A5031384619- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Marine Sponges and Natural Products
- Metal Extraction and Bioleaching
- Identification and Quantification in Food
- Chemical Synthesis and Analysis
- Microbial Metabolic Engineering and Bioproduction
- Synthesis and Biological Evaluation
- Fungal Biology and Applications
- Cancer therapeutics and mechanisms
- Metabolomics and Mass Spectrometry Studies
- Date Palm Research Studies
- Synthesis of β-Lactam Compounds
- Enzyme Production and Characterization
- Chemical synthesis and alkaloids
Scripps Institution of Oceanography
2020-2025
University of California, San Diego
2020-2025
Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative systematically document links between metabolome (meta)genome data, aiding identification of natural product biosynthetic origins structures.
Ten representative actinobacterial strains isolated from marine sediments collected worldwide were studied to determine their taxonomic status. The previously identified as members of the genus Salinispora and shared >99 % 16S rRNA gene sequence similarity three currently recognized species. Comparative genomic analyses resulted in delineation six new species based on average nucleotide identity digital DNA–DNA hybridization values below 95 70 %, respectively. status groups was supported...
While specialized metabolites are thought to mediate ecological interactions, the evolutionary processes driving chemical diversification, particularly among closely related lineages, remain poorly understood. Here, we examine dynamics governing distribution of natural product biosynthetic gene clusters (BGCs) 118 strains representing all nine currently named species marine actinobacterial genus Salinispora. much attention has been given role horizontal transfer (HGT) in structuring BGC...
Pseudopeptides are attractive agents for protease inhibition due to their structural similarities the natural substrates of these enzymes, as well enhanced stability and resistance enzymatic degradation. We report three new ketomemicin pseudopeptides (1–3) from extracts marine actinomycete Salinispora pacifica strain CNY-498. Their constitution relative configuration were elucidated using NMR, mass spectrometry, quantum chemical calculations. Using GNPS molecular networking publicly...
The Ojo de Liebre Lagoon is a Marine Protected Area that lies within UNESCO World Heritage Site and critical habitat for important migratory species such as the grey whale bird species. Unique hypersaline environments, Lagoon, are underexplored in terms of their bacterial chemical diversity, representing potential source new bioactive compounds with pharmacological properties. Actinobacteria one most diverse prolific taxonomic groups marine compounds. This study aimed to identify culturable...
Five new members of the salinilactone family, salinilactones D-H, are reported. These bicyclic lactones produced by Salinispora bacteria and display extended or shortened alkyl side chains relative to recently reported A-C. They were identified GC/MS, gas chromatographic retention index, comparison with synthetic samples. We further investigated occurrence across six newly proposed species gain insight into how compound production varies among taxa. The growth-inhibiting effect this family...
ABSTRACT While specialized metabolites are thought to mediate ecological interactions, the evolutionary processes driving their diversification, particularly among closely related lineages, remain poorly understood. Here, we examine dynamics governing distribution of natural product biosynthetic gene clusters (BGCs) using 118 strains within marine actinomycete genus Salinispora . previous evidence indicated that horizontal transfer (HGT) largely contributed BGC diversity, find a majority...
ABSTRACT We report three new ketomemicin pseudopeptides ( 1 – 3 ) from extracts of the marine actinomycete Salinispora pacifica strain CNY-498. Their constitution and relative configuration were elucidated using NMR, mass spectrometry, quantum chemical calculations. Using GNPS molecular networking publicly available LCMS datasets, five additional analogs 4 8 identified with production detected broadly across species. The biosynthetic gene cluster ktm is highly conserved in , occurring 79 118...
Abstract Marine microbial communities govern many of the biological and chemical processes in ocean, including element cycles, ecosystem health, disease. organisms are surrounded by microbes complex molecular interactions occur between bacterial symbionts, eukaryotic hosts, their pathogens or prey. Trace metals ocean can be either beneficial detrimental to marine life depending on concentrations bioavailability. Multiple tunicate species known bioaccumulate trace mantel, research suggests...