A5001341467- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Advanced Glycation End Products research
- Machine Learning in Bioinformatics
- Advanced Proteomics Techniques and Applications
- Kruppel-like factors research
- Cytokine Signaling Pathways and Interactions
- Gene expression and cancer classification
- Vasculitis and related conditions
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
China Medical University
2017-2024
First Hospital of China Medical University
2018-2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2019
National Health and Family Planning Commission
2017-2018
Natural killer (NK) cells are the first line of defense against pathogens immune system and also play an important role in resistance HIV. The activating receptor NKG2C inhibitory NKG2A co-modulate function NK by recognizing same ligand, HLA-E. However, on viral set point prediction HIV disease progression have been rarely reported. In this study, we determined expression or surface from 22 individuals with primary infection (PHI) stage 23 HIV-negative normal control (NC) subjects. CD4+ T...
Natural killer (NK) cells are important for maintenance of innate immune system stability and serve as a first line defense against tumors virus infections; they can act either directly or indirectly regulated via co-operation between inhibitory stimulatory surface receptors. The recently reported receptor, TIGIT, be expressed on the NK cell surface; however, expression level function TIGIT during HIV infection is unknown. In this study, time, we investigated in from HIV-infected...
Natural killer (NK) cells play cytotoxic roles by targeting tumor or virus infected cells, they also regulatory secreting cytokines and chemokines. Transforming growth factor (TGF)-β interleukin (IL)-10 are important immunosuppressive potentially related to the immune dysregulation that occurs in infection of human immunodeficiency (HIV). NK an source TGF-β a main early producer IL-10 response viral infection. Here, we evaluated percentages IL-10+ TGF-β+ HIV-infected patients relative...
Abstract Background Chemokines are small chemotactic cytokines involved in inflammation, cell migration, and immune regulation both physiological pathological contexts. Here, we investigated the profile of chemokines during primary HIV infection (PHI). Methods Fifty-four participants with blood samples before clinical information available were selected from an HIV-negative man who have sex men (MSM) prospective cohort. Thirty 10 measured pre- post-HIV same individuals using a Bio-Plex Pro™...
A major barrier to HIV eradication is the persistence of viral reservoirs. Resting CD4 + T cells are thought be one reservoirs, However, underlying mechanism regulating infection and establishment reservoir in remain poorly understood. We have investigated role IP-10 reservoirs cells, found that HIV-infected individuals, plasma was elevated, positively correlated with load size. In addition, we binding CXCR3 enhanced latent resting vitro. Mechanistically, stimulation promoted cofilin...
Abstract As the first line of defense in human immune system, NK cells play essential roles prevention tumorigenesis and viral infection. It is known that have impaired function HIV infection; however, it remains unclear why this occurs. IP-10 a chemokine inflammatory factor associated with such diseases as tuberculosis, hepatitis B virus, pancreatic cancer. The aim study was to evaluate levels CXCR3 expression were affected by elucidate whether cell could be IP-10. Our results demonstrate...
Abstract Autophagy activation protects against podocyte injury in idiopathic membranous nephropathy (IMN). The AMPK/mTOR signaling pathway is a vital autophagy regulatory pathway. Metformin promotes autophagy, whereas rapamycin an agonist. However, the therapeutic mechanisms of metformin and IMN remain unclear. Thus, we examined action by regulating Female Sprague–Dawley (SD) rats were treated with cationic bovine serum albumin (C-BSA) to establish model randomly divided into model,...
Abstract The percentage of human CD56−CD16+ NK cells increases during chronic infection with HIV; however, the biologic role in HIV is unclear. Our results demonstrate that producing IL-10 and TGF-β was higher than CD56dimCD16+ cells. could inhibit IFN-γ production by autologous CD8+ T cells, this inhibition be partially reversed anti-IL-10, anti-TGF-β, or anti-PD-L1 mAbs. are potential targets for development novel immune therapies against infection.
Background: Autophagy activation protects against podocyte injury in idiopathic membranous nephropathy (IMN). The AMPK/mTOR signaling pathway is a vital autophagy regulatory pathway. Metformin promotes autophagy, whereas rapamycin an agonist. However, the therapeutic mechanisms of metformin and MN remain unclear. Thus, we examined action by regulating pathway.Methods: Female Sprague-Dawley (SD) rats were treated with cationic bovine serum albumin (C-BSA) to establish model randomly divided...