A5031414863- GDF15 and Related Biomarkers
- Kruppel-like factors research
- Genomics, phytochemicals, and oxidative stress
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Inflammatory mediators and NSAID effects
- Phytochemicals and Antioxidant Activities
- Macrophage Migration Inhibitory Factor
- Adipose Tissue and Metabolism
- Plant biochemistry and biosynthesis
- Cancer, Lipids, and Metabolism
- Pharmacological Effects of Natural Compounds
- Wnt/β-catenin signaling in development and cancer
- Tannin, Tannase and Anticancer Activities
- Cancer-related gene regulation
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
- Pancreatic function and diabetes
- Tea Polyphenols and Effects
- Natural product bioactivities and synthesis
- Circular RNAs in diseases
- Bioactive Compounds and Antitumor Agents
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Natural Antidiabetic Agents Studies
University of Maryland, College Park
2015-2024
Park University
2020
Kangdong Sacred Heart Hospital
2019
Hallym University
2019
Busan TechnoPark
2017
University of Tennessee at Knoxville
2005-2016
Northwest A&F University
2013
National Institute of Environmental Health Sciences
2009-2011
Knoxville College
2011
The University of Texas MD Anderson Cancer Center
2009
Abstract 6‐Gingerol, a natural product of ginger, has been known to possess anti‐tumorigenic and pro‐apoptotic activities. However, the mechanisms by which it prevents cancer are not well understood in human colorectal cancer. Cyclin D1 is proto‐oncogene that overexpressed many cancers plays role cell proliferation through activation β‐catenin signaling. Nonsteroidal anti‐inflammatory drug (NSAID)‐activated gene‐1 (NAG‐1) cytokine associated with properties. In present study, we examined...
We have shown previously that mice with a targeted disruption in the stearoyl-CoA desaturase 1 gene ( SCD1 -/- ) increased insulin sensitivity compared control mice. Here we show signaling muscle. The basal tyrosine phosphorylation of receptor and substrates 2 are elevated. insulin-like growth factor-1 was similar between +/+ association αp85 subunit phosphatidylinositol 3-kinase as well Akt-Ser-473 Akt-Thr-308 also elevated Interestingly, mRNA levels, protein mass, activity protein-tyrosine...
There is persuasive epidemiological and experimental evidence that dietary polyphenolic plant-derived compounds have anticancer activity. Many laboratories, including ours, reported such an effect in cancers of the gastrointestinal tract, lung, skin, prostate breast. The catechins are a group polyphenols found green tea, which one most commonly consumed beverages world. While preponderance data strongly indicates significant antitumorigenic benefits from tea catechins, potential molecular...
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to chemopreventive activity, but the mechanisms involved are not clearly understood. Although NSAIDs inhibit cyclooxygenase they also increase expression of a divergent member transforming growth factor-β superfamily, termed NSAID-activated gene 1 (NAG-1), protein with an antitumorigenic and proapoptotic activity that could in part be linked chemoprevention NSAIDs. NAG-1 is induced by some NSAIDs, responsible clear. In this...
Stearoyl-CoA desaturase (SCD) has recently been shown to be a critical control point of lipid partitioning and body weight regulation. Lack SCD1 function significantly increases insulin sensitivity in skeletal muscles corrects the hypometabolic phenotype leptin-deficient ob/ ob mice, indicating direct antilipotoxic action deficiency. The mechanism underlying metabolic effects mutation is currently unknown. Here we show that deficiency reduced total ceramide content oxidative (soleus red...
Stearoyl-CoA desaturase (SCD) is a microsomal enzyme involved in the biosynthesis of oleate and palmitoleate. Mice with targeted disruption SCD1 isoform (SCD1-/-) exhibit reduced adiposity increased energy expenditure. To address whether expenditure attributable to thermogenesis, we investigated effect deficiency on basal cold-induced thermogenesis. SCD1-/- mice have expression uncoupling proteins brown adipose tissue (BAT) relative controls. The beta3-adrenergic receptor (beta3-AR) was...
Conjugated linoleic acids (CLAs), naturally occurring fatty in ruminant food products, have anti-tumorigenic and pro-apoptotic properties animal as well vitro models of cancer. However, the cellular mechanism has not been fully understood. NAG-1 (non-steroidal anti-inflammatory drug-activated gene-1) is induced by several dietary compounds belongs to a TGF-β superfamily gene associated with activities. The present study was performed elucidate molecular which CLA stimulates activity human...
Cancer is a leading cause of morbidity and mortality worldwide. A promising area cancer research focused on chemoprevention by nutritional compounds. Epidemiological studies have shown strong negative correlation between fruit, vegetable, spice intake rates cancer. Although individual active compounds demonstrated significant anticancer activity, an emerging focusing the combination multiple dietary that act synergistically to exert greater effects. The current study evaluated potential...
Stearoyl-CoA desaturase catalyzes the rate-limiting step in biosynthesis of monounsaturated fatty acids, which are required for normal rates synthesis triglycerides, cholesterol esters, and phospholipids. Mice with a targeted disruption stearoyl-CoA 1 (SCD1) isoform protected against diet leptin deficiency-induced adiposity, have increased energy expenditure, up-regulated expression hepatic genes encoding enzymes acid beta-oxidation. Because peroxisome proliferator-activated receptor-alpha...
The signaling pathway of phosphatidylinositol 3-kinase (PI3K)/AKT, which is involved in cell survival, proliferation, and growth, has become a major focus targeting cancer therapeutics. Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) was previously identified as induced by several anti-tumorigenic compounds including nonsteroidal drugs, peroxisome proliferator-activated receptor gamma ligands, dietary compounds. NAG-1 been shown to exhibit and/or pro-apoptotic activities vivo...