A5076752462- Alzheimer's disease research and treatments
- Microbial Community Ecology and Physiology
- Autophagy in Disease and Therapy
- Polar Research and Ecology
- Protist diversity and phylogeny
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Down syndrome and intellectual disability research
- Parkinson's Disease Mechanisms and Treatments
- Signaling Pathways in Disease
- Cutaneous Melanoma Detection and Management
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Microbial metabolism and enzyme function
- Heavy metals in environment
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Head and Neck Surgical Oncology
- Plant-Microbe Interactions and Immunity
- Environmental and Cultural Studies in Latin America and Beyond
- Mercury impact and mitigation studies
- Legume Nitrogen Fixing Symbiosis
- Microbial Fuel Cells and Bioremediation
- Curcumin's Biomedical Applications
Pontificia Universidad Católica de Chile
2022-2025
Advanced Center for Chronic Diseases
2020-2025
Universidad Mayor
2020-2023
University of Chile
2020-2022
University of the Andes
2010-2016
Universidad de Los Andes
2013
Background The renin-angiotensin system (RAS) plays a pivotal role in regulating blood volume, systemic vascular resistance, and electrolyte balance, serving as key component of cardiovascular health. Recent findings highlight the angiotensin II (Ang II) inducing autophagy through receptor type 1 (AT1R). Autophagy, process self-degradation turnover cellular components, is homeostatic response that eliminates superfluous materials. Abnormal promotes cardiomyocyte loss critical hypertrophy...
Aging is closely associated with cardiovascular diseases, the leading cause of mortality worldwide. Mitochondrial dysfunction a hallmark aging because it generates most heart's ATP at cristae, specialized sub-compartments where OXPHOS takes place. In this study, we used multiple-scale electron microscopy approaches to evaluate age-related mitochondrial and cristae ultrastructural alterations in human mouse hearts. We found that aged patients' hearts displayed reduced density as seen by TEM,...
Even though tropical glaciers are retreating rapidly and many will disappear in the next few years, their microbial diversity remains to be studied depth. In this paper we report on biodiversity of culturable fraction bacteria colonizing Pico Bolívar’s glacier ice subglacial meltwaters, at ∼4950 m Venezuelan Andean Mountains. Microbial cells diverse morphologies exhibiting uncompromised membranes were present densities ranging from 1.5 × 10 4 4.7 cells/mL 4.1 5 9.6 meltwater. Of 89 pure...
Dysfunction of the aging heart is a major cause death in human population. Amongst other tasks, mitochondria are pivotal to supply working with ATP. The mitochondrial inner membrane (IMM) ultrastructure tailored meet these demands and provide nano-compartments for specific tasks. Thus, function morphology closely coupled. Senescent cardiomyocytes from mouse display alterations membrane. To study relation between architecture, dynamics hardly possible living organisms. Here, we present two...
Background: Disturbances in the autophagy/endolysosomal systems are proposed as early signatures of Alzheimer’s disease (AD). However, few studies available concerning autophagy gene expression AD patients. Objective: To explore differential classical genes involved pathway, among them a less characterized one, DEF8 (Differentially expressed FDCP 8), initially considered Rubicon family member, peripheral blood mononuclear cells (PBMCs) from individuals with mild cognitive impairment (MCI)...
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by protein accumulation in brain as a main neuropathological hallmark. Among them, Aβ42 peptides tend to aggregate and create oligomers plaques. Macroautophagy, form of autophagy double-membrane vesicle, plays crucial role maintaining neuronal homeostasis degrading aggregates dysfunctional organelles quality control process. Recently, DEF8, relatively uncharacterized protein, has been proposed...
Alzheimer's disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates neurons. Rubicon a well-established inhibitor of all cells. However, participates different pathways depending on cell type, and little information currently available neuronal Rubicon's role AD context. Here, we investigated cell-specific expression postmortem samples from patients 5xFAD mice...