A5103191924- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- Tuberculosis Research and Epidemiology
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- HIV-related health complications and treatments
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Suicide and Self-Harm Studies
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- LGBTQ Health, Identity, and Policy
- SARS-CoV-2 and COVID-19 Research
- Sex work and related issues
- Antifungal resistance and susceptibility
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Immunotherapy and Immune Responses
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Shanghai Public Health Clinical Center
2016-2025
Kunming University of Science and Technology
2024-2025
The First People's Hospital of Zhaoqing
2020-2025
Sanya University
2025
Hainan University
2025
Baotou Medical College
2016-2024
Shenyang Center for Disease Control and Prevention
2015-2024
Fudan University
2012-2024
Baotou Teachers College
2024
University of York
2009-2024
Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus that caused disease 2019 (COVID-19), use face masks has become ubiquitous in China and other Asian countries such as South Korea Japan. Some provinces municipalities have enforced compulsory mask policies public areas; however, China's national guideline adopted a risk-based approach offering recommendations for using among health-care workers general public. We compared by different health authorities...
Variable immune responses to hepatitis B virus (HBV) infection and recombinant HBV vaccines have been associated with polymorphisms in several genes within the human leukocyte antigen (HLA) complex. Analyses of polymerase chain reaction (PCR)-based genotyping data from 164 North American adolescents vaccinated products confirmed that HLA-DRB1*07 (relative odds [RO] = 5.18, P <.0001) immunodeficiency type 1 (HIV-1) (RO 3.91, <.001) were both nonresponse full-dose vaccination. Further...
ABSTRACT A hallmark of human immunodeficiency virus type 1 (HIV-1) pathogenesis is the rapid loss CD4 T cells leading to generalized immune dysfunction, including an exhausted CD8 cell phenotype. Understanding necessary factors that govern functional quality and protective potential antiviral responses would facilitate rational vaccine design improve therapeutic strategies combat persistent infections. Mouse models chronic viral infection demonstrate interleukin-21 (IL-21), produced...
Synaptic changes are closely associated with cognitive deficits. In addition, testosterone (T) is known to exert regulative effects on synaptic plasticity. T may improve deficits in Alzheimer's disease (AD) patients, but the underlying mechanisms of androgenic action performance remain unclear. The aim this study was thus examine protective mechanism attributed an AD senescence, accelerated mouse prone 8 (SAMP8) animal model. Using Golgi staining quantify dendritic spine density hippocampal...
Since the implementation of "treat all" policy in China 2016, there have been few data on prevalence transmitted drug resistance (TDR) China. In this study, we describe TDR patients newly diagnosed with human immunodeficiency virus (HIV) infection between 2016 and 2019 Shenyang city, Demographic information plasma samples from all reported HIV-infected individuals to were collected. The HIV pol gene was amplified sequenced for subtyping TDR. spread analyzed by inferring an molecular network...
ABSTRACT In HIV-1 infection, the early set-point viral load strongly predicts both transmission and disease progression. The factors responsible for wide spectrum of loads are complex likely reflect an interplay between transmitted virus genetically defined in transmitting source partner seroconverter. Indeed, analysis 195 pairs from Lusaka, Zambia, revealed that partners contributed only ∼2% variance seroconverters ( P = 0.046 by univariable analysis). multivariable models, seroconverting...
Tuberculosis infection still places a great burden on HIV-infected individuals in China and other developing countries. Knowledge of the survival patients with pulmonary tuberculosis (PTB) would provide important insights for clinical management this population, which remains to be well described current China. PTB admitted Shanghai Public Health Clinical Center from January 2011 December 2015 were retrospectively enrolled. In cohort, prognosis was estimated by Kaplan-Meier method, while...
The roles of immunodeficiency and combined antiretroviral therapy (cART) in shaping the gut microbiota HIV-1-infected subjects (HISs) have not been described thoroughly by time-series investigations. In this study, 36 antiretroviral-naïve HISs were enrolled to prospectively assess alterations fecal plasma markers microbial translocation inflammation with cART. At baseline, species α-diversity was significantly lower a CD4+ T cell count <300/mm3 than >300/mm3 (Shannon index: Median 2.557 vs....
Cognitive dysfunction in Alzheimer's disease is strongly associated with a reduction synaptic plasticity, which may be induced by oxidative stress. Testosterone beneficial learning and memory, although the underlying protective mechanism of testosterone on cognitive performance remains unclear. This study explored subcutaneous injection 0.75 mg bilateral injections amyloid beta 1–42 oligomers into lateral ventricles male rats. Morris water maze test results demonstrated that treatment...
Young people's mental health globally has been in decline. Because of their low perceived need, young services tend to be the first cut when budgets are reduced. There is a lack evidence on how reduction and opportunities for people associated with health. Additionally, this may magnified by place assets challenges place. The aim study explore trends measured GHQ-12 over time twelve regions UK. We estimated an interrupted series model using 2010 as break point from which there was shift...
Little is known about the epidemiological features of dyslipidemia among antiretroviral-naive HIV-infected individuals in China. We used a cross-sectional study design to estimate prevalence this population, and identify risk factors associated with presence dyslipidemia. One thousand five hundred eighteen 347 HIV-negative subjects China were enrolled during 2009 2010. Demographics medical histories recorded. After an overnight fast, serum samples collected measure lipid levels. Factors...
Introduction. Lamivudine plus dolutegravir (3TC/DTG) and bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) regimens are commonly used as first-line treatments for people living with human immunodeficiency virus (HIV) (PLWH) worldwide.Gap Statement. There limited comparative data on the antiviral activity safety between these in ART-naive PLWH, particularly China, where 3TC/DTG regimen was integrated into therapy 2021 gained broader adoption after its inclusion National Health...
The underlying mechanisms and diagnostic biomarkers for the progress of COVID-19 in HIV patients have not been fully elucidated. In this study, aim is to analyze metabolomic profiles HIV/AIDS co-infected with SARS-CoV-2 identify indicative co-infection. we conducted a retrospective cohort analysis peripheral blood samples collected from 30 (pc group) without (nc group). through non-targeted metabolomics lipidomics analysis, 77 differential metabolites were identified plasma compared nc...
<title>Abstract</title> <bold>Background</bold>: The objective of this study was to compare the clinical efficacy unilateral dual-channel spinal endoscopy (UBE) and percutaneous foraminoscopy (PELD) in treatment single-level disc herniation. <bold>Patients Methods:</bold> This recruited patients with lumbar herniation who were hospitalized surgery Department Zhaoqing First People's Hospital from January 2021 December 2023. A total 51 underwent minimally invasive endoscopy, including 23 UBE...
Long non-coding RNAs (lncRNAs), representing the RNA regions, constitute a significant portion of genomes in complex organisms. Recent studies suggest that some lncRNAs have capability to encode peptides. However, presence lncRNA-derived sORFs-encoded polypeotides (LSEPs) plants is not well understood. In this study, we developed multi-omics approach encompasses transcriptomics, translatomics (Ribo-seq), and proteomics identify LSEPs rice. Among 2764 identified lncRNAs, 42.69% were found be...
During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable quantitative trait that has clinical and epidemiological implications. Immunogenetic research established various human genetic factors, especially leukocyte antigen (HLA) variants, as independent determinants of VL set-point.To identify clarify HLA alleles are associated with either transient or durable immune control we evaluated the relationships class I II among 563 seroprevalent Zambians (SPs) who...
Objective: In a recent genome-wide association study of HIV-1-infected individuals in the Euro-CHAVI cohort, viral load set-point was strongly associated with genotypes defined by two single nucleotide polymorphisms (SNPs) (rs9264942 and rs2395029) within human major histocompatibility complex (MHC) region on chromosome 6. We attempted to confirm this finding African–Americans address whether these SNPs are linkage disequilibrium leukocyte antigen (HLA) class I alleles that mediate innate...
Intracarotid artery cold saline infusion (ICSI) is an effective method for protecting brain tissue, but its use limited because of undesirable secondary effects, such as severe decreases in hematocrit levels, well relatively brief duration. In this study, the authors describe and investigate effects a novel ICSI pattern (interrupted ICSI) relative to traditional (uninterrupted ICSI).Ischemic strokes were induced 85 male Sprague-Dawley rats by occluding middle cerebral 3 hours using...
Human leukocyte antigen alleles influence the immune response to HIV-1. Signal peptides cleaved from those bind HLA-E and mediate natural killer cell function. of HLA-A HLA-C proteins carry methionine (Met) at anchor position 2 (P2); HLA-B Met or threonine (Thr). Different P2 residues alter binding its cognate receptors may impact HIV-1 acquisition. Among Zambian couples (N = 566) serodiscordant for HIV-1, P2-Met accelerated acquisition in HIV-1-negative partner (relative hazard [RH], 1.79)....