a year in southwestern Nigeria, during traditional bat festival, community participants enter designated caves to capture bats, which are then consumed for food or traded. We investigated the presence of Bartonella species Egyptian fruit bats (Rousettus aegyptiacus) and flies (Eucampsipoda africana) from these assessed whether infections had occurred persons surrounding communities. Our results indicate that harbor strains, multilocus sequence typing indicated probably represent novel...
Haiti, a Caribbean country of 10.5 million people, is estimated to have the highest burden canine-mediated human rabies deaths in Western Hemisphere, and one rates world. Haiti also poorest Hemisphere has numerous economic health priorities that compete for rabies-control resources. As result, primary actions, including canine vaccination programs, surveillance systems animal rabies, appropriate postbite treatment, not been fully implemented at national scale. After 2010 earthquake further...
Rabies perpetuates in Nigeria despite initiatives like the Regional Disease Surveillance System Enhancement Project, with evidence indicating suboptimal canine vaccination rates as a contributing factor. To inform effective planning of mass dog campaigns, it is crucial to understand factors associated variation rates. We conducted cross-sectional study 2022 vaccination. used stratified random sampling streets and dog-owning households survey 4162 from three states Federal Capital Territory...
Abstract Background On 20 September 2022, Uganda declared its fifth Sudan virus disease (SVD) outbreak, culminating in 142 confirmed and 22 probable cases. The reproductive rate (R) of this outbreak was 1.25. We described persons who were exposed to the virus, became infected, they led infection an unusually high number cases during outbreak. Methods In descriptive cross-sectional study, we defined a super-spreader person (SSP) as any with real-time polymerase chain reaction (RT-PCR) SVD...
Background Rabies is a viral disease of animals and people causing fatal encephalomyelitis if left untreated. Although effective pre- post-exposure vaccines exist, they are not widely available in many endemic countries within Africa. Since individuals these remain at risk infection, healthcare-seeking behaviors crucial preventing infection warrant examination. Methodology A rabies knowledge, attitudes, practices survey was conducted 24 geographically diverse sites Uganda during 2013 to...
Current post-exposure prophylaxis for rabies virus infection has several limitations in terms of supply, cost, safety, and efficacy. Attempts to replace human or equine immune globulins (HRIG ERIG) have been made by companies institutes. We developed potent monoclonal antibodies neutralize a broad spectrum viruses screening hybridomas received from the U.S. Centers Disease Control Prevention (CDC). Two kinds chimeric (chimeric #7 #17) were constructed cloning variable regions selected...
Abstract Using questionnaires and serologic testing, we evaluated bat lyssavirus exposure among persons in an area of Nigeria that celebrates a festival. Bats from festival caves underwent testing for phylogroup II lyssaviruses (Lagos virus, Shimoni Mokola virus). The enrolled households consisted 2,112 persons, whom 213 (10%) were reported to have ever had contact (having touched bat, having been bitten by or scratched bat) 52 (2%) bat. Of 203 participants with contact, 3 (1%) received...
Post-exposure prophylaxis (PEP) is highly effective in preventing disease progression of rabies when used timely and appropriate manner. The key treatment for PEP infiltration immune globulin (RIG) into lesion site after bite exposure, besides wound care vaccination. Unfortunately, however, RIG expensive its supply limited. Currently, several anti-rabies virus monoclonal antibody (mAb) products are under development as alternatives to RIG, two recently received regulatory approval India. In...
Background: The study was conducted to determine the potential role of dog markets in epidemiology rabies Kaduna. Methods: Thirty brain samples were collected from different dogs brought Kaduna State, Nigeria. tissues tested using several assays: Direct Rapid Immunohistochemistry Test (dRIT); Fluorescent Antibody (DFA); Mouse Inoculation (MIT); and a Reverse Transcriptase- Polymerase Chain Reaction (RT-PCR). Both apparently healthy clinically ill markets. Results: Fifteen (50%) positive for...
We report the first evidence of Shimoni bat virus (SHBV) and detection Lagos (LBV)and Mokola (MOKV) in bats from Nigeria. In total, 356 representing 7 genera 8 species, collected locations northern None brains screened by direct fluorescent antibody (DFAT) test were positive for <i>lyssavirus</i> antigens. Of 76 sera modified rapid focus inhibition (RFFIT) 24 (31.6%) had neutralizing activity; 22(29.0%) neutralized LBV, 6(7.9%) MOKV 18(23.7%) SHBV). Lyssaviruses may be...
The highest rate of human rabies deaths reported in the Americas is Haiti, and most these result from virus infections that occur after individuals are bitten by infected dogs do not receive post-exposure prophylaxis. One barrier to prevention Haiti a lack knowledge about this disease among healthcare professionals community members. During past 4 years, US Centers for Disease Control Prevention has collaborated with public health officials partners develop, test refine educational materials...
Abstract Background: On September 20, 2023, Uganda declared its 5 th Sudan virus disease (SVD) outbreak, culminating in 142 confirmed and 22 probable cases. The reproductive rate (R) of this outbreak was 1.25. We describe persons to whom exposure resulted an unusual number cases during the outbreak. Methods: defined a super-spreader person (SSP) as any with RT-PCR-confirmed SVD linked infection ≥13 other (10-fold R). reviewed illness narratives for SSPs collected through interviews....
Abstract Twice a year in southwestern Nigeria, during traditional bat festival, community participants enter designated caves to capture bats, which are then consumed for food or traded. We investigated the presence of Bartonella species Egyptian fruit bats (Rousettus aegyptiacus) and flies (Eucampsipoda africana) from these assessed whether infections had occurred persons surrounding communities. Our results indicate that harbor strains, multilocus sequence typing indicated probably...