A5072001336- Parkinson's Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- MicroRNA in disease regulation
- Phytochemicals and Antioxidant Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Cardiac Ischemia and Reperfusion
- Alzheimer's disease research and treatments
- Organ Transplantation Techniques and Outcomes
- Reproductive System and Pregnancy
- Electrospun Nanofibers in Biomedical Applications
- Restless Legs Syndrome Research
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Biochemical Analysis and Sensing Techniques
- Cell Adhesion Molecules Research
- Biochemical and biochemical processes
- Caveolin-1 and cellular processes
- Transplantation: Methods and Outcomes
- Neurogenetic and Muscular Disorders Research
- Food Drying and Modeling
Center for Climate and Resilience Research
2020-2025
Universidad Mayor
2020-2025
Instituto de Neurociencia Biomédica
2023-2025
University of Chile
2020-2025
Universidad de Los Andes, Chile
2019-2025
San Sebastián University
2023-2024
Abstract Insulin-like growth factor 2 (IGF2) and autophagy-related genes have been proposed as biomolecules of interest related to idiopathic Parkinson’s disease (PD). The objective this study was determine the IGF2 IGF1 levels in plasma peripheral blood mononuclear cells (PBMCs) from patients with moderately advanced PD explore potential correlation same samples. patients' were measured by ELISA, expression determined real-time PCR Western blot PBMCs. evaluated PCR. results show a...
Caveolin-1 (CAV1) is a membrane protein that promotes migration, invasion and metastasis of cancer cells when phosphorylated on tyrosine-14 (Y14) by cell intrinsic mechanism involving the activation novel Rab5-Rac1 signaling axis. Moreover, CAV1 expressed in aggressive included into extracellular vesicles (EVs) such EVs increase metastatic potential recipient lower grade cells. However, relevance Y14 phosphorylation these extrinsic EV-stimulated events remained to be determined. Here we used...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in Substantia Nigra, leading to motor impairment. A hallmark PD presence misfolded α-synuclein (α-syn) proteins and their neurotoxic accumulations, contributing neuronal loss. Additionally, inflammatory response plays critical role modulating neurodegeneration process PD. Moreover, peripheral macrophages recognize α-syn, triggering chronic inflammation both bloodstream brain...
Despite the different strategies used to treat ovarian cancer, around 70% of women/patients eventually fail respond therapy. Cancer stem cells (CSCs) play a role in treatment failure due their chemoresistant properties. This capacity resist chemotherapy allows CSCs interact with components tumor microenvironment, such as mesenchymal (MSCs), and thus contribute tumorigenic processes. Although participation MSCs progression is well understood, it remains unclear how induce pro-tumorigenic...
In this study, vacuum drying (VD) was employed as an approach to protect the bioactive components of and produce dried broccoli powders with a high biological activity. To achieve these goals, effects temperature (at five levels 50, 60, 70, 80 90 °C) constant pressure (10 kPa) were evaluated. The results show that, increasing temperature, time decreased. Based on statistical tests, Brunauer–Emmett–Teller (BET) model found fit well sorption isotherms, whereas Midilli Kucuk kinetics. VD has...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and no efficient therapy able to cure or slow down PD available. In this study, dehydrated red cabbage was evaluated as a novel source of bio-compounds with neuroprotective capacity. Convective drying carried out at different temperatures. Total phenolics (TPC), flavonoids (TFC), anthocyanins (TAC), glucosinolates (TGC) were determined using spectrophotometry, amino acid profile by LC-DAD fatty GC-FID. Phenolic...
Parkinson's disease (PD) is the second most common late-onset neurodegenerative and predominant cause of movement problems. PD characterized by motor control impairment extensive loss dopaminergic neurons in substantia nigra pars compacta (SNpc). This selective neuronal part triggered intracellular protein inclusions called Lewy bodies, which are composed mainly misfolded alpha-synuclein (α-syn) protein. We previously reported insulin-like growth factor 2 (IGF2) as a key downregulated...
Chemoresistance is a common problem in ovarian cancer (OvCa) treatment, where resistant cells, response to chemotherapy, secrete small extracellular vesicles (sEVs), known as chemo-sEVs, that transfer resistance recipient cells. sEVs are formed intraluminal (ILVs) within multivesicular endosomes (MVEs), whose trafficking regulated by Ras-associated binding (RAB) GTPases mediate secretion or lysosomal degradation. A decrease function can promote secretion, but the relationship between MVEs...
Abstract Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in Substantia Nigra , which causes motor deficits. The most common histopathological feature PD presence α-synuclein (α-syn) misfolding protein and neurotoxic accumulations leads to neuronal loss. Additionally, inflammatory response arises as relevant factor engage modulate neurodegeneration process PD. An increase proinflammatory cytokines blood brain samples has...
<title>Abstract</title> Caveolin-1 (CAV1) is a membrane protein that promotes migration, invasion and metastasis of cancer cells when phosphorylated on tyrosine-14 (Y14) by cell intrinsic mechanism involving the activation novel Rab5-Rac1 signaling axis. Moreover, CAV1 expressed in aggressive included into extracellular vesicles (EVs) such EVs increase metastatic potential recipient lower grade cells. However, relevance Y14 phosphorylation these extrinsic EV-stimulated events remained to be...
Alzheimer's disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates neurons. Rubicon a well-established inhibitor of all cells. However, participates different pathways depending on cell type, and little information currently available neuronal Rubicon's role AD context. Here, we investigated cell-specific expression postmortem samples from patients 5xFAD mice...
Abstract Parkinson's disease (PD) is the second most common late-onset neurodegenerative and predominant cause of movement problems. PD characterized by motor control impairment extensive loss dopaminergic neurons in substantia nigra pars compacta (SNpc). This selective neuronal part triggered intracellular protein inclusions called Lewy bodies, which are composed mainly misfolded alpha-synuclein (α-syn) protein. We previously reported insulin-like growth factor 2 (IGF2) as a key...
ABSTRACT Ovarian cancer (OvCa) is an aggressive disease usually treated with cisplatin (CDDP)-based therapy. However, among the different types of cancers CDDP, OvCa commonly develops chemoresistance to this treatment. The small extracellular vesicles (sEVs) play a central role in chemoresistance. In response chemotherapy, resistant cells secrete sEVs named chemo-sEVs characterized by specific cargo landscape content involved transfer recipient cells. encompass variety vesicle types,...
Abstract Insulin-like growth factor 2 (IGF2) and autophagy-related genes have been proposed as interesting biomolecules related to idiopathic Parkinson’s disease (PD). The objective of this study was determine the IGF2 IGF1 levels in plasma peripheral blood mononuclear cells (PBMCs) from patients with moderately advanced PD explore potential correlation same samples. patients' were measured by ELISA, expression determined real-time PCR Western blot PBMCs. evaluated PCR. results show a...