A5024028369- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Invertebrate Immune Response Mechanisms
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Chronic Myeloid Leukemia Treatments
- Cancer-related Molecular Pathways
- Protein Kinase Regulation and GTPase Signaling
- Physiological and biochemical adaptations
- Chronic Lymphocytic Leukemia Research
- Helminth infection and control
- Biological Research and Disease Studies
University of New Mexico
2010-2023
Abstract Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni . With World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize genome glabrata, lophotrochozoan protostome, and provide timely important information biology. We describe aspects phero-perception, stress responses, immune function regulation gene expression that support...
The c-Myb transcription factor is a critical regulator of proliferation and stem cell differentiation, mutated alleles are oncogenic, but little known about changes in activity during the cycle. To map association with specific target genes cycle, we developed novel Fix-Sort-ChIP approach, which asynchronously growing cells were fixed formaldehyde, stained Hoechst 33342 separated into different cycle fractions by flow sorting, then processed for chromatin immunoprecipitation (ChIP) assays....
The parasitic flatworm Schistosoma mansoni, causative agent of human intestinal schistosomiasis in South America, relies importantly on the freshwater snail Biomphalaria glabrata as intermediate host to achieve development cercariae that infect humans. recommendation from World Health Organization (WHO) integrate control efforts counter transmission provides impetus for depth study B. biology. Our analysis indicates two distinct hemocyanin-like genes (hcl-1 and hcl-2) are present glabrata, a...
ABSTRACT The egg mass fluid (EMF) of the freshwater snail Biomphalaria glabrata (Hygrophila: Planorbidae) contains haemocyanin-like 1 (Hcl-1) protein, distinct from respiratory haemocyanins. distribution Hcl-1 was investigated among major families Hygrophila, Physidae and Lymnaeidae, both which employ haemocyanins, Planorbidae, a group that evolved haemoglobin as pigment. Immunoblotting detected c. 150 kDa protein (molecular weight Hcl-1) cross-reactive with anti-keyhole limpet haemocyanin...
Abstract The c-Myb transcription factor is a critical regulator of proliferation and stem cell differentiation, mutated alleles are oncogenic, but little known about the activities during cycle. Previous studies showed that interacts with cycle regulators Cyclin D1 Dependent Kinases 4 6, suggesting activity regulated We set out to test directly, using Chromatin ImmunoPrecipitation (ChIP) assays capable assessing in primary flow sorted populations cells. performed ChIP cells into each phase...