A5063103223- Growth Hormone and Insulin-like Growth Factors
- Genomics and Phylogenetic Studies
- Glycosylation and Glycoproteins Research
- Estrogen and related hormone effects
- Genetics, Bioinformatics, and Biomedical Research
- Ovarian cancer diagnosis and treatment
- Microbial Metabolites in Food Biotechnology
- Mosquito-borne diseases and control
- Malaria Research and Control
- Insect symbiosis and bacterial influences
- Trypanosoma species research and implications
- Cancer-related molecular mechanisms research
- Wheat and Barley Genetics and Pathology
- Gene expression and cancer classification
- Mycorrhizal Fungi and Plant Interactions
- Hypothalamic control of reproductive hormones
- Parasitic Infections and Diagnostics
- Vector-borne infectious diseases
- Evolution and Genetic Dynamics
- Protein Kinase Regulation and GTPase Signaling
- Plant Pathogens and Fungal Diseases
- Parasitic Diseases Research and Treatment
- Bird parasitology and diseases
- Plant Pathogens and Resistance
- 3D Printing in Biomedical Research
University of Georgia
2010-2023
University of Pennsylvania
2012
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) represents the 2019 merger of VectorBase with EuPathDB projects. As a Bioinformatics Center funded by National Institutes Health, additional support from Welllcome Trust, VEuPathDB supports >500 organisms comprising invertebrate vectors, eukaryotic pathogens (protists fungi) relevant free-living or non-pathogenic species hosts. Designed to empower researchers access Omics data...
FungiDB (fungidb.org) is a free online resource for data mining and functional genomics analysis fungal oomycete species. part of the Eukaryotic Pathogen Genomics Database Resource (EuPathDB, eupathdb.org) platform that integrates genomic, transcriptomic, proteomic, phenotypic datasets, other types pathogenic nonpathogenic, free-living parasitic organisms. one largest EuPathDB databases containing nearly 100 genomes obtained from GenBank, Aspergillus Genome (AspGD), The Broad Institute,...
The Eukaryotic Pathogen Genomics Database Resource (EuPathDB, http://eupathdb.org) is a collection of databases covering 170+ eukaryotic pathogens (protists & fungi), along with relevant free-living and non-pathogenic species, select pathogen hosts. To facilitate the discovery meaningful biological relationships, couple preconfigured searches visualization analysis tools for comprehensive data mining via intuitive graphical interfaces APIs. All are analyzed same workflows, including creation...
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) is a Bioinformatics Center funded by the National Institutes of Health with additional funding from Wellcome Trust. VEuPathDB supports >600 organisms that comprise invertebrate vectors, eukaryotic pathogens (protists fungi) relevant free-living or non-pathogenic species hosts. Since 2004, has analyzed omics data public domain using contemporary bioinformatic workflows, including...
Parasitic diseases caused by kinetoplastid parasites are a burden to public health throughout tropical and subtropical regions of the world. TriTrypDB ( https://tritrypdb.org ) is free online resource for data mining genomic functional from these part VEuPathDB Bioinformatics Resource Center https://veupathdb.org ). As release 59, hosts 83 genomes, nine which, including Trypanosoma brucei TREU927, cruzi CL Brener Leishmania major Friedlin, undergo manual curation integrating information...
EuPathDB (http://eupathdb.org) resources include 11 databases supporting eukaryotic pathogen genomic and functional data, isolate data phylogenomics. are built using the same infrastructure provide a sophisticated search strategy system enabling complex interrogations of underlying data. Recent advances in design implementation new loading workflow, database Piroplasmida (i.e. Babesia Theileria), addition large amounts types incorporation analysis tools. New genome sequences annotation,...
Epithelial ovarian tumours exhibit a range of malignant potential, presenting distinct clinical phenotypes. Improved knowledge gene expression changes and functional pathways associated with these phenotypes may lead to new treatment targets, markers for early detection better understanding disease progression. Gene profiling (Affymetrix, U95Av2) was carried out on 18 including benign adenomas, borderline adenocarcinomas low potential adenocarcinomas. Clustering the profiles samples from...
Since a substantial percentage of ovarian cancers express gonadotropin receptors and are responsive to the relatively high concentrations pituitary gonadotropins during postmenopausal years, it has been suggested that receptor activation may contribute etiology and/or progression neoplasm. The goal present study was develop cell model determine impact luteinizing hormone (LH) (LHR) expression LH-mediated LHR on gene thus obtain insights into mechanism action surface epithelial (OSE)...
Kra monkeys (Macaca fascicularis), a natural host of Plasmodium knowlesi, control parasitaemia caused by this parasite species and escape death without treatment. Knowledge the disease progression resilience in kra will aid effective use to study mechanisms malaria. This longitudinal aimed define clinical, physiological pathological changes infected with P. which could explain their resilient phenotype.
Abstract The effects of luteinizing hormone (LH), a gonadotropic implicated in the development ovarian cancer, are mediated by specific binding to its G protein–coupled receptor, LH receptor (LHR). Activated LHR initiates second messenger responses, including cyclic AMP (cAMP) and inositol phosphate. Because cAMP increases expression ErbB-2, tyrosine kinase whose overexpression cancers correlates with poor survival, we hypothesized that may regulate ErbB-2 expression. Cell surface stable...
Abstract Plasmodium cynomolgi causes zoonotic malarial infections in Southeast Asia and this parasite species is important as a model for vivax ovale . Each of these produces hypnozoites the liver, which can cause relapsing blood. Here we present methods data generated from iterative longitudinal systems biology infection experiments designed performed by Malaria Host-Pathogen Interaction Center (MaHPIC) to delve deeper into biology, pathogenesis, immune responses P. Macaca mulatta host....
<div>Abstract<p>The effects of luteinizing hormone (LH), a gonadotropic implicated in the development ovarian cancer, are mediated by specific binding to its G protein–coupled receptor, LH receptor (LHR). Activated LHR initiates second messenger responses, including cyclic AMP (cAMP) and inositol phosphate. Because cAMP increases expression ErbB-2, tyrosine kinase whose overexpression cancers correlates with poor survival, we hypothesized that may regulate ErbB-2 expression. Cell...
<div>Abstract<p>The effects of luteinizing hormone (LH), a gonadotropic implicated in the development ovarian cancer, are mediated by specific binding to its G protein–coupled receptor, LH receptor (LHR). Activated LHR initiates second messenger responses, including cyclic AMP (cAMP) and inositol phosphate. Because cAMP increases expression ErbB-2, tyrosine kinase whose overexpression cancers correlates with poor survival, we hypothesized that may regulate ErbB-2 expression. Cell...