A5052307656- Antibiotics Pharmacokinetics and Efficacy
- Veterinary Pharmacology and Anesthesia
- Sexual function and dysfunction studies
- COVID-19 and healthcare impacts
- Occupational Health and Safety Research
- Microbial infections and disease research
- Vector-borne infectious diseases
- Influenza Virus Research Studies
- Sexuality, Behavior, and Technology
- Thermal Regulation in Medicine
- Viral Infections and Vectors
- Burkholderia infections and melioidosis
- HIV/AIDS Research and Interventions
- Bacillus and Francisella bacterial research
- Drug-Induced Hepatotoxicity and Protection
- Chemical Looping and Thermochemical Processes
- Hypothalamic control of reproductive hormones
- Infection Control and Ventilation
- Chemical Safety and Risk Management
- Reproductive tract infections research
- Vector-Borne Animal Diseases
- Respiratory viral infections research
- Forensic Toxicology and Drug Analysis
Centers for Disease Control and Prevention
2016-2020
National Center for Emerging and Zoonotic Infectious Diseases
2014-2019
Abstract Background Injectable hormonal contraception may increase women's risk of HIV acquisition and can affect biological factors in animal models . We established, for the first time, a model to investigate whether combined oral contraceptives ( COC ) alter SHIV susceptibility macaques. Methods Seven pigtail macaques were administered monophasic levonorgestrel LNG )/ethinyl estradiol EE at 33% or 66% human dose 60 days. Menstrual cycling, vaginal epithelial thickness, other monitored...
Rickettsia slovaca is a tick-borne human pathogen that associated with scalp eschars and neck lymphadenopathy known as (TIBOLA) or Dermacentor-borne necrosis erythema (DEBONEL). Originally, R. was described in Eastern Europe, but since recognition of its pathogenicity, cases have been reported throughout Europe. European vertebrate reservoirs remain unknown, feral swine domestic goats found infected seropositive for this pathogen. Recently, rickettsial identical to identified in, isolated...
In veterinary and human medicine, gabapentin (a chemical analog of γ-aminobutyric acid) is commonly prescribed to treat postoperative chronic neuropathic pain. This study explored the pharmacokinetics oral subcutaneous administration at high (80 mg/kg) low (30 doses as a potential analgesic in black-tailed prairie dogs (Cynomys ludovicianus; n = 24). The 80 half maximal effective concentration (1.4 16.7 ng/mL) for this were extrapolated from pharmacokinetic efficacy studies rats, rabbits,...
Laboratory animal facilities aim to provide excellence in care and welfare support scientific research. Critical these goals is ensure a safe work environment for personnel comprising veterinary care, laboratory research, maintenance staff.Thus, performing occupational risk assessments allows evaluation of risks from identified hazards associated with variety tasks ongoing facilities.Herein, we present the development an assessment tool purposed capture dynamics performed facilities,...
Abstract Background An established macaque model to assess HIV interventions against penile transmission is currently not available. Physiological changes during erections may affect susceptibility infection and drug pharmacokinetics ( PK ). Here, we identify methods establish in macaques evaluate transmission, , efficacy under physiologic conditions. Methods Penile rigidity length were evaluated eight rhesus following rectal electrostimulation RES ), vibratory stimulation VS or...
Seasonal influenza is a contagious respiratory illness that annually affects millions of people worldwide. To identify currently circulating virus subtypes, the Centers for Disease Control and Prevention’s International Reagent Resource distributes World Health Organization (WHO) reagent kits, which are used globally by testing laboratories surveillance. The data generated kits aid in strain selection vaccine each season. use animals to produce high quality quantities antibodies critical...