Carmen Saenz
A5059011264- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Intelligent Tutoring Systems and Adaptive Learning
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Microbial Natural Products and Biosynthesis
- Microscopic Colitis
- Genomics and Phylogenetic Studies
Novo Nordisk Foundation
2021-2023
University of Copenhagen
2021-2023
Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative systematically document links between metabolome (meta)genome data, aiding identification of natural product biosynthetic origins structures.
Clostridioides difficile infection (CDI) is a major health concern and one of the leading causes hospital-acquired diarrhea in many countries. C. challenging to treat as resistant multiple antibiotics. Alternative solutions are needed conventional treatment with broad-spectrum antibiotics often leads recurrent CDI. Recent studies have shown that specific microbiota-based therapeutics such bile acids (BAs) promising approaches Clostridium scindens encodes acid-induced (bai) operon carries out...
Omics technologies have revolutionized microbiome research allowing the characterization of complex microbial communities in different biomes without requiring their cultivation. As a consequence, there has been great increase generation omics data from metagenomes and metatranscriptomes. However, pre-processing analysis these limited by availability computational resources, bioinformatics expertise standardized workflows to obtain consistent results that are comparable across studies. Here,...
Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling is a major challenge, which can be addressed using in vitro fermentors hosting complex microbial communities. Here, by employing 16S rRNA gene amplicon sequencing, we investigated the adaptation and succession human fecal communities an automated multistage fermentor. We performed two independent experiments different donor...