A5045270589- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Genetics, Aging, and Longevity in Model Organisms
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Cholesterol and Lipid Metabolism
- Pesticide Exposure and Toxicity
- Diet and metabolism studies
- Insect and Pesticide Research
- Birth, Development, and Health
- Per- and polyfluoroalkyl substances research
- Natural Products and Biological Research
- Neurobiology and Insect Physiology Research
- Biochemical Acid Research Studies
- Sirtuins and Resveratrol in Medicine
- Proteins in Food Systems
- Potato Plant Research
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
- Diet, Metabolism, and Disease
- Research in Cotton Cultivation
- Liver Disease Diagnosis and Treatment
University of Massachusetts Amherst
2016-2025
Kyung Hee University
2014-2020
Chung-Ang University
2020
Amherst College
2019
Sacred Heart Hospital
2018
Weatherford College
2015-2016
University of Maryland, College Park
2015
University of Massachusetts Boston
2013
Dankook University
2010
University of Wisconsin–Madison
1997-2006
Abstract The effects of conjugated linoleic acid (CLA) on body composition were investigated. ICR mice fed a control diet containing 5.5% corn oil or CLA‐supplemented (5.0% plus 0.5% CLA). Mice exhibited 57% and 60% lower fat 5% 14% increased lean mass relative to controls ( P <0.05). Total carnitine palmitoyltransferase activity was by dietary CLA supplementation in both pad skeletal muscle; the differences significant for muscle fasted mice. In cultured 3T3‐L1 adipocytes treatment (1×10...
Abstract We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for cis ‐9, trans ‐11 CLA isomer or ‐10, ‐12 isomer, on body composition in mice. Body changes (reduced fat, enhanced water, protein, and ash) associated with feeding isomer. In cultured 3T3‐L1 adipocytes, reduced lipoprotein lipase activity, intracellular triacylglycerol glycerol, glycerol release into medium. By contrast, isomers did not affect these biochemical activities. conclude...
Abstract Two experiments were conducted. In Experiment 1, 8‐wk‐old mice fed control diet or supplemented with 0.5% conjugated linoleic acid (CLA) to study the effect of CLA on body composition (CLA: 40.8–41.1% c ‐9, t ‐11 isomer, 43.5–44.9% ‐10, ‐12 isomer). The data for CLA‐fed vs. controls described parallel but significantly distinct responses both absolute and relative changes in fat mass (reduced mice) whole protein water (both which increased mice). mice, appeared precede reduction...
Imidacloprid, a neonicotinoid insecticide widely used in agriculture worldwide, has been reported to promote adipogenesis and cause insulin resistance vitro. The purpose of the current study was determine effects imidacloprid its interaction with dietary fat development adiposity using male C57BL/6J mice. Imidacloprid (0.06, 0.6, or 6 mg/kg bw/day) mixed low-fat (4% w/w) high-fat (20% diet given mice ad libitum for 12 weeks. significantly promoted high diet-induced body weight gain...
Four different methods for methylating conjugated linoleic acid (CLA) were compared. The HCl/MeOH and BF3/MeOH tested under time temperature combinations. Increasing and/or incubation either method decreased the cis-9,trans-11 trans-10,cis-12 isomers, but trans-9,trans-11/trans-10,trans-12 isomers artifacts (allylic methoxide) increased. In addition, triacylglyceride form of CLA was using above NaOMe at various temperatures 20 min. did not generate methoxy artifacts. However, there...
Conjugated linoleic acids (CLAs), naturally occurring fatty in ruminant food products, have anti-tumorigenic and pro-apoptotic properties animal as well vitro models of cancer. However, the cellular mechanism has not been fully understood. NAG-1 (non-steroidal anti-inflammatory drug-activated gene-1) is induced by several dietary compounds belongs to a TGF-β superfamily gene associated with activities. The present study was performed elucidate molecular which CLA stimulates activity human...
There is emerging evidence that organochlorine and organophosphorus insecticide exposure may be linked to excessive weight gain symptoms of diabetes. However, there a lack knowledge for other types insecticides with potential influence on obesity Thus, the purpose this investigation was determine role imidacloprid, neonicotinoid insecticide, in lipid metabolism by use 3T3-L1 adipocytes. Imidacloprid treatment potentiated accumulation adipocytes significantly increased expression key...
Significance Obesity is associated with enhanced colonic inflammation, which a major risk factor for colorectal cancer. To date, the mechanisms by obesity increases inflammation are not well-understood, and there few effective strategies controlling obesity-induced diseases. Here, using LC-MS/MS–based metabolomics, we report that soluble epoxide hydrolase (sEH) could be novel therapeutic target inflammation. This lead to rapid human translation, as pharmacological inhibitors of sEH being...