A5054708460- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Sphingolipid Metabolism and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Zebrafish Biomedical Research Applications
- Tryptophan and brain disorders
- Nerve injury and regeneration
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Circadian rhythm and melatonin
- Lysosomal Storage Disorders Research
- Olfactory and Sensory Function Studies
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Neuroscience, Education and Cognitive Function
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Developmental and Educational Neuropsychology
- Pain Mechanisms and Treatments
Universidad de Málaga
2016-2025
Instituto de Investigación Biomédica de Málaga
2015-2024
Universidade Paranaense
2024
Andalusian Centre for Nanomedicine and Biotechnology
2023
Karolinska Institutet
2015
Universidad de Oviedo
1996-2000
Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein–coupled receptors. At least 2 LPA receptors, LPA1 and LPA2, are expressed in the developing brain, former enriched neurogenic ventricular zone (VZ), suggesting normal role neurogenesis. Despite numerous studies reporting effects of exogenous using vitro neural models, first loss-of-function mutants reported did not show gross cerebral cortical defects 50% that survived...
Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown role for this and its LPA 1 receptor regulation of plasticity neurogenesis adult However, no systematic been conducted to investigate whether is involved behavior. In study, we studied phenotype maLPA ‐null mice, which bear targeted deletion at lpa locus, battery tests examining neurologic performance, habituation exploratory behavior response low mild anxiety environments...
Background The lysophosphatidic acid LPA1 receptor regulates plasticity and neurogenesis in the adult hippocampus. Here, we studied whether absence of modulated detrimental effects chronic stress on hippocampal spatial memory. Methodology/Principal Findings Male LPA1-null (NULL) wild-type (WT) mice were assigned to control or conditions (21 days restraint, 3 h/day). Immunohistochemistry for bromodeoxyuridine endogenous markers was performed examine cell proliferation, survival, number...
Insulin-like growth factor-II (IGF-II) is a naturally occurring hormone that exerts neurotrophic and neuroprotective properties in wide range of neurodegenerative diseases ageing. Accumulating evidence suggests the effects IGF-II brain may be explained by its binding to specific transmembrane receptor, IGFII/M6P receptor (IGF-IIR). However, relatively little known regarding role through IGF-IIR neuroprotection. Here, using adult cortical neuronal cultures, we investigated whether exhibits...
Abstract Chronic alcohol consumption is associated with neurocognitive and memory deficits, dramatically affecting plasticity connectivity, maximal expression as dementia. Neurotrophic factors may contribute to alcohol‐related cognitive decline. For further investigation, a cross‐sectional study was performed evaluate the association of impairment, by using frontal assessment battery, loss, failures everyday, circulating levels neurotrophin brain‐derived neurotrophic factor (BDNF) 3 (NT‐3)...
Galanin (GAL) plays a role in mood regulation. In this study we analyzed the action of active N-terminal fragment [GAL(1–15)] anxiety- and depression-related behavioral tests rats. The effect GAL(1–15) was forced swimming test, tail suspension open field light/dark test. proximity GAL1 GAL2 receptors examined with ligation assay (PLA). We tested GAL involved effects receptor antagonist M871 an vivo model siRNA knockdown or were also studied cell line RN33B. induced strong depression-like...
The cocaine addiction disorder is notably aggravated by concomitant cognitive and emotional pathology that impedes recovery. We studied whether a persistent cognitive/emotional dysregulation in mice withdrawn from holds neurobiological correlate within the hippocampus, limbic region with key role anxiety memory but has been scarcely investigated research. Mice were submitted to chronic (20 mg/kg/day for 12 days) or vehicle treatment followed 44 drug-free days. Some then assessed on battery...
Abstract Anxious depression is a prevalent disease with devastating consequences and poor prognosis. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The LPA1 receptor one of six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts as an intracellular signalling molecule. loss induces anxiety several behavioural changes that have been strongly associated depression. In study, we sought to...
We investigated the role of adult hippocampal neurogenesis in cocaine-induced conditioned place preference (CPP) behaviour and functional brain circuitry involved. Adult was pharmacologically reduced with temozolomide (TMZ), mice were tested for CPP to study c-Fos expression hippocampus extrahippocampal addiction-related areas. Correlational multivariate analysis revealed that, under normal conditions, showed widespread connectivity other areas strongly contributed module associated...
Abstract Erasing memories of cocaine–stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult neurogenesis (AHN) is a promising strategy because the addition new neurons may not only facilitate learning but also modify previous connections and weaken retrograde memories. To investigate whether increasing AHN prompted forgetting contextual cocaine associations, mice trained in cocaine‐induced conditioned place...
Combining physical and cognitive training has been suggested to promote further benefits on brain cognition, which could include synergistic improvement of hippocampal neuroplasticity. In this paper, we investigated whether treadmill exercise followed by a working memory in the water maze increase adult neurogenesis greater extent than either treatment alone. Our results revealed that ten days scheduled running enhance cell proliferation/survival short-term as well performance maze....
The lysophosphatidic acid LPA1 receptor has recently been involved in the adaptation of hippocampus to chronic stress. absence aggravates stress-induced impairment both hippocampal neurogenesis and apoptosis that were accompanied with hippocampus-dependent memory deficits. Apoptotic death are regulated by oxidative In present work, we studied involvement signaling pathway regulation redox after To this end, used malpar1 knockout (KO) wild-type mice assigned either stress (21 days restraint,...
The role of lysophosphatidic acid (LPA) in the control emotional behavior remains to be determined. We analyzed effects central administration 1-oleoyl-LPA (LPA 18∶1) rats tested for food consumption and anxiety-like depression-like behaviors. For this purpose, elevated plus-maze, open field, Y maze, forced swimming intake tests were performed. In addition, c-Fos expression dorsal periaqueductal gray matter (DPAG) was also results revealed that LPA 18∶1 reduced time arms plus-maze induced...