A5105024336- Mosquito-borne diseases and control
- Malaria Research and Control
- Invertebrate Immune Response Mechanisms
- Trypanosoma species research and implications
- Glycosylation and Glycoproteins Research
- Gestational Diabetes Research and Management
- Insect symbiosis and bacterial influences
- Insect Pest Control Strategies
- Viral Infections and Vectors
- Research on Leishmaniasis Studies
- Diabetes and associated disorders
- Insect and Pesticide Research
- Galectins and Cancer Biology
- Virology and Viral Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Parasites and Host Interactions
- RNA regulation and disease
- Bariatric Surgery and Outcomes
- Melanoma and MAPK Pathways
- Cardiovascular and Diving-Related Complications
- Insect-Plant Interactions and Control
- Phytochemical Studies and Bioactivities
- T-cell and Retrovirus Studies
- melanin and skin pigmentation
- Biotechnology and Related Fields
Fundação Oswaldo Cruz
2014-2025
Universidade do Estado do Amazonas
2018-2023
Fundação de Medicina Tropical
2016-2023
Universidade Federal do Amazonas
2021
Universidade de São Paulo
2018
Escola Superior de Ciências da Saúde
2018
Instituto do Câncer do Estado de São Paulo
2018
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
National Institute of Allergy and Infectious Diseases
2016
National Institutes of Health
2016
Asymptomatic individuals are one of the major challenges for malaria elimination programs in endemic areas. In absence clinical symptoms and with a lower parasite density they constitute silent reservoirs considered important maintaining transmission human malaria. Studies from Brazil have shown that infected may carry these parasites long periods. Patients were selected three periurban areas city Manaus, western Brazilian Amazon. Symptomatic asymptomatic patients positive thick blood smear...
Malaria is transmitted when an infected mosquito delivers Plasmodium sporozoites into a vertebrate host. There are many species of and, in general, the infection host-specific. For example, gallinaceum avian parasite, while berghei infects mice. These two parasites have been extensively used as experimental models malaria transmission. falciparum and vivax most important agents human malaria, life-threatening disease global importance. To complete their life cycle, must traverse midgut form...
Abstract Background We investigated the association between maternal neutralizing antibodies (nAb) to Zika virus (ZIKV) in pregnancy and neonatal outcomes. Methods In pregnant participants with confirmed ZIKV infection, we determined trimester of collected sera longitudinally, measured nAbs via plaque reduction. neonates, adverse outcomes included microcephaly (MC), structural brain abnormalities (SBA), hearing, eye abnormalities. Associations nAbs, were analyzed Cox regression. Results...
We analyzed the development of Leishmania ( ) infantum chagasi in its natural sandfly vector Lutzomyia longipalpis . In addition, we compared infections initiated with axenic amastigotes or promastigotes. Our data showed no important difference between Lu. infection rates resulting from either type infections. Furthermore, was equivalent both cases. All promastigote forms were found inside and, after blood digestion, most population consisted procyclics and nectomonads. A low percentage...
Whole mitogenome sequences (mtDNA) have been exploited for insect ecology studies, using them as molecular markers to reconstruct phylogenies, or infer phylogeographic relationships and gene flow. Recent Anopheles phylogenomic studies provided information regarding the time of deep lineage divergences within genus. Here we report complete 15,393 bp mtDNA aquasalis, a Neotropical human malaria vector. When comparing its structure base composition with other relevant available anopheline...
Abstract Malaria is a severe public health problem in several developing tropical and subtropical countries . Anopheles aquasalis the primary coastal malaria vector Central South America Caribbean Islands, it has peculiar feature of living water with large changes salinity. Recent research recognised An. as an important model for studying interactions murine human Plasmodium parasites. This study presents complete genome offers insights into its evolution physiology. The similar size gene...
Dengue virus (DENV) and Zika (ZIKV) belong to the same viral family, Flaviviridae. They cause recurring threats public health systems of tropical countries such as Brazil. The primary Brazilian vector both viruses is mosquito Aedes aegypti. After ingests a blood meal from an infected person, infect replicate in midgut, disseminate secondary tissues reach salivary gland (SG), where they are ready be transmitted vertebrate host. It thought that intrinsic discrepancies among mosquitoes could...
Reducing mosquito abundance or interfering with its ability to support the parasite cycle can help interrupt malaria in areas of significant risk transmission. Fluralaner is a safe and effective drug for veterinary use indicated treatment against fleas ticks which acts as an antagonist chloride ion channels mediated by γ-aminobutyric acid (GABA), preventing entry these ions into postsynaptic neuron, leading hyperexcitability neuron central nervous system arthropods. demonstrated insecticidal...
Malaria is endemic in the American continent and Amazonian rainforest region with highest risk of transmission. However, lack suitable experimental models to infect malaria vectors from Americas has limited progress understand biology transmission this region. Anopheles aquasalis, a major vector coastal areas South America, was found be highly refractory infection two strains Plasmodium falciparum (NF54 7G8) berghei (mouse malaria), even when microbiota eliminated antibiotics oxidative...
Anophelines are vectors of malaria, the deadliest disease worldwide transmitted by mosquitoes. The availability genomic data from various Anopheles species allowed evolutionary comparisons immune response genes in search alternative vector control malarial parasites. Now, with aquasalis genome, it was possible to obtain more information about evolution genes. has 278 24 families or groups. Comparatively, American anophelines possess fewer than gambiaes.s., most dangerous African vector....
The identification of a 32-bp deletion in the cc-chemokine receptor-5 gene (CCR5delta32 allele) that renders homozygous individuals highly resistant to HIV infection has prompted worldwide investigations frequency CCR5delta32 allele regional populations. It is important ascertain if factor be considered overall epidemiology individual With this mind we determined large sample (907 individuals) southeastern Brazilian urban population, stratified as follows: 322 healthy unrelated individuals,...
Eukaryotic initiation factor 5A (eIF5A) is a conserved protein with an essential role in translation elongation. Using one and two-dimensional western blotting, we showed that the eIF5A level was 2-fold lower benznidazole (BZ)-resistant (BZR 17LER) Trypanosoma cruzi populations than their respective susceptible counterparts (BZS 17WTS). To confirm of BZ resistance, transfected BZS 17WTS wild-type or mutant eIF5A-S2A (in which serine 2 replaced by alanine). Upon overexpressing eIF5A, both...
Abstract Gangliosides are sialic acid-containing glycosphingolipids located mainly in outlet membrane plasma. Tumors usually accumulate gangliosides as disialoganglioside GD3 which is widely expressed melanomas and neuroblastomas. has been associated with tumor progression, conferring tumorigenic characteristics to cells such increased proliferation migration. In order investigate the role of cell migration, we have transfected synthase gene (ST8Sia I) a melanocyte line. this work...