A5022629146- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin D Research Studies
- Cardiac Imaging and Diagnostics
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Coronary Interventions and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Healthcare Regulation
- Neurofibromatosis and Schwannoma Cases
- Alzheimer's disease research and treatments
- Genomics and Chromatin Dynamics
- T-cell and B-cell Immunology
- Healthcare during COVID-19 Pandemic
- Parkinson's Disease Mechanisms and Treatments
- Adrenal Hormones and Disorders
- Advanced MRI Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Cardiac and Coronary Surgery Techniques
- Radiation Dose and Imaging
- Bariatric Surgery and Outcomes
- Acute Myocardial Infarction Research
- Autophagy in Disease and Therapy
- Bioinformatics and Genomic Networks
- Gene Regulatory Network Analysis
Universidad Mayor
2021-2023
Universidade Federal do Rio Grande do Sul
2011-2015
Hospital de Clínicas de Porto Alegre
2009-2013
Hospital de Clínicas
2009-2013
Vitamin D deficiency has been described in systemic lupus erythematosus (SLE). BsmI VDR (vitamin receptor) gene polymorphism was associated with SLE Asian patients. Studies Brazilian populations have not realized. A case-control study 195 patients and 201 healthy controls conducted to investigate the influence of FokI polymorphisms on susceptibility SLE. In addition, 25-hydroxyvitamin [25(OH)D] measured evaluate possible associations polymorphic variants clinical laboratory expressions...
The mannose-binding lectin gene (MBL-2) has emerged as a candidate for systemic lupus erythematosus susceptibility, but studies in Brazilian population have not been conducted. To examine potential associations of alleles G57E, G54D, IVSnt5, R52C and R52H with susceptibility to clinical expression southern patients, we conducted case-control study 327 consecutive patients diagnosis 345 healthy controls. Genotyping was performed by restriction fragment length polymorphism-polymerase chain...
Neurofibromatosis type 1 (NF1) patients are more likely to have vitamin D deficiency when compared the general population. This study aimed determine levels of 25-OH-vitamin [25(OH)D] in individuals with NF1 and disease-unaffected controls analyze FokI BsmI VDR gene polymorphisms a case control group. Vitamin were between group 45 from Southern Brazil healthy matched by sex, skin type, age. Genotypic allelic frequencies obtained same 150 controls. 25(OH)D or insufficiency was not frequent...
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by protein accumulation in brain as a main neuropathological hallmark. Among them, Aβ42 peptides tend to aggregate and create oligomers plaques. Macroautophagy, form of autophagy double-membrane vesicle, plays crucial role maintaining neuronal homeostasis degrading aggregates dysfunctional organelles quality control process. Recently, DEF8, relatively uncharacterized protein, has been proposed...
Gene Regulatory Networks (GRNs) allow the study of regulation gene expression whole genomes. Among most relevant advantages using networks to depict this key process, there is visual representation large amounts information and application graph theory generate new knowledge. Nonetheless, despite many uses GRNs, it still difficult expensive assign Transcription Factors (TFs) specific genes. ChIP-Seq allows determination TF Binding Sites (TFBSs) over genomes, but an technique that can only be...
<h3>Background</h3> Vitamin D has pleiotropic actions on many chronic diseases. Multiple studies have confirmed vitamin deficiency in patients with systemic lupus erythematosus (SLE). Genetic polymorphisms located <i>VDR</i> gene and low levels of 25-hydroxyvitamin (25OHD) may increase the risk cardiovascular event. The relationship factors SLE been described, but more are needed to further clarification. <h3>Objectives</h3> To study influence disease patients. <h3>Methods</h3> One hundred...