A5003640752- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Rabies epidemiology and control
- Zoonotic diseases and public health
- Soybean genetics and cultivation
- Yersinia bacterium, plague, ectoparasites research
- Viral Infections and Vectors
- Plant Virus Research Studies
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Bat Biology and Ecology Studies
- Mosquito-borne diseases and control
- Microbial infections and disease research
- Nematode management and characterization studies
- Species Distribution and Climate Change
- Plant pathogens and resistance mechanisms
- COVID-19 epidemiological studies
- Animal Disease Management and Epidemiology
- Reproductive Biology and Fertility
- Recycling and Waste Management Techniques
- COVID-19 and Mental Health
- Sperm and Testicular Function
- Vector-Borne Animal Diseases
- Palliative Care and End-of-Life Issues
Centers for Disease Control and Prevention
2015-2024
National Center for Emerging and Zoonotic Infectious Diseases
2017-2024
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2023
Computer Emergency Response Team
2022
United States Department of Health and Human Services
2020
Government of the United States of America
2020
Oak Ridge Associated Universities
2011-2019
National Institute of Biomedical Research
2019
Ministère de l'Agriculture
2019
Oak Ridge Institute for Science and Education
2011-2019
The recent apparent increase in human monkeypox cases across a wide geographic area, the potential for further spread, and lack of reliable surveillance have raised level concern this emerging zoonosis. In November 2017, World Health Organization (WHO), collaboration with CDC, hosted an informal consultation on researchers, global health partners, ministries health, orthopoxvirus experts to review discuss African countries where been recently detected also identify components response that...
The largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel 1), and Singapore 1) became first human cases exported Africa, a related nosocomial transmission event confirmed human-to-human outside of Africa.Epidemiological molecular data for Nigerian were analyzed jointly better understand exportations temporal geographic context outbreak.Isolates all travelers Bayelsa case shared most recent...
On May 17, 2022, the Massachusetts Department of Public Health (MDPH) Laboratory Response Network (LRN) laboratory confirmed presence orthopoxvirus DNA via real-time polymerase chain reaction (PCR) from lesion swabs obtained a resident. Orthopoxviruses include Monkeypox virus, causative agent monkeypox. Subsequent PCR testing at CDC on 18 that patient was infected with West African clade virus. Since then, cases* have been reported by nine states. In addition, 28 countries and territories,†...
Response TeamMonkeypox is a rare, sometimes life-threatening zoonotic infection that occurs in west and central Africa.It caused by Monkeypox virus, an orthopoxvirus similar to Variola virus (the causative agent of smallpox) Vaccinia live component vaccines) can spread humans.After 39 years without detection human disease Nigeria, outbreak involving 118 confirmed cases was identified during 2017-2018 (1); sporadic continue occur.During September 2018-May 2021, six unrelated persons traveling...
During 2012, 2013 and 2015, we collected small mammals within 25 km of the town Boende in Tshuapa Province, Democratic Republic Congo. The prevalence monkeypox virus (MPXV) this area is unknown; however, cases human infection were previously confirmed near these collection sites. Samples from 353 (rodents, shrews, pangolins, elephant a potamogale, hyrax). Some rodents shrews captured houses where have recently been identified, but most trapped forests agricultural areas villages. Real-time...
Preparedness activities against highly transmissible viruses with high mortality rates have been highlighted during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Smallpox, caused by variola virus (VARV) infection, is transmissible, an estimated 30% mortality.
Monkeypox is a poorly described emerging zoonosis endemic to Central and Western Africa.Using surveillance data from Tshuapa Province, Democratic Republic of the Congo during 2011-2015, we evaluated differences in incidence, exposures, clinical presentation polymerase chain reaction-confirmed cases by sex age.We report 1057 confirmed cases. The average annual incidence was 14.1 per 100 000 (95% confidence interval, 13.3-15.0). higher male patients (incidence rate ratio comparing males...
As of October 28, 2022, a total 28,244* monkeypox (mpox) cases have been reported in the United States during an outbreak that has disproportionately affected gay, bisexual, and other men who sex with (MSM) (1). JYNNEOS vaccine (Modified Vaccinia Ankara vaccine, Bavarian Nordic), administered subcutaneously as 2-dose (0.5 mL per dose) series (with doses 4 weeks apart), was approved by Food Drug Administration (FDA) 2019 to prevent smallpox mpox disease (2); FDA Emergency Use Authorization...
Human monkeypox is caused by Monkeypox virus (MPXV), an Orthopoxvirus, previously rare in the United States (1). The first U.S. case of during current outbreak was identified on May 17, 2022 (2). As September 28, 2022, a total 25,341 cases have been reported States.* has disproportionately affected gay, bisexual, and other men who sex with (MSM) (3). JYNNEOS vaccine (Modified Vaccinia Ankara vaccine, Bavarian Nordic), administered subcutaneously as 2-dose (0.5 mL per dose) series doses 4...
Monkeypox (mpox) is a zoonotic disease caused by virus (MPXV), an Orthopoxvirus; the wild mammalian reservoir species not known. There are two genetic clades of MPXV: clade I and II (historically found in central west Africa, respectively), with only Cameroon reporting both (1). Human cases have historically been reported from 1) mostly rural, forested areas some African countries; 2) countries related to population migration or travel infected persons; 3) exposure imported mammals (2). The...
Clade I monkeypox virus (MPXV), which can cause severe illness in more people than clade II MPXVs, is endemic the Democratic Republic of Congo (DRC), but country has experienced an increase suspected cases during 2023-2024.In light 2022 global outbreak mpox, DRC raises concerns that could spread to other countries and underscores importance coordinated, urgent action support DRC's efforts contain virus.To date, no mpox have been detected outside Central Africa where endemic.CDC partners are...
Monkeypox, caused by a zoonotic orthopoxvirus, is endemic in Central and West Africa. Monkeypox has been sporadically reported the Republic of Congo. During March 22-April 5, 2017, we investigated 43 suspected human monkeypox cases. We interviewed case-patients collected dried blood strips vesicular crust specimens (active lesions), which tested for orthopoxvirus antibodies ELISA virus varicella zoster DNA PCR. An ecologic investigation was conducted around Manfouété, from 105 small mammals...
Monkeypox is a zoonotic disease caused by virus member of the genus Orthopoxvirus and endemic to Central Western African countries. Previous work has identified two geographically disjuct clades monkeypox based on analysis few genomes coupled with epidemiological clinical analyses; however, environmental geographic causes this differentiation have not been explored. Here, we expand previous phylogenetic studies analyzing larger set originating throughout Sub-Saharan Africa identify possible...
Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa caused by virus (MPXV), the most virulent Orthopoxvirus affecting humans since eradication of Variola (VARV). Many aspects MPXV transmission cycle, including natural host virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs MPXV, as serosurveillance data has confirmed circulation these rodent species [1,2]. In order to understand tissue tropism clinical signs associated...
School closures affected more than 55 million students across the United States when implemented as a strategy to prevent transmission of SARS-CoV-2, virus that causes COVID-19 (1). Reopening schools requires balancing risks for SARS-CoV-2 infection and staff members against benefits in-person learning (2). During December 3, 2020-January 31, 2021, CDC investigated in 20 elementary (kindergarten through grade 6) had reopened Salt Lake County, Utah. The 7-day cumulative number new cases...
In-person learning benefits children and communities (1).Understanding the context in which transmission of SARS-CoV-2, virus that causes coronavirus disease 2019 , occurs schools is critical to improving safety inperson learning.During December 1, 2020-January 22, 2021, Cobb Douglas Public Health (CDPH), Georgia Department (GDPH), CDC investigated SARS-CoV-2 eight public elementary a single school district.COVID-19 cases* among educators students were either self-reported or identified by...
Abstract Using data from 12 US health departments, we estimated mean serial interval for monkeypox virus infection to be 8.5 (95% credible 7.3–9.9) days symptom onset, based on 57 case pairs. Mean incubation period was 5.6 4.3–7.8) 35
Incidence of human monkeypox (mpox) has been increasing in West and Central Africa, including the Democratic Republic Congo (DRC), where virus (MPXV) is endemic. Most estimates pathogen's transmissibility DRC are based on data from 1980s. Amid global 2022 mpox outbreak, new needed to characterize virus' epidemic potential inform outbreak control strategies. We used R package vimes identify clusters laboratory-confirmed cases Tshuapa Province, DRC. Cases with both temporal spatial were...
In June of 2022, the U.S. Centers for Disease Control and Prevention (CDC) Mpox Response wanted timely answers to important epidemiological questions which can now be answered more effectively through infectious disease modeling. Infectious models have shown valuable tools decision making during outbreaks; however, model complexity often makes communicating results limitations makers difficult. We performed nowcasting forecasting 2022 mpox outbreak in United States using R package EpiNow2....
Cowpox virus (CPXV) is described as the source of first vaccine used to prevent onset and spread an infectious disease. It one earliest members genus Orthopoxvirus, which includes viruses that cause smallpox monkeypox in humans. Both historic current literature describe "cowpox" a disease with single etiologic agent. Genotypic data presented herein indicate CPXV not species, but composite several (up 5) species can infect cows, humans, other animals. The practice naming agents after host...
Monkeypox is a zoonotic disease endemic to central and western Africa, where it major public health concern. Although virus (MPXV) monkeypox in humans have been well characterized, little known about its natural history, or maintenance animal populations of sylvatic reservoir(s). In 2003, several species rodents imported from Ghana were involved outbreak the United States with individuals three African rodent genera (Cricetomys, Graphiurus, Funisciurus) shown be infected MPXV. Here, we...
Monkeypox virus (MPXV), a close relative of Variola virus, is zoonotic with an unknown reservoir. Interaction infected wildlife, bites from peri-domestic animals, and bushmeat hunting are hypothesized routes infection wildlife to humans. Using Risk Questionnaire, performed in monkeypox-affected areas rural Democratic Republic the Congo, we describe lifestyles demographics associated presumptive risk factors for MPXV infection. We generated two indices assess risk: Household Materials Index...