A5039730752- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Genomics and Phylogenetic Studies
- SARS-CoV-2 detection and testing
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Education and Digital Technologies
- Protein Structure and Dynamics
- COVID-19 diagnosis using AI
- Virology and Viral Diseases
- Microbial Metabolic Engineering and Bioproduction
- Computational Drug Discovery Methods
- Machine Learning in Bioinformatics
- Immune responses and vaccinations
- Bacillus and Francisella bacterial research
- Software Engineering Research
- Science and Education Research
- Viral Infections and Outbreaks Research
- Academic Research in Diverse Fields
- Online Learning and Analytics
- COVID-19 Digital Contact Tracing
- RNA and protein synthesis mechanisms
- Fractal and DNA sequence analysis
- Gene expression and cancer classification
- Child Development and Digital Technology
Universidade Federal dos Vales do Jequitinhonha e Mucuri
2019-2025
Universidade Federal de Minas Gerais
2020-2024
Stellenbosch University
2022-2024
Fundação Oswaldo Cruz
2019-2024
Instituto de Ciencias Agrarias
2020-2024
University of KwaZulu-Natal
2023
Universidade Federal de Uberlândia
2014
Highlights•Global phylogenetic analysis reveals dispersal of VOCs along worldwide flight network•Omicron spread to five times more countries within 100 days emergence than other VOCs•Delta and Omicron dispersed from secondary hubs during accelerating air travel•Highly connected were major global regional exporters VOCsSummaryThe Alpha, Beta, Gamma SARS-CoV-2 variants concern (VOCs) co-circulated globally 2020 2021, fueling waves infections. They displaced by Delta a third wave in which,...
Abstract Proteins are intricate, dynamic structures, and small changes in their amino acid sequences can lead to large effects on folding, stability dynamics. To facilitate the further development evaluation of methods predict these changes, we have developed ThermoMutDB, a manually curated database containing >14,669 experimental data thermodynamic parameters for wild type mutant proteins. This represents an increase 83% unique mutations over previous databases includes information...
The dengue virus poses a major global health threat, with nearly 390 million infections annually. A recently proposed hierarchical nomenclature system enhances spatial resolution by defining and minor lineages within genotypes, aiding efforts to track viral evolution. While current subtyping tools - Genome Detective, GLUE, NextClade rely on computationally intensive sequence alignment phylogenetic inference, machine learning presents promising alternative for achieving accurate rapid...
The rapid increase in nucleotide sequence data generated by next-generation sequencing (NGS) technologies demands efficient computational tools for comparison. Alignment-free (AF) methods offer a scalable alternative to traditional alignment-based approaches such as BLAST. This study evaluates alignment-free and alternatives viral classification, focusing on identifying techniques that maintain high accuracy efficiency when applied extremely large datasets. We employed six established AF...
EasyVS is a web-based platform built to simplify molecule library selection and virtual screening. With an intuitive interface, the tool allows users go from selecting protein target with known structure tailoring purchasable performing visualizing docking in few clicks. Our system also filter screening libraries based on properties, cluster molecules by similarity personalize parameters.EasyVS freely available as easy-to-use web interface at...
Mozambique reported the first case of coronavirus disease 2019 (COVID-19) in March 2020 and it has since spread to all provinces country. To investigate introductions SARS-CoV-2 Mozambique, 1 142 whole genome sequences sampled within were phylogenetically analyzed against a globally representative set, reflecting 25 months epidemic. The epidemic country was marked by four waves infection, associated with B.1 ancestral lineages, while Beta, Delta, Omicron Variants Concern (VOCs) responsible...
In many regions of the world, Alpha, Beta and Gamma SARS-CoV-2 Variants Concern (VOCs) co-circulated during 2020-21 fueled waves infections. During 2021, these variants were almost completely displaced by Delta variant, causing a third wave infections worldwide. This phenomenon global viral lineage displacement was observed again in late when Omicron variant disseminated globally. this study, we use phylogenetic phylogeographic methods to reconstruct dispersal patterns VOCs We find that...
Abstract The rate of biological data generation has increased dramatically in recent years, which driven the importance databases as a resource to guide innovation and insights. Given complexity scale these databases, automatic classification is often required. Biological sets are hierarchical nature, with varying degrees complexity, imposing different challenges train, test validate accurate generalizable models. While some approaches classify have been proposed, no guidelines regarding...
In the present investigation, we employ a novel and meticulously structured database assembled by experts, encompassing macrofungi field-collected in Brazil, featuring upwards of 13,894 photographs representing 505 distinct species. The purpose utilizing this is twofold: firstly, to furnish training validation for convolutional neural networks (CNNs) with capacity autonomous identification macrofungal species; secondly, develop sophisticated mobile application replete an advanced user...
Abstract Background The rapid increase in nucleotide sequence data generated by next-generation sequencing (NGS) technologies demands efficient computational tools for comparison. Alignment-based methods, such as BLAST, are increasingly overwhelmed the scale of contemporary datasets due to their high classification. This study evaluates alignment-free (AF) methods scalable and alternatives viral classification, focusing on identifying techniques that maintain accuracy efficiency when applied...
In this paper, we present the findings of a systematic review SRE literature, covering 300 papers in 95 publication venues (conferences and journals) last twelve years. We employ statistic techniques to help mining patterns trends from analyzed data set. identified prevalence purely theoretical studies surveyed period, where no more than 31% are experimental research. Also, number research works "Reliability Assessment" has clearly increased since 2002, especially during three On other hand,...
The INFORM-Africa Consortium, a research hub of the NIH-funded DS-I Africa, will leverage Data Management and Analysis Core (DMAC) Next Generation Sequencing (NGS) to ensure effective data management analysis.The DMAC capture analyse data, making it accessible collaborators across multiple African countries future hubs.The aim is increase access high-quality, reproducible that can be used engage policymakers better prepare for pandemics, while also removing barriers sharing integration...
In Angola, COVID-19 cases have been reported in all provinces, resulting >105,000 and >1900 deaths. However, no detailed genomic surveillance into the introduction spread of SARS-CoV-2 virus has conducted Angola. We aimed to investigate emergence epidemic progression during peak pandemic
A disparidade de gênero é evidente em áreas como a tecnologia. Para enfrentar esse desafio, surgiu o projeto Código X, que promove empoderamento e inclusão digital entre meninas 9 14 anos. Inicialmente com aulas presenciais, se adaptou à pandemia 'Código X Casa' 'Trilha Online'. Em 2022, foram introduzidas novas etapas, 'Maratona Tech', seguida pela 'Pré-Trilha' 2023. Formalmente estabelecido ONG 2023, está desenvolvendo material para replicar sua metodologia, visando ampliar interesse das...
Brazil, Russia, India, China, and South Africa (BRICS) are a group of developing countries with shared economic, healthcare, scientific interests. These navigate multiple syndemics, the COVID-19 pandemic placed severe strain on already burdened BRICS’ healthcare systems, hampering effective interventions. Genomic surveillance molecular epidemiology remain indispensable tools for facilitating informed intervention. To evaluate combined manner in which unfolded BRICS countries, we reviewed...
Diante da evidente desigualdade de gênero, principalmente nas áreas relacionadas à tecnologia, o projeto Código X busca proporcionar a meninas, que cursaram ensino fundamental e vivem em regiões vulnerabilidade social, um contato com atividades fora sua realidade. Durante período isolamento novos desafios surgem para minimizar as desigualdades, estimulando desenvolvimento novas metodologias. Assim nasceu casa, criando uma forma distância lógica programação. A metodologia é baseada Pensamento...
Bioinformatics is a fast-evolving research field, requiring effective educational initiatives to bring computational knowledge Life Sciences. Since 2017, an organizing committee composed of graduate students and postdoctoral researchers from the Universidade Federal de Minas Gerais (Brazil) promotes week-long event named Summer Course in (CVBioinfo). This aims diffuse bioinformatic principles, news, methods mainly focused on audiences undergraduate students. Furthermore, as advent COVID-19...
Background: In Angola, COVID-19 cases have been reported in all provinces, resulting >105,000 and >1,900 deaths. However, no detailed genomic surveillance into the introduction spread of SARS-CoV-2 virus has conducted Angola. We aimed to investigate emergence, epidemic progression during peak pandemic Methods: generated 1,210 whole-genome sequences, contributing West African data global context, that were phylogenetically compared against strains. Viral movement events inferred using...