A5080796605- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Free Radicals and Antioxidants
- Drug Transport and Resistance Mechanisms
- Chemical Reaction Mechanisms
- Molecular spectroscopy and chirality
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Metabolism and Genetic Disorders
- Chemical Reactions and Isotopes
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Synthesis and Biological Evaluation
- Protein Structure and Dynamics
- Chemical and Physical Properties in Aqueous Solutions
- Spectroscopy and Quantum Chemical Studies
- Parkinson's Disease Mechanisms and Treatments
- Click Chemistry and Applications
- Chemistry and Stereochemistry Studies
- Electrochemical Analysis and Applications
- Lipid Membrane Structure and Behavior
- Phenothiazines and Benzothiazines Synthesis and Activities
- Analytical Methods in Pharmaceuticals
- Enzyme Catalysis and Immobilization
University of Lausanne
2009-2022
University Hospital of Lausanne
2006-2021
Hôpital Orthopédique de la Suisse Romande
2014
GTx (United States)
2013
Royal North Shore Hospital
2012
University of Parma
1997-2010
Universidade de Santiago de Compostela
2007
University of Bari Aldo Moro
1993-2007
University of Milan
2004-2006
University of Geneva
2004
Predicting blood-brain barrier (BBB) permeation remains a challenge in drug design. Since it is impossible to determine experimentally the BBB partitioning of large numbers preclinical candidates, alternative evaluation methods based on computerized models are desirable. The present study was conducted demonstrate value descriptors derived from 3D molecular fields estimating set compounds and produce simple mathematical model suitable for external prediction. method used (VolSurf) transforms...
A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE values in the micromolar range (3-100 microM). kinetic study showed that most acted noncompetitive This finding may be interest context Alzheimer's disease because recent observations suggest MAO inhibition might decrease beta-amyloid deposition.
A large series of coumarin derivatives (71 compounds) were tested for their monoamine oxidase and B (MAO-A MAO-B) inhibitory activity. Most the compounds acted preferentially on MAO-B with IC50 values in micromolar to low-nanomolar range; high activities toward MAO-A also measured sulfonic acid esters. The most active compound was 7-[(3,4-difluorobenzyl)oxy]-3,4-dimethylcoumarin, an value 1.14 nM. QSAR study 7-X-benzyloxy meta-substituted 3,4-dimethylcoumarin acting yielded good statistical...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMorphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicityPierre Alain Carrupt, Bernard Testa, Antoine Bechalany, Nabil El Tayar, Patrick Descas, Daniel PerrissoudCite this: J. Med. Chem. 1991, 34, 4, 1272–1275Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April...