A5026872340- Adenosine and Purinergic Signaling
- BRCA gene mutations in cancer
- Autophagy in Disease and Therapy
- Nutrition, Genetics, and Disease
- Plant and soil sciences
- Adipose Tissue and Metabolism
- Banana Cultivation and Research
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- Pharmaceutical Economics and Policy
- Renin-Angiotensin System Studies
- Regional Development and Innovation
- Alkaline Phosphatase Research Studies
- Genomic variations and chromosomal abnormalities
- Endoplasmic Reticulum Stress and Disease
- Latin American rural development
- Liver Disease Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Ferroptosis and cancer prognosis
- Global trade, sustainability, and social impact
- Liver Diseases and Immunity
- Vascular Anomalies and Treatments
- Signaling Pathways in Disease
- Oil and Gas Production Techniques
- Urbanism, Landscape, and Tourism Studies
Advanced Center for Chronic Diseases
2015-2025
Pontificia Universidad Católica de Chile
2016-2025
University of Chile
2004-2022
CGIAR
2021
Universidad Mayor
2021
Fondazione Umberto Di Mario
2017
Zamorano Pan-American Agricultural School
2012-2014
Centro de Estudios Científicos
2010
Sorbonne Université
2008
Hospital César Milstein
2001
Interleukin-6 (IL-6) is an important myokine that highly expressed in skeletal muscle cells upon exercise. We assessed IL-6 expression response to electrical stimulation (ES) or extracellular ATP as a known mediator of the excitation-transcription mechanism muscle. examined whether canonical signaling cascade downstream (IL-6/JAK2/STAT3) also responds cell excitation, concluding influences its own through positive loop. Either ES exogenous (100 μM) increased both and p-STAT3 levels rat...
Background The renin-angiotensin system (RAS) plays a pivotal role in regulating blood volume, systemic vascular resistance, and electrolyte balance, serving as key component of cardiovascular health. Recent findings highlight the angiotensin II (Ang II) inducing autophagy through receptor type 1 (AT1R). Autophagy, process self-degradation turnover cellular components, is homeostatic response that eliminates superfluous materials. Abnormal promotes cardiomyocyte loss critical hypertrophy...
Bone integrity depends on a finely tuned balance between bone synthesis by osteoblasts and resorption osteoclasts. The secretion capacity of mature requires strict control proteostasis. Endoplasmic reticulum-associated degradation (ERAD) prevents the accumulation unfolded ER proteins via dislocation to cytosol proteasome. membrane protein, homocysteine-inducible endoplasmic reticulum protein with ubiquitin-like domain 1 (HERPUD1), is key component ERAD multiprotein complex which helps...
BRCA1 gene mutations account for nearly all families with multiple cases of both early onset breast and/or ovarian cancer and about 30% hereditary cancer.Although to date more than 1,237 distinct mutations, polymorphisms, variants have been described, several found be recurrent in this gene.We analyzed 63 Chilean breast/ovarian eighteen frequent mutations.The analysis the five exons two introns which these are located was made using mismatch PCR assay, ASO hybridization restriction fragment...
Abstract Hypertension is associated with high circulating angiotensin II (Ang II). We have reported that autophagy regulates Ang II‐induced vascular smooth muscle cell (VSMC) hypertrophy, but the mechanism mediating this effect still unknown. Therefore, we studied how LC3 levels in VSMCs and whether Bag3, a co‐chaperone known to regulate total levels, may be involved effects elicited by II. A7r5 line or rat aortic (RASMC) primary culture were stimulated 100 nM for 24 h I, Bag3 protein...
Breast cancer is the most common malignancy among women, and second cause of mortality Chilean women. Female due to breast in Chile has shown a steady increase from 9.5 deaths per 100.000 women 1985 12.8 1995. A family history one main risk factors for development disease. BRCA1 BRCA2 are two major hereditary susceptibility genes. Mutations these genes associated inherited cancer; 664 predisposing mutations have been described, but specific populations only some them, such as 185delAG found...
Between the year 2010 and 2012, University of Cadiz Regional Government (Junta de Andalucía) have developed archaeological activities in zone outside hispano-roman city, frame General Project Research titled "The maritime economy halieutic Baelo Claudia". We are presenting this paper first results, which allowed to identify existence a western suburbium between riverbed so called "arroyo las Villas", beach necropolis, whose remains been confirmed by geophysical techniques. Inside area few...
Breast cancer is the most common malignancy among women. Chilean studies reveal that this presents third highest mortality rate. A family history of breast one major risk factors for development disease. BRCA1 and BRCA2 are two main hereditary susceptibility genes, mutations in these genes related to inherited cancer. In specific populations only some have been found be associated with susceptibility. The purpose study was establish frequency 5382insC (BRCA1) 6174delT (BRCA2) germline 382...
IL6 is a myokine expressed by skeletal muscle cells upon exercise; the mechanisms regulating this process are poorly understood. IP3-dependent calcium signals involved in expression and mediated extra-cellular ATP. has both positive negative loops its through activation of regulators as SOCS processes STAT3. Rat myotubes were electrically stimulated (ES, 45 Hz, 400 pulses) SOCS3 was followed RT-PCR. pSTAT3 levels detected immunoblot. ELISA allowed detection culture medium. ES increased early...