A5100693997- HIV Research and Treatment
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- HIV-related health complications and treatments
- Retinal Development and Disorders
- HIV, Drug Use, Sexual Risk
- Monoclonal and Polyclonal Antibodies Research
- Retinal Diseases and Treatments
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
- Ocular Diseases and Behçet’s Syndrome
- Bacteriophages and microbial interactions
- Fungal Infections and Studies
- Glaucoma and retinal disorders
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Retinal and Optic Conditions
- Hepatitis B Virus Studies
- Hepatitis C virus research
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
First Hospital of China Medical University
2013-2025
Peking Union Medical College Hospital
2015-2025
Chinese Academy of Agricultural Sciences
2023-2025
Agricultural Genomics Institute at Shenzhen
2023-2025
Ministry of Agriculture and Rural Affairs
2025
Heilongjiang University of Chinese Medicine
2025
China Medical University
2015-2024
Beijing YouAn Hospital
2023-2024
Capital Medical University
2021-2024
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) CRF08_BC and CRF07_BC are two major recombinants descended from subtypes B′ C. Despite their massive epidemic impact in China, migration patterns divergence times remain unknown. Phylogenetic population genetic analyses were performed on 228 HIV-1 sequences representing CRF08_BC, CRF07_BC, subtype C strains different locations across India, Myanmar. Genome-specific rates of evolution estimated using a Bayesian Markov chain Monte Carlo...
We report here a novel HIV-1 circulating recombinant form (CRF55_01B) composed of CRF01_AE and subtype B, with four recombination breakpoints in the pol gene. CRF55_01B was identified from three epidemiologically unlinked men having sex (MSM) China, suggesting ongoing generation recombinants involving B lineages among MSM China.
Abstract Background Natural killer (NK) cells have emerged as pivotal players in innate immunity, especially the defense against viral infections and tumors. Killer immunoglobulin-like receptors (KIRs) – an important recognition receptor expressed on surface of NK regulate inhibition and/or activation after interacting with human leukocyte antigen (HLA) class I ligands. Various KIR genes might impact prognosis many different diseases. The implications KIR-HLA interaction HIV disease...
To investigate the epidemiological relationships between HIV-1 strains that are spread among men who have sex with (MSM) populations of 9 cities across China and to analyze origins divergence times major epidemic found in MSM population.A total 583 HIV-1-positive subjects were recruited from high-risk 2009 2011. Nucleotide sequences 1.0-kb pro-RT regions amplified sequenced. Phylogenetic Bayesian molecular clock analyses performed.The overall distribution genotypes was as follows: CRF01_AE,...
HIV CRF01_AE accounted for 84% of the recent infections among men who have sex with (MSM) in Liaoning Province northeastern China. strains were grouped into two distinct clusters (designated 1 and 2) that also detected other regions Phylodynamics study revealed these independently introduced population MSM China early mid-1990s. Our elucidated unique features dynamics interrelationships epidemics
Natural killer (NK) cells are the first line of defense against pathogens immune system and also play an important role in resistance HIV. The activating receptor NKG2C inhibitory NKG2A co-modulate function NK by recognizing same ligand, HLA-E. However, on viral set point prediction HIV disease progression have been rarely reported. In this study, we determined expression or surface from 22 individuals with primary infection (PHI) stage 23 HIV-negative normal control (NC) subjects. CD4+ T...
Natural killer (NK) cells are important for maintenance of innate immune system stability and serve as a first line defense against tumors virus infections; they can act either directly or indirectly regulated via co-operation between inhibitory stimulatory surface receptors. The recently reported receptor, TIGIT, be expressed on the NK cell surface; however, expression level function TIGIT during HIV infection is unknown. In this study, time, we investigated in from HIV-infected...
While traditional epidemiological studies are of great interest in describing the dynamics epidemics, they struggle to fully capture geospatial and factors driving dispersal pathogens like HIV as have difficulties capturing linkages between infections. To overcome this, we used a discrete phylogeographic approach coupled generalized linear model extension characterize drivers across-province spread five main types circulating China. Our results indicate that large urbanized areas with dense...
As HIV-1 continues to spread in China from traditional high risk populations the general public, its genetic makeup has become increasingly complex. However, impact of these changes on biological and neutralization sensitivity virus is unknown. The current study aims characterize genetic, biological, identified between 2004 2007. Based a total 107 full-length envelope genes obtained directly infected patients, we found that those viruses fell into three major groups: CRF01_AE, subtype B',...
Natural killer (NK) cells play cytotoxic roles by targeting tumor or virus infected cells, they also regulatory secreting cytokines and chemokines. Transforming growth factor (TGF)-β interleukin (IL)-10 are important immunosuppressive potentially related to the immune dysregulation that occurs in infection of human immunodeficiency (HIV). NK an source TGF-β a main early producer IL-10 response viral infection. Here, we evaluated percentages IL-10+ TGF-β+ HIV-infected patients relative...
Abstract As the most dominant HIV-1 strain in China, CRF01_AE needs to have its evolutionary and demographic history documented. In this study, we provide phylogenetic analysis of all pol sequences identified mainland China. were collected from Los Alamos HIV Sequence Database local Chinese provincial centers disease control prevention. Phylogenetic trees constructed identify major epidemic clusters. Bayesian coalescent-based method was used reconstruct time scale history. There 2965 24...
Abstract Background Chemokines are small chemotactic cytokines involved in inflammation, cell migration, and immune regulation both physiological pathological contexts. Here, we investigated the profile of chemokines during primary HIV infection (PHI). Methods Fifty-four participants with blood samples before clinical information available were selected from an HIV-negative man who have sex men (MSM) prospective cohort. Thirty 10 measured pre- post-HIV same individuals using a Bio-Plex Pro™...
Since the implementation of "treat all" policy in China 2016, there have been few data on prevalence transmitted drug resistance (TDR) China. In this study, we describe TDR patients newly diagnosed with human immunodeficiency virus (HIV) infection between 2016 and 2019 Shenyang city, Demographic information plasma samples from all reported HIV-infected individuals to were collected. The HIV pol gene was amplified sequenced for subtyping TDR. spread analyzed by inferring an molecular network...
Vaccination reduces the incidence of severe COVID-19 and death effectively limits viral spread. Concerns have been raised about vaccine responses in large population HIV-infected patients. This study aims to explore safety immunogenicity inactivated people living with HIV (PLWH).All participants this already had their second dose an at least 14 days earlier, without a history SARS-CoV-2 infection. The primary outcomes were adverse reactions changes CD4+ T-cell counts. IgG neutralizing...
Natural killer (NK) cells are crucial for immune responses to viral infections. CD160 is an important NK cell activating receptor, with unknown function in HIV infection. Here, we found that expression was reduced on from HIV-infected individuals and its negatively correlated disease progression. Further, GLUT1 glucose uptake were higher CD160+ cells, the results of RNA-seq flow cytometry demonstrated positively regulated metabolism through PI3K/AKT/mTOR/s6k signaling pathway, thereby...
To elucidate the recent changes in prevalence of HIV-1 primary resistance mutations men who have sex with (MSM) Liaoning province, 217 samples from antiretroviral therapy-naive MSM were collected. For 201 samples, entire protease gene and 256 amino acids reverse transcriptase successfully amplified by polymerase chain reaction (RT-PCR) nested PCR viral RNA sequenced. Among pol sequences, CRF01_AE accounted for 87.6% (176/201), subtype B 8.0% (16/201), CRF07_BC 4.5% (9/201). The overall...
CD3 + CD56 NKT-like cells are one of the critical effectors in immune response to viral infection and tumors, but functional features HIV have been rarely reported. In this study, we observed described state cell functions primary HIV-infected individuals (PHIs), chronic (CHIs), long-term nonprogressors (LTNPs), HIV-negative controls (NCs). The results showed that percentage IFN- γ was notably higher LTNPs compared with CHIs, proportion dual function (IFN- CD107a cells) also much than CHIs....
A major barrier to HIV eradication is the persistence of viral reservoirs. Resting CD4 + T cells are thought be one reservoirs, However, underlying mechanism regulating infection and establishment reservoir in remain poorly understood. We have investigated role IP-10 reservoirs cells, found that HIV-infected individuals, plasma was elevated, positively correlated with load size. In addition, we binding CXCR3 enhanced latent resting vitro. Mechanistically, stimulation promoted cofilin...
We report here a novel HIV-1 circulating recombinant form (CRF) (CRF59_01B) comprised of CRF01_AE and subtype B, with two recombination breakpoints in the pol vpu-env regions, respectively. CRF59_01B was identified from three epidemiologically unlinked men who have sex (MSM) northeast China. This represents second CRF MSM population
Yunnan has the largest number of reported HIV/AIDS cases among all Chinese provinces, prevalence HIV men who have sex with (MSM) passed 10%, while incidence epidemic and molecular characteristics new infected MSM were not evaluated before.An 18 months prospective followed up a frequency 3 month per visit conducted seronegative in Kunming cityduring 2009-2011. Interviewer-administrated questionnaires carried out. Blood specimens obtained to test for syphilis HIV, which by standard enzyme...
The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China. A large-scale national survey we conducted on strains MSM 11 provinces China from 2008 2013 (n = 920) identified a novel transmission cluster consisting of six (0.7%) that belonged new circulating recombinant form (designated CRF59_01B). CRF59_01B contains two subtype B segments U.S.-European origin (in the pol and vpu-env regions) CRF01_AE backbone. is second CRF (after CRF55_01B) primarily occurs at low...