Gloria I. Giraldo-Calderón
A5048192579- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Genomics and Phylogenetic Studies
- Neurobiology and Insect Physiology Research
- Genetics, Bioinformatics, and Biomedical Research
- Trypanosoma species research and implications
- Invertebrate Immune Response Mechanisms
- Molecular Biology Techniques and Applications
- Viral Infections and Vectors
- Atomic and Subatomic Physics Research
- Insect Resistance and Genetics
- Forensic Entomology and Diptera Studies
- Research on Leishmaniasis Studies
- Evolution and Genetic Dynamics
- Species Distribution and Climate Change
- Parasite Biology and Host Interactions
- Forest Insect Ecology and Management
- Biomedical Text Mining and Ontologies
- Parasites and Host Interactions
- Insect Pest Control Strategies
- CRISPR and Genetic Engineering
- Genomics and Rare Diseases
- Scarabaeidae Beetle Taxonomy and Biogeography
- Viral Infectious Diseases and Gene Expression in Insects
- Computational Physics and Python Applications
Icesi University
2019-2023
University of Notre Dame
2014-2023
Vector (United States)
2018
Purdue University West Lafayette
2012-2017
Michigan State University
2016
University of Georgia
2015
Virginia Tech
2015
European Bioinformatics Institute
2015
Wellcome Trust
2015
University of Pennsylvania
2015
VectorBase is a National Institute of Allergy and Infectious Diseases supported Bioinformatics Resource Center (BRC) for invertebrate vectors human pathogens. Now in its 11th year, currently hosts the genomes 35 organisms including number non-vectors comparative analysis. Hosted data range from genome assemblies with annotated gene features, transcript protein expression to population genetics variation insecticide-resistance phenotypes. Here we describe improvements our resource set tools...
Abstract Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of tick, Ixodes scapularis (Say), which vectors that cause Lyme disease, human granulocytic anaplasmosis, babesiosis diseases. The large reflects accumulation repetitive DNA, new lineages retro-transposons, gene architecture patterns resembling ancient metazoans rather pancrustaceans. Annotation scaffolds representing ∼57% genome, reveals 20,486 protein-coding genes...
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) represents the 2019 merger of VectorBase with EuPathDB projects. As a Bioinformatics Center funded by National Institutes Health, additional support from Welllcome Trust, VEuPathDB supports >500 organisms comprising invertebrate vectors, eukaryotic pathogens (protists fungi) relevant free-living or non-pathogenic species hosts. Designed to empower researchers access Omics data...
Rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is major vector Chagas disease, an illness that affects approximately seven million people worldwide. We sequenced genome R. prolixus, generated assembled sequences covering 95% (∼ 702 Mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses this obligate blood-feeding insect. Although immune-deficiency (IMD)-mediated immune responses were observed,...
Abstract Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni . With World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize genome glabrata, lophotrochozoan protostome, and provide timely important information biology. We describe aspects phero-perception, stress responses, immune function regulation gene expression that support...
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) is a Bioinformatics Center funded by the National Institutes of Health with additional funding from Wellcome Trust. VEuPathDB supports >600 organisms that comprise invertebrate vectors, eukaryotic pathogens (protists fungi) relevant free-living or non-pathogenic species hosts. Since 2004, has analyzed omics data public domain using contemporary bioinformatic workflows, including...
Phlebotomine sand flies are of global significance as important vectors human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites genus Leishmania , causative agents devastating diseases collectively termed leishmaniasis. More than 40 pathogenic species transmitted to humans by approximately 35 fly in 98 countries with hundreds millions people at risk around world. No approved efficacious vaccine exists for leishmaniasis available...
Many neglected tropical infectious diseases affecting humans are transmitted by arthropods such as mosquitoes and ticks. New mode-of-action chemistries urgently sought to enhance vector management practices in countries where arthropod-borne endemic, especially populations have acquired widespread resistance insecticides.We describe a "genome-to-lead" approach for insecticide discovery that incorporates the first reported chemical screen of G protein-coupled receptor (GPCR) mined from...
High throughput sequencing has accelerated the determination of genome sequences for thousands human infectious disease pathogens and dozens their vectors. The scale scope these data are enabling genotype-phenotype association studies to identify genetic determinants pathogen virulence drug/insecticide resistance, phylogenetic track origin spread outbreaks. To maximize utility genomic purposes, it is essential that metadata about pathogen/vector isolate characteristics be collected made...
Abstract Arthropods play a dominant role in natural and human-modified terrestrial ecosystem dynamics. Spatially-explicit arthropod population time-series data are crucial for statistical or mathematical models of these dynamics assessment their veterinary, medical, agricultural, ecological impacts. Such have been collected world-wide over century, but remain scattered largely inaccessible. In particular, with the ever-present growing threat pests vectors infectious diseases, there numerous...
Opsins are light sensitive receptors associated with visual processes. Insects typically possess opsins that stimulated by ultraviolet, short and long wavelength (LW) radiation. Six putative LW-sensitive predicted in the yellow fever mosquito, Aedes aegypti malaria Anopheles gambiae, eight southern house Culex quinquefasciatus, suggest gene expansion Family Culicidae (mosquitoes) relative to other insects. Here we report first detailed molecular evolutionary analyses of LW three mosquito...
In Cali, Colombia, catch basins (streetside storm drains) are one of the main larval habitats Aedes aegypti and Culex quinquefasciatus. Since 1999, these mosquitoes have been controlled by Secretaría de Salud Municipal (Secretary Public Health) using larvicide triflumuron. Because high densities that remain in city, treatment failure was suspected -possibly insecticide resistance target species.The efficacy triflumuron VectoMax (biorational mixture Bacillus thuringiensis var. israelensis...
Abstract Motivation: RNA-Seq is a method for profiling transcription using high-throughput sequencing and an important component of many research projects that wish to study transcript isoforms, condition specific expression transcriptional structure. The methods, tools technologies used perform analysis continue change, creating bioinformatics challenge researchers who exploit these data. Resources bring together genomic data, tools, educational material computational infrastructure can...
Aedes aegypti is the primary mosquito vector of several human arboviruses, including dengue virus (DENV). Vector control principal intervention to decrease transmission these viruses. The characterization molecules involved in physiological responses blood-feeding may help identify novel targets useful designing effective strategies. In this study, we evaluated vivo effect feeding adult female mosquitoes with red blood cells reconstituted either heat-inactivated (IB) or normal plasma (NB)....
Abstract Arthropods play a dominant role in natural and human-modified terrestrial ecosystem dynamics. Spatially-explicit population time-series are crucial for statistical or mathematical models of these dynamics assessment their veterinary, medical, agricultural, ecological impacts. Arthropod data have been collected world-wide over century, but remain scattered largely inaccessible. With the ever-present growing threat arthropod vectors infectious diseases pest species, there enormous...
Aedes aegypti is the primary mosquito vector of several human arboviruses including dengue virus (DENV). Vector control principal intervention to decrease transmission these viruses. The characterization molecules involved in physiological responses blood-feeding may help identify novel targets useful design effective strategies. In this study, we evaluated vivo effect feeding adult female mosquitoes with blood containing either heat-inactivated (IB), normal serum (NB), and RNA-seq based...
ABSTRACT Motivation: RNA-Seq is a method for profiling transcription using high-throughput sequencing and an important component of many research projects that wish to study transcript isoforms, condition specific expression, transcriptional structure. The methods, tools, technologies employed perform analysis continue change, creating bioinformatics challenge researchers who exploit these data. Resources bring together genomic data, educational material, computational infrastructure can...
We report the first record of Culex (Anoedioporpa) restrictor collected from a tree hole in Cauca Valley, Colombia, 2006.