A5046217417- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Machine Learning in Bioinformatics
- vaccines and immunoinformatics approaches
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Genetics and Biotechnology
- Calibration and Measurement Techniques
- Heat shock proteins research
- Immune cells in cancer
- Antibiotic Resistance in Bacteria
- Advanced Semiconductor Detectors and Materials
- Satellite Image Processing and Photogrammetry
- Protein Structure and Dynamics
- Tuberculosis Research and Epidemiology
- RNA modifications and cancer
- Enzyme Structure and Function
- Genomics and Rare Diseases
- Phase-change materials and chalcogenides
- Pharmacological Receptor Mechanisms and Effects
- Infrared Target Detection Methodologies
- Medicinal Plants and Neuroprotection
- Advanced Thermoelectric Materials and Devices
- Pregnancy and Medication Impact
- Bacterial biofilms and quorum sensing
University of Delhi
1984-2025
Mercy Hospital for Women
2024
The University of Melbourne
2020-2024
Washington University in St. Louis
2023-2024
Florey Institute of Neuroscience and Mental Health
2022
Baker Heart and Diabetes Institute
2020
Australian Cancer Research Foundation
2020
National Institute of Construction Management and Research
2010
Indian Space Research Organisation
2008
Abstract Recent evidences suggest that the localization of mRNAs near subcellular compartment translated proteins is a more robust cellular tool, which optimizes protein expression, post-transcriptionally. Retention mRNA in nucleus can regulate amount from each mRNA, thus allowing tight temporal regulation translation or buffering levels bursty transcription. Besides, performs variety additional roles like long-distance signaling, facilitating assembly complexes and coordination...
Abstract Peptides are attractive alternatives for the development of new therapeutic strategies due to their versatility and low complexity synthesis. Increasing interest in these molecules has led creation large collections experimentally characterized peptides, which greatly contributes data‐driven computational approaches. Here we propose CSM‐peptides, a novel machine learning method rapid identification eight different types peptides: anti‐angiogenic, anti‐bacterial, anti‐cancer,...
Genetic variation in voltage-gated sodium (NaV) channels is a significant contributor to neurodevelopmental disorders. NaV channel alpha subunits are encoded by the SCNxA family and four predominately expressed brain: SCN1A, SCN2A, SCN3A, SCN8A. Gene expression developmentally regulated, they known express functionally distinct transcript variants. Precision therapies targeting these genes their variants currently preclinical development, yet developmental of transcripts human brain be fully...
The emergence and spread of carbapenem-resistant Klebsiella pneumoniae infections have worsened the current situation worldwide, in which totally drug-resistant strains (bad bugs) are becoming increasingly prominent. Bacterial biofilms enable bacteria to tolerate higher doses antibiotics other stresses, may lead drug resistance. In present study, we performed proteomics on NDM-4-producing K. clinical isolate under meropenem stress. Liquid chromatography coupled with mass spectrometry...
Autoimmune diseases emerge due to several reasons, of which molecular mimicry i.e. similarity between the host's and pathogen's interacting peptides is an important reason. In present study we have reported a database only experimentally verified peptide sequences, exhibit mimicry. The named as miPepBase (Mimicry Peptide Database) contains comprehensive information about proteins both host (and model organism) pathogen. It also provides physicochemical properties protein peptides, might be...
Abstract Yersinia pseudotuberculosis is one of the three pathogenic species genus . Most studies regarding pathogenesis Y. are based on proteins related to Type III secretion system, which a well-known primary virulence factor in Gram-negative bacteria, including Information factors involved granuloma formation scarce. In present study we have used computational approach identify that might be potentially granuloma. A comparative proteome analysis and conserved orthologous protein...
Microbial mimicry of the host proteins/peptides can elicit auto-reactive T- or B-cells resulting in autoimmune disease(s). Since intrinsically disordered protein regions (IDPRs) are involved several cell signaling and PPI networks, molecular IDPRs help pathogens substituting their own proteins cell-signaling networks and, ultimately hijacking cellular machinery. Thus, present study was conducted to discern structural disorder like, recognition features (MoRFs), short linear motifs (SLiMs),...
Gut virome plays an important role in human physiology but remains poorly understood. This study reports investigation of the gut DNA-virome a previously unexplored ethnic population through metagenomics faecal samples collected from individuals residing Northern India. Analysis shows that, similar to populations investigated earlier, majority identified belongs bacteriophages and smaller fraction (<20 %) consists viruses that infect animals, archaea, protists, multiple domains or plants....
Mycobacterium avium subspecies paratuberculosis (MAP) exhibits 'molecular mimicry' with the human host resulting in several autoimmune diseases such as multiple sclerosis, type 1 diabetes mellitus (T1DM), Hashimoto's thyroiditis, Crohn's disease (CD), etc. The conventional therapy for includes immunosuppressants or immunomodulators that treat symptoms rather than etiology and/or causative mechanism(s). Eliminating MAP-the etiopathological agent might be a better strategy to MAP-associated...
Nascent polypeptide-associated complex (NAC) is a ribosome-associated molecular chaperone which present only in archaea and eukaryotes. The primary function of NAC to shield the newly synthesized polypeptide chains from inappropriate interactions with cytosolic factors. Besides, has been implicated diverse biological functions suggest that it might be multifunctional protein. An elaborate study on can provide useful information protein folding extreme conditions many grow. Thus, study, we...
Secretory proteins are important for microbial adaptation and survival in a particular environment. Till date, experimental secretomes have been reported few archaea. In this study, we identified the secretome of Picrophilous torridus evaluated efficacy various signal peptide predictors (SPPs) identifying peptides (SPs) its secretome. Liquid chromatography mass spectrometric (LC MS) analysis was performed three independent P . samples only those which were common experiments selected further...
In brief Preterm birth is the leading cause of perinatal morbidity and mortality, new therapies that delay preterm improve neonatal outcomes are urgently needed. This study investigates whether ticagrelor inhibits uterine contractility inflammation in preclinical vitro , ex vivo (human) (mouse) studies, to explore potential repurposing for prevention birth. Abstract remains a significant global health challenge, affecting approximately 10% pregnancies resulting one million deaths globally...
ABSTRACT Metagenomics has revealed an unprecedented viral diversity in human gut although, most of the sequence data remains to be characterized. In this study, we mined a collection 1090 metagenome assembled “high quality” genomes viruses. Sequence analysis eight new species from seven genera class, Caudoviricetes and nineteen fourteen ssDNA virus family, Microviridae. addition, four were identified, which do not show similarity sequences present any major databases, NCBI RefSeq, IMG-VR,...
<title>Abstract</title> Background Substantial evidence has established the critical role of microglia, brain's resident immune cells, in pathogenesis Alzheimer's disease (AD). Microglia exhibit diverse transcriptional states response to neuroinflammatory stimuli, and understanding these is crucial for elucidating underlying mechanisms AD. Methods In this work, we integrated single-cell spatially resolved transcriptomics data from multiple cohorts brain regions, including microglia...
Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) plays a central role in microglial biology and the pathogenesis of Alzheimer’s disease (AD). Besides DNAX-activating protein 12 (DAP12), communal adaptor for TREM2 many other receptors, cellular interactors remain largely elusive. We employed ‘proximity labeling’ approach using biotin ligase, TurboID, mapping protein–protein interactions live mammalian cells. discovered novel TREM2-proximal proteins with diverse functions,...
The ( p) tellurium-( silicon heterojunction has been prepared by vacuum evaporation of tellurium (Te) films on (Si) substrates. influence the thickness (1000–13000 Å) and annealing electrical properties have investigated. heated substrates (∼425 K) show annealed good adherance Si current-voltage (I-V) characteristics p)Te-( p)Si studied in temperature range 77 to about 360 K. I-V a double saturation indicating applicability Schottky diode model for isotype heterojunctions when large density...
OPINION article Front. Microbiol., 04 November 2022Sec. Infectious Agents and Disease Volume 13 - 2022 | https://doi.org/10.3389/fmicb.2022.1039188