A5015292787- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Zoonotic diseases and public health
- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- Reproductive Physiology in Livestock
- Chemokine receptors and signaling
- Endometriosis Research and Treatment
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Immune Response and Inflammation
- Hemoglobinopathies and Related Disorders
- Animal Disease Management and Epidemiology
- Pregnancy and preeclampsia studies
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- Hepatitis C virus research
- Vitamin D Research Studies
- vaccines and immunoinformatics approaches
Universidade Federal do Rio Grande do Sul
2016-2025
Universidade Federal do Rio Grande
2008-2024
Universidade de Caxias do Sul
2023
Universidade Federal do Pampa
2023
Santa Casa Hospital
2023
Fundação Getulio Vargas
2023
Universidade do Vale do Rio dos Sinos
2022
Weatherford College
2022
Hospital de Clínicas de Porto Alegre
2008-2022
Universidade do Estado do Rio de Janeiro
2019-2022
The transmission of pathogens from wild animals to humans is called "zoonotic spillover". Most human infectious diseases (60-75%) are derived that originally circulated in non-human animal species. This demonstrates spillover has a fundamental role the emergence new diseases. Understanding factors facilitate essential establish strategies focused on reduction frequency events. In this context, article describes basic aspects zoonotic and main involved events, considering inter-species...
Background: Despite the involvement of cytokine production in neurotrauma, there is still controversy regarding cytokines levels and clinical outcome following severe traumatic brain injury (TBI).Objective: The present study was designed to investigate whether (of IL-1β, IL-6, IL-8, IL-10, IL-12p70 TNF-α) are associated with primary (death or survival) after TBI.Methods: This prospective enrolled 24 male patients, victims TBI. Venous blood samples were taken Intensive Care Unit (ICU) (study...
The ongoing COVID-19 pandemic has caught the attention of global community and rekindled debate about our ability to prevent manage outbreaks, epidemics, pandemics. Many alternatives are suggested address these urgent issues. Some them quite interesting, but with little practical application in short or medium term. To realistically control infectious diseases, human, animal, environmental factors need be considered together, based on One Health perspective. In this article, we highlight...
Psychological stress may affect up to 18% of all pregnant women, altering the function both neuroendocrine and immune systems. Distress conditions directly change hypothalamic-pituitary-adrenal (HPA) axis, leading increased cortisol levels associated changes in cellular immunity. events such as high levels, anxiety or depression indirectly pregnancy thus lead pre-eclampsia (PE). Here, we suggest that distress during development PE by enhancing vivo levels. High are with hypertension...
Vitamin D deficiency has been described in systemic lupus erythematosus (SLE). BsmI VDR (vitamin receptor) gene polymorphism was associated with SLE Asian patients. Studies Brazilian populations have not realized. A case-control study 195 patients and 201 healthy controls conducted to investigate the influence of FokI polymorphisms on susceptibility SLE. In addition, 25-hydroxyvitamin [25(OH)D] measured evaluate possible associations polymorphic variants clinical laboratory expressions...
Human leukocyte antigen-G (HLA-G) is a nonclassical class I major histocompatibility complex molecule which induced at the course of inflammatory pathologies, and its expression has been suggested as possible mechanism tissue protection against autoimmune responses, therefore acting immune surveillance. We investigated influence 14 bp polymorphism HLA-G gene on systemic lupus erythematosus (SLE) by analyzing 293 patients with SLE 460 healthy controls. The patient's group was not in...
Despite its well known monogenic etiopathogenesis, sickle cell disease (SCD) is characterized by a striking variability of clinical presentation. There growing evidence that genetic factors may be involved in this variability. Human leukocyte antigen (HLA)-G non-classical HLA molecule which was shown to expressed at sites inflammation and inflammatory diseases. Besides large highly polymorphic promoter region, the 3' UTR region seems also play an important role on regulating HLA-G...
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease and can affect several organs systems. It characterized by high production of autoantibodies against nuclear compounds. TLR7/8/9 are responsible for nucleic acid recognition they trigger proinflammatory responses through activation NK-kappaB Type I IFN production, making bridge between the innate adaptative immune We analyzed frequency TLR7 rs179008, TLR8 rs3764880, TLR9 rs5743836 rs352140 in 370 patients with...
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease that affects several organs and systems. Its etiology remains unknown, although it probably multifactorial. The human leukocyte antigen G (HLA‐G) a nonclassic major histocompatibility complex I molecule characterized by restricted expression low DNA polymorphism. HLA‐G plays role in immunosuppression through different mechanisms. In diseases, has been postulated may be possible mechanism of tissue protection against...