A5004006180- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Neuropeptides and Animal Physiology
- Neuroscience, Education and Cognitive Function
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Sphingolipid Metabolism and Signaling
- Nuclear Receptors and Signaling
- Axon Guidance and Neuronal Signaling
- Eicosanoids and Hypertension Pharmacology
Instituto de Investigación Biomédica de Málaga
2018-2025
Universidad de Málaga
2018-2025
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in Substantia Nigra, leading to motor impairment. A hallmark PD presence misfolded α-synuclein (α-syn) proteins and their neurotoxic accumulations, contributing neuronal loss. Additionally, inflammatory response plays critical role modulating neurodegeneration process PD. Moreover, peripheral macrophages recognize α-syn, triggering chronic inflammation both bloodstream brain...
Abstract Erasing memories of cocaine–stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult neurogenesis (AHN) is a promising strategy because the addition new neurons may not only facilitate learning but also modify previous connections and weaken retrograde memories. To investigate whether increasing AHN prompted forgetting contextual cocaine associations, mice trained in cocaine‐induced conditioned place...
Cocaine addiction is a chronic disorder in which the person loses control over drug use. The past memories of stimuli associated with are relevant clinical problem, since they trigger compulsive drug-seeking and drug-taking habits. Furthermore, these persistent drug-related seemingly coexist cognitive decline that predicts worse therapeutic output. Here, we use new animal model cocaine-altered cognition allowed to observe events same individual study their relationship. Mice were chronically...
Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes spontaneous –unconditioned- motor and exploratory responses are scarcely reported. In this study, mice were administered with (20 mg/kg/day) or vehicle for 12 consecutive days. After 24 days of drug abstinence, a behavioral assessment was carried out drug-free conditions unfamiliar environments (i.e. no cocaine-associated cues presented). The...
Abstract Cocaine is a widely used psychostimulant drug whose repeated exposure induces persistent cognitive/emotional dysregulation, which could be predictor of relapse in users. However, there scarce evidence on effective treatments to alleviate these symptoms. Environmental enrichment (EE) has been shown associated with improved synaptic function and cellular plasticity changes related adult hippocampal neurogenesis (AHN), resulting cognitive enhancement. Therefore, EE mitigate the...
Abstract Intrinsic exploratory biases are an innate motivation for exploring certain types of stimuli or environments over others, and they may be associated with cognitive, emotional, even personality‐like traits. However, their neurobiological basis has been scarcely investigated. Considering the involvement hippocampus in novelty recognition spatial pattern separation tasks, this work researched role adult hippocampal neurogenesis (AHN) intrinsic bias a perceptually complex object mice....
Abstract Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in Substantia Nigra , which causes motor deficits. The most common histopathological feature PD presence α-synuclein (α-syn) misfolding protein and neurotoxic accumulations leads to neuronal loss. Additionally, inflammatory response arises as relevant factor engage modulate neurodegeneration process PD. An increase proinflammatory cytokines blood brain samples has...