A5080121155- Genomics and Phylogenetic Studies
- Parasitic infections in humans and animals
- Parasite Biology and Host Interactions
- Congenital Anomalies and Fetal Surgery
- Mosquito-borne diseases and control
- Genetics, Bioinformatics, and Biomedical Research
- Malaria Research and Control
- Parasites and Host Interactions
- Cancer Genomics and Diagnostics
- Clostridium difficile and Clostridium perfringens research
- Nematode management and characterization studies
- Cancer-related gene regulation
- Gut microbiota and health
- Animal Genetics and Reproduction
- Trypanosoma species research and implications
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Cardiomyopathy and Myosin Studies
- Scientific Computing and Data Management
- Helminth infection and control
- Genetics, Aging, and Longevity in Model Organisms
- Invertebrate Immune Response Mechanisms
- Cell Image Analysis Techniques
Science for Life Laboratory
2024-2025
Lund University
2024-2025
University of Copenhagen
2021-2024
Novo Nordisk Foundation
2021-2024
Fundação Oswaldo Cruz
2014-2023
National Bioinformatics Infrastructure Sweden
2023
Universidade Federal de Minas Gerais
2016-2019
Centro de Excelência em Bioinformática
2014
Abstract Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni . With World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize genome glabrata, lophotrochozoan protostome, and provide timely important information biology. We describe aspects phero-perception, stress responses, immune function regulation gene expression that support...
Big cat genomes reveal a history of interspecies admixture and adaptive evolution genes underlying development sensory perception.
Background Protein kinases are proven targets for drug development with an increasing number of eukaryotic Kinase (ePK) inhibitors now approved as drugs. Mitogen-activated protein kinase (MAPK) family members connect cell-surface receptors to regulatory within cells and influence a tissue-specific biological activities such cell proliferation, differentiation survival. However, the contributions MAPK pathway schistosome survival unclear. Methodology/Principal Findings We employed RNA...
The parasite Echinococcus canadensis (G7) (phylum Platyhelminthes, class Cestoda) is one of the causative agents echinococcosis. Echinococcosis a worldwide chronic zoonosis affecting humans as well domestic and wild mammals, which has been reported prioritized neglected disease by World Health Organisation. No genomic data, comparative analyses or efficient therapeutic diagnostic tools are available for this severe disease. information presented in study will help to understand peculiar...
Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage thereby determining cardiomyocyte passive stiffness diastolic function, is not well understood. Non-coding RNA transcripts from antisense strand protein-coding genes have been shown to alternative sense gene. The gene locus harbours >80 natural (NATs) unknown function in human heart. aim this study was determine if play...
SUMMARY Plasmodium knowlesi has risen in importance as a zoonotic parasite that been causing regular episodes of malaria throughout South East Asia. The P. genome sequence generated 2008 highlighted and confirmed many similarities differences species, including global view several multigene families, such the large SICAvar family encoding variant antigens known schizont-infected cell agglutination proteins. However, repetitive DNA sequences are bane any project, this other projects have not...
ABSTRACT Plasmodium coatneyi is a protozoan parasite species that causes simian malaria and an excellent model for studying disease caused by the human parasite, P. falciparum . Here we report complete (nontelomeric) genome sequence of Hackeri generated application only Pacific Biosciences RS II (PacBio II) single-molecule real-time (SMRT) high-resolution technology assembly using Hierarchical Genome Assembly Process (HGAP). This first reported to use PacBio technology. approach has proven...
Background In early 2015, a ZIKA Virus (ZIKV) infection outbreak was recognized in northeast Brazil, where concerns over its possible links with infant microcephaly have been discussed. Providing causal link between ZIKV and birth defects is still challenge. MicroRNAs (miRNAs) are small noncoding RNAs (sncRNAs) that regulate post-transcriptional gene expression by translational repression, play important roles viral pathogenesis brain development. The potential for flavivirus-mediated miRNA...
Whole mitogenome sequences (mtDNA) have been exploited for insect ecology studies, using them as molecular markers to reconstruct phylogenies, or infer phylogeographic relationships and gene flow. Recent Anopheles phylogenomic studies provided information regarding the time of deep lineage divergences within genus. Here we report complete 15,393 bp mtDNA aquasalis, a Neotropical human malaria vector. When comparing its structure base composition with other relevant available anopheline...
Rhodnius montenegrensis (Triatominae), a potential vector of Chagas disease, was described after R. robustus-like bugs from southwestern Amazonia. Mitochondrial cytb sequence near-identity with sympatric robustus (genotype II) raised doubts about the taxonomic status montenegrensis, but comparative studies have reported fairly clear morphological and genetic differences between laboratory stocks identified as robustus. Here, we use transcriptome-based approach to investigate this apparent...
<ns4:p>Regional Student Groups (RSGs) of the International Society for Computational Biology Council (ISCB-SC) have been instrumental to connect computational biologists globally and create more awareness about bioinformatics education. This article highlights initiatives carried out by RSGs both nationally internationally strengthen present future community. Moreover, we discuss directions organization will take challenges advance further in ISCB-SC main mission: “Nurture new generation...
In vitro studies of synthetic gut microbial communities (SGMCs) can provide valuable insights into the ecological structure and function microbiota. However, importance quantitative composition an SGMC inoculum its effect on eventual stable in community has not been studied. To address this, we constructed two 114-member SGMCs differing only their composition-one reflecting average human fecal microbiome another mixed equal proportions based cell counts. We inoculated each automated...
Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling is a major challenge, which can be addressed using in vitro fermentors hosting complex microbial communities. Here, by employing 16S rRNA gene amplicon sequencing, we investigated the adaptation and succession human fecal communities an automated multistage fermentor. We performed two independent experiments different donor...
Abstract Background The spring-like sarcomere protein Titin (TTN) is a key determinant of cardiac passive stiffness and diastolic function. Alternative splicing TTN I-band exons produce isoforms with variable size elasticity, but the mechanisms regulating exon skipping isoform composition in human heart are not well studied. Non-coding RNA transcripts from antisense strand protein-coding genes have been shown to regulate alternative sense gene. gene locus harbours >80 unknown function...
Excessive eating and intake of a Western diet negatively affect the intestinal immune system, resulting in compromised glucose homeostasis lower gut bacterial diversity. The G protein-coupled receptor GPR183 regulates cell migration response has been associated with tuberculosis, type 1 diabetes, inflammatory bowel diseases.
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus, first isolated in 1947 from the serum of a pyrexial rhesus monkey caged Forest (Uganda/Africa) 1 . In 2007 ZIKV was reported to been responsible for outbreak relatively mild disease, characterized by rash, arthralgia, and conjunctivitis on Yap Island, western Pacific Ocean 2 past year, has circulating Americas, probably introduced through Easter Island (Chile), French Polynesians 3 early 2015, new recognized northeast Brazil 4 ,...
This report summarizes the scientific content and activities of second edition Brazilian Student Council Symposium organized by Regional Group Brazil (RSG-Brazil), a branch International Society for Computational Biology (ISCB). The event were held preceding thirteen AB3C Conference (13th X-meeting 2017) in São Pedro, Paulo, Brazil, on October 4, 2017. 2nd BR-SCS was attended 78 delegates from all student level (undergraduate, graduate post-docs students) consisted two keynote presentations,...
The human blood fluke parasite Schistosoma mansoni relies on diverse mechanisms to adapt its environments and hosts. Epigenetic play a central role in gene expression regulation, culminating such adaptations. Protein arginine methyltransferases (PRMTs) promote posttranslational modifications, modulating the function of histones non-histone targets. coactivator-associated methyltransferase 1 (CARM1/PRMT4) is one S. proteins with PRMT core domain. We carried out silico analyses verify SmPRMTs...