A5056954210- T-cell and Retrovirus Studies
- Genetics, Bioinformatics, and Biomedical Research
- Parasites and Host Interactions
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Machine Learning in Bioinformatics
- Malaria Research and Control
- vaccines and immunoinformatics approaches
- Biochemical and Molecular Research
- Computational Drug Discovery Methods
- Wikis in Education and Collaboration
- FinTech, Crowdfunding, Digital Finance
- Bacterial biofilms and quorum sensing
- Probiotics and Fermented Foods
- Parasite Biology and Host Interactions
- Transgenic Plants and Applications
- HIV/AIDS drug development and treatment
- Advanced Biosensing Techniques and Applications
- Skin and Cellular Biology Research
- Signaling Pathways in Disease
- Plant Pathogens and Fungal Diseases
- Milk Quality and Mastitis in Dairy Cows
- Environmental DNA in Biodiversity Studies
- Studies on Chitinases and Chitosanases
- Oral microbiology and periodontitis research
Instituto Colombiano de Medicina Tropical
2019-2025
Universidad de Antioquia
2012-2025
Universidad CES
2019-2020
Fundação Oswaldo Cruz
2014-2019
Universidade Federal de Minas Gerais
2014-2017
Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
2014
Centro de Excelência em Bioinformática
2014
Universidad del Valle
2008-2012
Biological networks are often used to represent complex biological systems, which can contain several types of entities. Analysis and visualization such is supported by the Cytoscape software tool its many apps. While earlier versions stringApp focused on providing intraspecies protein-protein interactions from STRING database, new 2.0 greatly improves support for heterogeneous networks. Here, we highlight functionality that makes it possible create proteins as well other entities...
Introduction: Streptococcus uberis is a poorly controlled cause of bovine intramammary infections and common motivation for the use antibiotics in dairy farms worldwide. Therefore, studying genomic characteristics this pathogen fundamental to understand its complex epidemiology behavior against antimicrobials. Methods: A comparative analysis 10 S. strains was performed their antimicrobial susceptibility assessed. Results: Ten different novel sequence types were found, genes (tetM, tetO,...
The study of molecular host–parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention treatment infectious diseases require a clear understanding crosstalk between parasites their hosts. Yet, large-scale experimental identification remains challenging, use computational predictions becomes then necessary. Here, we propose integrative approach predict protein–protein interaction (PPI) networks resulting from human by 15...
Background The Andean condor ( Vultur gryphus ) is the largest scavenger in South America. This predatory bird plays a crucial role their ecological niche by removing carcasses. We report first metagenomic analysis of gut microbiome. Methods work analyzed shotgun metagenomics data from mixture fifteen captive Chilean condors. To filter eukaryote contamination, we employed BWA-MEM v0.7. Taxonomy assignment was performed using Kraken2 and MetaPhlAn v2.0 all filtered reads were assembled...
The cystatin family comprises cysteine protease inhibitors distributed in 3 subfamilies (I25A-C). Family members lacking activity are currently unclassified. Little is known about the evolution of Schistosoma cystatins, their physiological roles, and expression patterns parasite life cycle. present study aimed to identify homologs predicted proteome three species other Platyhelminthes. We analyzed amino acid sequence diversity focused identification protein signatures establish evolutionary...
The field of single-cell biology is growing rapidly and generating large amounts data from a variety species, disease conditions, tissues, organs. Coordinated efforts such as CZI CELLxGENE, HuBMAP, Broad Institute Single Cell Portal, DISCO, allow researchers to access volumes curated datasets. Although the majority scRNAseq experiments, wide range other modalities are represented well. These resources have created an opportunity build expand computational ecosystem develop tools necessary...
Parasitic diseases pose a significant global health challenge with substantial socioeconomic impact, especially in developing countries. Combatting these is difficult due to two factors: the resistance developed by parasites existing drugs and underfunded research efforts resolve host-parasite interactions. To address latter, we focused on 276 human-parasite interaction predictions involving 15 parasitic species known cause infections humans. We aimed validate interactions using...
Aspergillus welwitschiae causes bole rot disease in sisal (Agave sisalana and related species) which affects the production of natural fibers Brazil, main worldwide producer fibers. This fungus is a saprotroph with broad host range. Previous research established A. as only causative agent field, but little known about evolution this species its strains. In work, we performed comparative genomics analysis 40 We show conflicting molecular identity species, one sisal-infecting strain sharing...
<ns4:p>Regional Student Groups (RSGs) of the International Society for Computational Biology Council (ISCB-SC) have been instrumental to connect computational biologists globally and create more awareness about bioinformatics education. This article highlights initiatives carried out by RSGs both nationally internationally strengthen present future community. Moreover, we discuss directions organization will take challenges advance further in ISCB-SC main mission: “Nurture new generation...
Staphylococcus aureus represent a serious threat to public health due food safety, antibiotic resistance, and the potential zoonotic transmission of strains between dairy cattle humans. Biofilm formation by S. results in chronicity infections which confers protection against immune response antibiotics. Likewise, biofilm allows exchange mobile genetic material among different through microbial interactions inside matrix. In Colombia, where this pathogen continues be one main isolated from...
<ns4:p>Since 2014, the ISCB Latin American Student Council Symposium (LA-SCS) serves as main biannual activity where students from all levels, postdocs and early researchers entire region can gather to discuss recent advances in fields of bioinformatics computational biology. This time we faced a major unexpected obstacle, worldwide pandemic that has completely disrupted human activities at planetary scale. Countless conferences have been either canceled, reprogrammed for next year or moved...
Introduction: Despite efforts to control malaria, around 10% of the world population is at risk acquiring this disease. Plasmodium falciparum accounts for majority severe cases and deaths. Malaria programs have failed due therapeutic failure first-line antimalarials parasite resistance. Thus, new better alternatives are required. Proteomic analysis allows determination protein expression levels under drug pressure, leading identification targets their mechanisms action.Objective: The aim...
Gene Regulatory Networks (GRNs) allow the study of regulation gene expression whole genomes. Among most relevant advantages using networks to depict this key process, there is visual representation large amounts information and application graph theory generate new knowledge. Nonetheless, despite many uses GRNs, it still difficult expensive assign Transcription Factors (TFs) specific genes. ChIP-Seq allows determination TF Binding Sites (TFBSs) over genomes, but an technique that can only be...
<strong>Objective</strong>. Using molecular simulation, we studied the influence of Mg2+ ions on binding mode HTLV-I Integrase (IN) catalytic domain (modeled by homology) with 3,5- Dicaffeoylquinic Acid (DCQA). homology model was built using template-like crystallographic data IN solved for Avian Sarcoma Virus (VSA, pdb: 1VSD). <strong>Materials and</strong> <strong>methods</strong>. In order to analyze role in interaction or coupling between 3,5-DCQA and...
Wikipedia is one of the most important channels for public communication science and frequently accessed as an educational resource in computational biology. Joint efforts between International Society Computational Biology (ISCB) taskforce WikiProject Molecular (a group expert editors) have considerably improved biology representation on recent years. However, there still urgent need further improvement quality, especially when compared to related scientific fields such genetics medicine....
Abstract The study of molecular host–parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention treatment infectious diseases require clear understanding crosstalk between parasites their hosts. yet, experimental large–scale identification remains challenging use in silico predictions becomes then necessary. Here, we propose a computational integrative approach predict protein–protein interaction (PPI) networks resulting...
Introduction. Although the integration of human T-cell lymphotropic virus type I into T-cells is not a random process, mechanistic details are understood.Objectives. The characteristics flanking host chromatin were evaluated at sites in adult leukaemia/lymphoma (ATLL) patients infected with virus.Materials and methods. From seven leukemic Colombian positive for (HTLV-I), lymphocyte DNA samples extracted amplified by inverse polymerase chain reaction (IPCR). Clonal expansion genome nucleotide...