A5101433908- Multiple Myeloma Research and Treatments
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Chemokine receptors and signaling
- Bone Metabolism and Diseases
- Cancer Mechanisms and Therapy
- Chronic Lymphocytic Leukemia Research
- Histone Deacetylase Inhibitors Research
- HIV/AIDS drug development and treatment
- Protein Degradation and Inhibitors
- Monoclonal and Polyclonal Antibodies Research
- Blood groups and transfusion
- Ubiquitin and proteasome pathways
- Emergency and Acute Care Studies
- Herpesvirus Infections and Treatments
- Quinazolinone synthesis and applications
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- Inflammatory mediators and NSAID effects
- HER2/EGFR in Cancer Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Risks and Factors
- Multiple and Secondary Primary Cancers
- Protease and Inhibitor Mechanisms
National Center for Health Statistics
2023
Division of Cancer Epidemiology and Genetics
2017-2021
National Cancer Institute
2017-2021
Harvard University
2007-2016
Massachusetts General Hospital
2010-2016
Dana-Farber Cancer Institute
2007-2010
University of Turin
2006-2007
Azienda Ospedaliero Universitaria San Giovanni Battista
2004-2006
Istituto di Ematologia di Bologna
2004
PURPOSE We investigated the effect on minimal residual disease, by qualitative and real-time quantitative polymerase chain reaction (RQ-PCR), of a consolidation regimen that included bortezomib, thalidomide, dexamethasone (VTD) in patients with multiple myeloma (MM) responding to autologous stem-cell transplantation (auto-SCT). PATIENTS AND METHODS Patients achieving at least very good partial response who had an available molecular marker based immunoglobulin heavy-chain rearrangement...
ABSTRACT Sclerostin is a potent inhibitor of osteoblastogenesis. Interestingly, newly diagnosed multiple myeloma (MM) patients have high levels circulating sclerostin that correlate with disease stage and fractures. However, the source impact in MM remains to be defined. Our goal was determine role biology its bone microenvironment as well investigate effect targeting neutralizing antibody (scl-Ab) disease. Here we confirm increased compared precursor states like monoclonal gammopathy...
Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). Risk models that estimate the risk progression from MGUS to multiple use data a single time point, usually initial workup.
Abstract We assessed mpox virus prevalence in blood, pharyngeal, and rectal specimens among persons without characteristic rash presenting for JYNNEOS vaccine. Our data indicate that the utility of risk-based screening skin lesions or via pharyngeal swabs, and/or blood is likely limited.
Pan proviral integrations of Moloney virus (PIM) inhibition in multiple myeloma (MM) results reduced cell viability tested human-derived MM lines and reduces tumor burden xenograft mouse models, making PIMs important therapeutic targets for the disease. PIM kinase inhibitors are currently being clinically MM. We sought to elucidate role various Our data demonstrate that Pim2 has a significant cytotoxicity. provide evidence novel regulation DNA damage response (DDR). Knockdown upregulates...
Resistin is a polypeptide hormone secreted by adipose tissue. A prior hospital-based case–control study reported serum resistin levels to be inversely associated with risk of multiple myeloma (MM). To date, this association has not been investigated prospectively. We measured concentrations for pre-diagnosis peripheral blood samples from 178 MM cases and 358 individually matched controls three cohorts participating in the cohort consortium. In overall analyses, higher were weakly reduced...
Abstract Background Experimental and clinical studies have implicated certain chemokines angiogenic cytokines in multiple myeloma (MM) pathogenesis. To investigate whether systemic concentrations of these markers are associated with future MM risk progression from its precursor, monoclonal gammopathy undetermined significance (MGUS), we conducted a prospective study within the Prostate, Lung, Colorectal Ovarian Cancer Screening Trial. Methods We measured 45 immunologic pro-angiogenic sera...
The epidemiologic evidence regarding the relationship between alcohol consumption and multiple myeloma (MM) risk remains limited inconsistent, although recent studies suggest a potential protective effect. We prospectively investigated of MM in relation to frequency among 499,292 participants enrolled National Institutes Health (NIH)‐AARP Diet Study 1995–1996. A total 1,312 cases were identified during follow‐up through December 2011. Hazard ratios (HR) 95% confidence intervals (CI) for...
14602 Background: Cyclin-dependent kinases (Cdk) regulate the cell cycle through interaction with various cyclins. Uncontrolled proliferation of cancer cells is predominantly a consequence dysregulation Cdks and/or their cyclin complexes as well inhibitors. Targeting Cdk therefore promising therapeutic strategy, and small molecule inhibitors have been developed. These agents are currently being studied in tumor types. Deregulation cyclins, specifically D multiple myeloma (MM) characterized,...