A5100777252- Circadian rhythm and melatonin
- Mast cells and histamine
- Free Radicals and Antioxidants
- Microbial Metabolic Engineering and Bioproduction
- Plant Gene Expression Analysis
- Postharvest Quality and Shelf Life Management
- Horticultural and Viticultural Research
- Plant Physiology and Cultivation Studies
- Evolution and Genetic Dynamics
- Polyamine Metabolism and Applications
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Environmental and Cultural Studies in Latin America and Beyond
- Escherichia coli research studies
- Coordination Chemistry and Organometallics
- Oral and gingival health research
- Protease and Inhibitor Mechanisms
- Bat Biology and Ecology Studies
- Isotope Analysis in Ecology
- Cultural Heritage Materials Analysis
- Banana Cultivation and Research
- Pharmacology and Obesity Treatment
- Botulinum Toxin and Related Neurological Disorders
- Clostridium difficile and Clostridium perfringens research
- Aluminum toxicity and tolerance in plants and animals
Universidad Mayor
2020-2024
Fundación Ciencia and Vida
2024
University of Chile
2007-2024
University of Concepción
2023
University of Nevada, Las Vegas
2023
Pontificia Universidad Católica de Chile
2022
University of Parma
2003-2009
Centro de Edafología y Biología Aplicada del Segura
2007
University of Tarapacá
2007
University of Calgary
2007
Marker-assisted selection (MAS) in stone fruit (Prunus species) breeding is currently difficult to achieve due the polygenic nature of most relevant agronomic traits linked quality. Genotyping by sequencing (GBS), however, provides a large quantity useful data suitable for fine mapping using Single Nucleotide Polymorphisms (SNPs) from reference genome. In this study, GBS was used genotype 272 seedlings three F1 Japanese plum (P. salicina Lindl) progenies derived crossing '98-99' (as common...
Abstract Microglia are resident immune cells within the central nervous system (CNS). They become activated following neurological insults and increase their expression of cytokines. Also elevated in CNS injuries proteases, including matrix metalloproteinases (MMPs) A disintegrin (ADAMs). The spectrum metalloproteinase members expressed by microglia systemic leukocytes that infiltrate injured is unknown, as functions. We determined levels transcripts encoding all 24 MMPs, nine ADAMs, four...
Exposure of C2C12 muscle cells to hypertonic stress induced an increase in cell content creatine transporter mRNA and transport activity, which peaked after about 24 h incubation at 0.45 osmol (kg H 2 O) −1 . This induction activity was prevented by addition either cycloheximide, inhibit protein synthesis, or actinomycin D, RNA synthesis. Creatine uptake these is largely Na + dependent kinetic analysis revealed that its under conditions resulted from V max the ‐dependent component, with no...
The three-dimensional quantitative structure-activity relationship comparative molecular field analysis (3D-QSAR CoMFA) approach was applied to some classes of melatonin (MLT) membrane receptor ligands, with the principal aim exploring correlation between their steric features and MT(2)-selective antagonism. Binding data obtained from cloned MT(1) MT(2) subtypes were used develop 3D-QSAR models for agonists antagonists at two subtypes, looking structural requirements subtype selectivity. In...
The class of N-(anilinoethyl)amides includes melatonin receptor ligands with varied subtype selectivity and intrinsic activity. One these ligands, the MT(2)-selective partial agonist UCM765 (N-{2-[(3-methoxyphenyl)phenylamino]ethyl}acetamide), had evidenced hypnotic effects in rodents at doses > or =40 mg kg(-1) (s.c.), spite its sub-nanomolar affinity for human receptors. Supposing that low vivo potency could be due, least part, to metabolic liability rat liver, was incubated liver S9...
5-Methoxy-2-(N-acetylaminoethyl)indole (5d), a melatonin analogue derived from the transposition of acetylaminoethyl side chain C3 to C2 indole nucleus, had been previously characterized as low affinity antagonist at MT1 and MT2 membrane receptors; this molecule is endowed with good in vitro antioxidant cytoprotective potency rat cerebellar cell cultures, comparable or better than those melatonin. In order further investigate role structure-antioxidant activity relationships cytoprotection,...
Clostridium baratii strains are rare opportunistic pathogens associated with botulism intoxication. They have been isolated from foods, soil and be carried asymptomatically or cause outbreaks. Is not taxonomically related to botulinum, but some equipped BoNT/F7 cluster. Despite their relationship diseases, our knowledge regarding the genomic features phylogenetic characteristics is limited. We analyzed pangenome of C. understand diversity this species. compared existing genomes in public...
Understanding the interactions between microorganisms and their impact on bacterial behavior at community level is a key research topic in microbiology. Different methods, relying experimental or mathematical approaches based diverse properties of bacteria, are currently employed to study these interactions. Recently, use metabolic networks understand pairs has increased, highlighting relevance this approach characterizing bacteria. In study, we leverage representation bacteria through build...
Consumption of fresh fruit is known to protect against non-communicable diseases due the fruit's content in compounds with an antioxidant capacity, among them polyphenols. Asian plums (Prunus salicina L.) accumulate more than 40 phenolic compounds, a remarkable diversity their profiles, depending on variety and environmental conditions. Although candidate genes have been indicated control this trait, loci controlling its phenotypic variation not yet defined species. The aim work was identify...
<ns4:p>Since 2014, the ISCB Latin American Student Council Symposium (LA-SCS) serves as main biannual activity where students from all levels, postdocs and early researchers entire region can gather to discuss recent advances in fields of bioinformatics computational biology. This time we faced a major unexpected obstacle, worldwide pandemic that has completely disrupted human activities at planetary scale. Countless conferences have been either canceled, reprogrammed for next year or moved...
A continuación se presentan los resultados obtenidos en trabajos de excavación y análisis del sitio Playa Negra 9 (PN-9) ubicado la bahía Concepción, región
Genotyping by sequencing (GBS) provides a large quantity of useful data suitable for the identification single nucleotide polymorphisms (SNPs), facilitating accurate genomic studies in plant species. In this study, GBS-based SNPs were used to characterise 11 Japanese plum cultivars and explore their natural allelic diversity relation most important phenology events (flowering date, ripening date fruit development period) quality traits (weight, shape, skin flesh colour, over chlorophyll...
Abstract A series of carbamate derivatives the H 3 antagonist ROS203 ( 1 ) were prepared, and their lipophilicity steric hindrance modulated by introducing linear or branched alkyl chains various lengths. In vitro stability studies conducted to evaluate how structural modulations affect intrinsic reactivity carbamoyl moiety its recognition metabolic enzymes. Linear carbamates most susceptible enzymatic hydrolysis, with bioconversion rates being higher in rat liver plasma. Chain ramification...
O empoderamento feminino desempenha um papel fundamental na promoção da saúde e prevenção de Infecções Sexualmente Transmissíveis (ISTs), incluindo o HIV/AIDS. É uma ferramenta poderosa sexual reprodutiva ISTs, Ele envolve a educação, autonomia, acesso serviços saúde, redução violência gênero, apoio social comunitário independência financeira. Todos esses fatores juntos contribuem para melhor bem-estar das mulheres suas comunidades. fortalecimento autonomia é pilar essencial igualdade gênero...
Abstract Maternal nutrient restriction in twin-bearing ewes reduces the colostrum protein content, resulting reduced postnatal growth and greater lamb mortality twin- compared with single-bearing ewes. N-carbamylglutamate (NCG), an analogue of N-acetylglutamate increases endogenous arginine synthesis is postulated to influence fetal development potentially survival. The effect maternal supplementation NCG mid-late gestation on quality status nutrient-restricted has not been reported. aim...