A5000363177- Rabies epidemiology and control
- Virology and Viral Diseases
- Viral Infections and Vectors
- Poxvirus research and outbreaks
- Viral Infections and Outbreaks Research
- Microbial infections and disease research
- Bat Biology and Ecology Studies
- Academic integrity and plagiarism
- Circular RNAs in diseases
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Antibiotics Pharmacokinetics and Efficacy
- Herpesvirus Infections and Treatments
- GDF15 and Related Biomarkers
- Toxoplasma gondii Research Studies
- Venomous Animal Envenomation and Studies
- Nutrition and Health in Aging
- Veterinary Pharmacology and Anesthesia
- Human-Animal Interaction Studies
- Virus-based gene therapy research
- Pharmacovigilance and Adverse Drug Reactions
- Bacillus and Francisella bacterial research
- HIV, Drug Use, Sexual Risk
InterDigital (United Kingdom)
2025
Centers for Disease Control and Prevention
2008-2022
National Center for Emerging and Zoonotic Infectious Diseases
2018-2019
There is persuasive epidemiological and experimental evidence that dietary polyphenolic plant-derived compounds have anticancer activity. Many laboratories, including ours, reported such an effect in cancers of the gastrointestinal tract, lung, skin, prostate breast. The catechins are a group polyphenols found green tea, which one most commonly consumed beverages world. While preponderance data strongly indicates significant antitumorigenic benefits from tea catechins, potential molecular...
Bats are natural reservoirs for the majority of lyssaviruses globally, and unique among mammals in having exceptional sociality longevity. Given these facets, recognized status bats as rabies viruses (RABVs) Americas, individual may experience repeated exposure to RABV during their lifetime. Nevertheless, little information exists with regard within-host infection dynamics role immunological memory that result from abortive bats. In this study, a cohort big brown (Eptesicus fuscus) was...
Active surveillance involves systematically monitoring patients to seek detailed information about the occurrence of adverse events (AEs) following drug administration. The Seta technology was developed improve active AEs or pregnancy in low- and middle-income countries geographically challenging areas. actively solicits responses from participants via WhatsApp messages. study aimed determine whether facilitated reporting pregnancies Brazilian National Health Surveillance Agency (ANVISA)....
Abstract After a human rabies outbreak in southeastern Peru, we collected bats to estimate the prevalence of various species. Among 165 from 6 genera and 10 species, 10.3% were antibody positive; was similar vampire nonvampire bats. Thus, may also be source for Peru.
A captive colony of adult Big Brown Bats (Eptesicus fuscus) was experimentally infected with a rabies virus (RABV) variant isolated from the salivary glands naturally Bat and passaged once through murine neuroblastoma cell culture. were divided into 11 groups, which composed one to three noninfected individuals each. Twenty 38 animals intramuscularly both left right masseter muscles; they received total 103.2 median mouse intracerebral lethal dose (MICLD50) RABV variant. Experimental outcome...
Previous studies have investigated rabies virus (RABV) epizootiology in Brazilian free-tailed bats (Tadarida brasiliensis) natural cave roosts. However, little is known about geographic variation RABV exposure, or if the use of man-made roosts by this species affects enzootic infection dynamics within colonies. We sampled viral neutralizing antibodies at three bridge and multiple time points during reproductive season to investigate temporal roost exposure. report seropositive all age sex...
Abstract Background The rabies virus causes a fatal encephalitis and can be transmitted through organ transplantation. In 2013, man developed 18 months after receiving kidney from donor with rabies, who was not known to have been infected when the organs were procured. Three additional persons received same (liver, kidney, heart), all of whom vaccinated for before transplantation, post‐exposure prophylaxis ( PEP ) immune globulin 5 doses vaccine as soon diagnosis made in (18 their transplant...
Big brown bats (Eptesicus fuscus) are the most commonly encountered rabid bat in North America and represent an important source of wildlife rabies epizootics. Urban suburban colonies E. fuscus often evicted from their roosts houses, with poorly understood consequences for dispersal, population dynamics, virus transmission. We combined radiotelemetry mark-recapture enhanced surveillance to understand frequency exposure house-roosting assess potential behavioral responses eviction exacerbate...
Abstract Human rabies remains a globally significant public health problem. Replacement of polyclonal anti-rabies immunoglobulin (RIG), passive component post-exposure prophylaxis (PEP), with monoclonal antibody (MAb), would eliminate the cost and availability constraints associated RIG. Our team has developed licensed human RAB1 (Rabishield © ), as replacement for RIG where canine is enzootic. However, highly diverse viruses North America, cocktail containing two or more MAbs targeting...
Ebola virus (EBOV) is a highly lethal member of the Filoviridae family associated with human hemorrhagic disease. Despite being sporadic disease, it caused large outbreak in 2014-2016 West Africa and another recently Democratic Republic Congo. Several vaccine candidates are currently preclinical clinical studies but none stable without cold chain storage.We used preservation by vaporization (PBV), novel processing technology to heat-stabilize FiloRab1 (inactivated rabies-based vaccine),...
Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and properties associated with its ribonuclease activity. TMR-001, a proprietary bulk drug substance solution of ranpirnase, was evaluated against virus in three cell types: mouse neuroblastoma, BSR (baby hamster kidney cells), bat primary fibroblast cells. When TMR-001 added to monolayers 24 h preinfection, release inhibited for all types at time points postinfection. treatment simultaneous...
A captive colony of Brazilian free-tailed bats (Tadarida brasiliensis) was vaccinated with a commercial monovalent inactivated rabies virus (RABV) vaccine (RABVAC 1). Baseline neutralizing antibodies (VNA) and the response to vaccination were measured in 50 bats. Rabies VNA detected plasma 64% (27/42) that had been 1 yr prior, but only 19% (8/42) levels considered adequate. 63% (5/8) no record previous vaccination, suggesting natural RABV exposure before captivity. All demonstrated by 10...
Attenuated strains of rabies virus (RABV) have been used for oral vaccination wild carnivores in Europe and North America. However, some RABV vaccines caused clinical target animals. To improve the safety attenuated as an vaccine field use, strategies using selection escape mutants under monoclonal antibody neutralization pressure reverse genetics–defined mutations used. We tested safety, immunogenicity, efficacy one construct, ERA-g333, developed with genetics by intramuscular (IM) or (PO)...
The distribution of orthopoxviruses (OPXVs) across the North American continent is suggested to be widespread in a wide range mammalian hosts on basis serosurveillance studies. To address question whether carnivores northwestern Mexico are exposed naturally circulating OPXVs, wild were collected by live trapping within four different habitat types during fall 2013 and spring 2014 Janos Biosphere Reserve Chihuahua, Mexico. A total 51 blood samples was for testing. Anti-OPXV immunoglobulin G...
In veterinary and human medicine, gabapentin (a chemical analog of γ-aminobutyric acid) is commonly prescribed to treat postoperative chronic neuropathic pain. This study explored the pharmacokinetics oral subcutaneous administration at high (80 mg/kg) low (30 doses as a potential analgesic in black-tailed prairie dogs (Cynomys ludovicianus; n = 24). The 80 half maximal effective concentration (1.4 16.7 ng/mL) for this were extrapolated from pharmacokinetic efficacy studies rats, rabbits,...