A5087520439- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Rabies epidemiology and control
- Herpesvirus Infections and Treatments
- Cancer Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Microbial infections and disease research
- Global Healthcare and Medical Tourism
- Clinical practice guidelines implementation
- Streptococcal Infections and Treatments
- Insect Pest Control Strategies
- Virology and Viral Diseases
- Bat Biology and Ecology Studies
- Management of metastatic bone disease
- Medical Imaging and Analysis
- Traumatic Ocular and Foreign Body Injuries
- Essential Oils and Antimicrobial Activity
- Probabilistic and Robust Engineering Design
- Bacterial Identification and Susceptibility Testing
- Medical Research and Treatments
- Surgical Simulation and Training
- Cutaneous Melanoma Detection and Management
- Multiple and Secondary Primary Cancers
- Prostate Cancer Diagnosis and Treatment
- Tendon Structure and Treatment
Centers for Disease Control and Prevention
2012-2024
National Center for Emerging and Zoonotic Infectious Diseases
2017-2024
Computer Emergency Response Team
2023
Northwestern University
2018-2021
University of Southern California
2018-2021
University of Virginia
2009-2011
Southern General Hospital
1975
Southbank Centre
1975
Rabies is a fatal zoonotic disease that requires fast, accurate diagnosis to prevent in an exposed individual. The current gold standard for post-mortem of human and animal rabies the direct fluorescent antibody (DFA) test. While DFA test has proven sensitive reliable, it high quality conjugates, skilled technician, fluorescence microscope diagnostic specimen sufficient quality. LN34 pan-lyssavirus real-time RT-PCR assay represents strong candidate diagnostics due its ability detect RNA...
Since May 2022, approximately 20,000 cases of monkeypox have been identified in the United States, part a global outbreak occurring 90 countries and currently affecting primarily gay, bisexual, other men who sex with (MSM) (1). Monkeypox virus (MPXV) spreads from person to through close, prolonged contact; small number occurred populations are not MSM (e.g., women children), testing is recommended for persons meet suspected case definition* CDC previously developed five real-time polymerase...
Abstract Background After months of few mpox cases, an increase in cases was reported Chicago during May 2023, predominantly among fully vaccinated (FV) patients. We investigated the outbreak scope, differences between and unvaccinated patients, hypotheses for monkeypox virus (MPXV) infection after vaccination. Methods interviewed patients reviewed medical records to assess demographic, behavioral, clinical characteristics; vaccine status; administration routes. evaluated serum antibody...
Myasthenia gravis is a human disease caused by an autoimmune response against the nicotinic acetylcholine receptor (AcChoR). Since molecular structure of AcChoR well known, myasthenia excellent system for studying recognition complex membrane antigen in immune system. Human T-helper (TH) cell lines reactive to were isolated from four myasthenic patients selection with native Torpedo californica. The selected TH cells could efficiently recognize and fully denatured AcChoR. vast majority...
Monkeypox (mpox) is a disease caused by an Orthopoxvirus. The 2022 multinational outbreak, which began in May 2022, has spread primarily close skin-to-skin contact, including through sexual contact. Persons experiencing homelessness have been disproportionately affected severe mpox (1). However, prevalence and transmission pathways among persons are not known, specifically recommended to receive vaccine during the outbreak (2,3). During October 25-November 3, CDC field team conducted...
Abstract We assessed mpox virus prevalence in blood, pharyngeal, and rectal specimens among persons without characteristic rash presenting for JYNNEOS vaccine. Our data indicate that the utility of risk-based screening skin lesions or via pharyngeal swabs, and/or blood is likely limited.
Rabies is an ancient neglected tropical disease that causes tens of thousands human deaths and millions cattle annually. In order to develop a new vaccine for potential use in bats, reservoir rabies infection humans animals alike, silico antigen designer tool was used create mosaic glycoprotein (MoG) gene using available sequences from the Phylogroup I glycoprotein. This sequence, which represents strains more likely occur cloned into raccoonpox virus (RCN) efficacy this novel RCN-MoG...
Since May 2022, mpox has been identified in 108 countries without endemic disease; most cases have gay, bisexual, or other men who sex with men. To determine number of missed cases, we conducted 2 studies during June-September 2022: a prospective serologic survey detecting orthopoxvirus antibodies among San Francisco, California, and retrospective monkeypox virus PCR testing swab specimens submitted for infectious disease all patients across the United States. The serosurvey 225 participants...
Knowledge about monkeypox transmission risk in congregate settings is limited. In July 2022, the Chicago Department of Public Health (CDPH) confirmed a case person detained Cook County Jail (CCJ) Chicago, Illinois. This was first identified correctional setting United States and reported to CDC during 2022 multinational outbreak. CDPH collaborated with CCJ, Illinois (IDPH), evaluate within facility. Fifty-seven residents were classified as having intermediate-risk exposures patient 7-day...
Following rabies virus (RABV) exposure, a combination of thorough wound washing, multiple-dose vaccine administration and the local infiltration immune globulin (RIG) are essential components modern post-exposure prophylaxis (PEP). Although cell-culture-based vaccines increasingly used in many countries, RIG is much less available. The prohibitive cost polyclonal serum products has prompted search for alternatives design anti-RABV monoclonal antibodies (MAbs) that can be manufactured on...
Abstract Background The extent to which infections may have been undetected in an epicenter of the 2022 mpox outbreak is unknown. Methods A serosurvey (July and August 2022) assessed seroprevalence correlates infection among a diverse sample asymptomatic patients with no prior diagnoses known histories smallpox or vaccination. We present seropositivity stratified by participant characteristics collected via survey. Results Two-thirds 419 participants were cismen (281 419), whom 59.1% (166...
Abstract Human rabies remains a globally significant public health problem. Replacement of polyclonal anti-rabies immunoglobulin (RIG), passive component post-exposure prophylaxis (PEP), with monoclonal antibody (MAb), would eliminate the cost and availability constraints associated RIG. Our team has developed licensed human RAB1 (Rabishield © ), as replacement for RIG where canine is enzootic. However, highly diverse viruses North America, cocktail containing two or more MAbs targeting...
Summary Zoonotic disease surveillance is typically initiated after an animal pathogen has caused in humans. Early detection of potentially high‐risk pathogens within hosts may facilitate medical interventions to cope with emerging disease. To effectively spillover a novel host, undergo genetic changes resulting varying transmission potential the new host and Rabies virus (RABV) one model consider for studying dynamics infectious diseases under both laboratory field conditions. The...
Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and properties associated with its ribonuclease activity. TMR-001, a proprietary bulk drug substance solution of ranpirnase, was evaluated against virus in three cell types: mouse neuroblastoma, BSR (baby hamster kidney cells), bat primary fibroblast cells. When TMR-001 added to monolayers 24 h preinfection, release inhibited for all types at time points postinfection. treatment simultaneous...
Abstract A healthcare provider unknowingly treated a patient with mpox and subsequently developed ocular without rash. She breastfed during illness; her infant was not infected. This report addresses 3 challenges in management control: diagnosis the absence of rash, exposures settings, lactating patients.
People experiencing homelessness (PEH) are underrepresented in public health and clinical research. Study methods that can improve participation by this group needed.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeasonal patterns and pesticidal effects on the phototoxic linear furanocoumarins in celery, Apium graveolens LJohn T. Trumble, Jocelyn G. Millar, Daniel E. Ott, William C. CarsonCite this: J. Agric. Food Chem. 1992, 40, 9, 1501–1506Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September...
Current post-exposure prophylaxis for rabies virus infection has several limitations in terms of supply, cost, safety, and efficacy. Attempts to replace human or equine immune globulins (HRIG ERIG) have been made by companies institutes. We developed potent monoclonal antibodies neutralize a broad spectrum viruses screening hybridomas received from the U.S. Centers Disease Control Prevention (CDC). Two kinds chimeric (chimeric #7 #17) were constructed cloning variable regions selected...
Immunocontraceptive vaccines may be an alternative to surgical sterilization. Dual rabies vaccination and dog population management is a helpful tool for prevention. A synthetic gonadotropin-releasing hormone (GnRH) peptide coupled carrier protein or T cell epitope efficacious in inducing immunocontraception variety of mammals. However, virus-vectored GnRH recombinant have advantages over the conjugation method. In previous vitro study, we were able insert GnRH-coding sequence into virus...
Journal Article Impact of Pesticides for Tomato Fruitworm (Lepidoptera: Noctuidae) Suppression on Photosynthesis, Yield, and Nontarget Arthropods in Strawberries Get access John T. Trumble, Trumble Search other works by this author on: Oxford Academic PubMed Google Scholar W. Carson, Carson H. Nakakihara, Nakakihara V. Voth Economic Entomology, Volume 81, Issue 2, 1 April 1988, Pages 608–614, https://doi.org/10.1093/jee/81.2.608 Published: 01 1988 history Received: 12 June 1987 Accepted: 26 October