A5052095247- Genetic Associations and Epidemiology
- Forensic and Genetic Research
- Extracellular vesicles in disease
- Muscle metabolism and nutrition
- MicroRNA in disease regulation
- Bone health and osteoporosis research
- Genetics and Physical Performance
- Race, Genetics, and Society
- Cardiovascular and exercise physiology
- Body Composition Measurement Techniques
- Muscle Physiology and Disorders
- Genetic diversity and population structure
- Vitamin D Research Studies
- Sports Performance and Training
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Genetic and phenotypic traits in livestock
- Circular RNAs in diseases
- Genomic variations and chromosomal abnormalities
- Chronic Myeloid Leukemia Treatments
- dental development and anomalies
- Physical Education and Gymnastics
- Peanut Plant Research Studies
Universidade Católica de Brasília
2014-2024
Baylor College of Medicine
2022
Universidade de Brasília
2012-2020
Universidade Católica Dom Bosco
2016
Universidade Federal de Mato Grosso do Sul
2016
Universidade Federal de Minas Gerais
2000-2007
Obesity is a multifactor disease associated with cardiovascular disorders such as hypertension. Recently, gut microbiota was linked to obesity pathogenesisand shown influence the host metabolism. Moreover, several factors host-genotype and life-style have been modulate composition. Exercise well-known agent used for treatment of numerous pathologies, hypertension; it has recently demonstrated shape consortia. Since exercise-altered could possibly improve diseases related dysfunctional...
Human facial diversity is substantial, complex, and largely scientifically unexplained. We used spatially dense quasi-landmarks to measure face shape in population samples with mixed West African European ancestry from three locations (United States, Brazil, Cape Verde). Using bootstrapped response-based imputation modeling (BRIM), we uncover the relationships between variation effects of sex, genomic ancestry, a subset craniofacial candidate genes. The these variables are summarized as...
Ancestry informative SNPs can be useful to estimate individual and population biogeographical ancestry. Brazilian is characterized by a genetic background of three parental populations (European, African, Native Amerindians) with wide degree diverse patterns admixture. In this work we analyzed the information content 28 ancestry-informative into multiplexed panels using sources (African, Amerindian, European) infer admixture in an urban sample five geopolitical regions. The assigned apart...
Worldwide, diseases are important reducers of peanut (Arachis hypogaea) yield. Sources resistance against many available in cultivated genotypes, although often not farmer preferred varieties. Wild species generally harbor greater levels and even apparent immunity, the linkage agronomically un-adapted wild alleles with disease genes is inevitable. Marker-assisted selection has potential to facilitate combination both loci adapted alleles. However, there an almost complete lack knowledge...
Pregnancy success results from the interaction of multiple factors, among them are folliculogenesis and early embryonic development. Failure during these different processes can lead to difficulties in conception. Alternatives overcome problems based on assisted reproductive techniques. Extracellular vesicles cell-secreted present body fluids contain bioactive materials, such as messenger RNA, microRNAs (miRNAs), proteins. Thus, our hypothesis is that extracellular follicular fluid 3–6 mm...
Physical exercise stimulates organs, mainly the skeletal muscle, to release a broad range of molecules, recently dubbed exerkines. Among them, RNAs, such as miRNAs, piRNAs, and tRNAs loaded in extracellular vesicles (EVs) have potential play significant role way muscle other organs communicate translate into health. Low, moderate high intensity treadmill protocols were applied rat groups, aiming investigate impact on serum EVs their associated small RNA molecules. Transmission electron...
Arachis hypogaea (peanut) is an important crop worldwide, being mostly used for edible oil production, direct consumption and animal feed. Cultivated peanut allotetraploid species with two different genome components, A B. Genetic linkage maps can greatly assist molecular breeding genomic studies. However, the development of A. difficult because it has very low levels polymorphism. This be overcome by utilization wild Arachis, which present A- B-genomes in diploid state, show high genetic...
A current concern in genetic epidemiology studies admixed populations is that population stratification can lead to spurious results. The Brazilian census classifies individuals according self-reported "color", but several have demonstrated stratifying "color" not a useful strategy control for structure, due the dissociation between and genomic ancestry. We report results of study group siblings which we measured skin pigmentation using reflectometer, estimated ancestry 21 Ancestry...
Context: Circulating miRNAs are potential biomarkers that can be important molecules driving cell-to-cell communication.Objective: To investigate circulating muscle-specific in recreational athletes.Materials and methods: Three from whole plasma before after a half-marathon were analyzed by qPCR.Results: MiR-1, −133a, −206 significantly increased the race.Discussion: Increased levels of exercise point to possibility being functional players following endurance training.Conclusion: These...
There is an active search for the ideal strategy to potentialize effects of Mesenchymal Stem-Cells (MSCs) over immune system. Also, part scientific community seeking elucidate therapeutic potential MSCs secretome and its extracellular vesicles (EVs), in order avoid complexity a cellular therapy. Here, we investigate human adipose (AMSCs) licensing with INF-γ TLR3 agonist AMSCs proliferation, migration, as well immunomodulatory function. Furthermore, evaluated how affected function AMSC...
Background: Population stratification is the main source of spurious results and poor reproducibility in genetic association findings. heterogeneity can be controlled for by grouping individuals ethnic clusters; however, admixed populations, there evidence that such proxies do not provide efficient control. The aim this study was to evaluate relation self-reported with ancestry statistical risk an sample based on ancestry.Methods: A questionnaire included item completed 189 female volunteers...
Blood carries a wide array of biomolecules, including nutrients, hormones, and molecules that are secreted by cells for specific biological functions. The recent finding stable RNA both endogenous exogenous origin in circulation raises number questions opens broad, new field: exploring the origins, functions, applications these extracellular molecules. These findings raise many important questions, including: what mechanisms export cellular uptake, is nature source their stability, do they...
In recent decades, the role played by extracellular vesicles in physiological and pathological processes has attracted attention. Extracellular are released different types of cells carry molecules that could become biomarkers for diagnosis diseases. also moldable tools controlled release bioactive substances clinical therapeutic applications. However, one significant challenges when studying these exciting versatile is purification process, which presents difficulties terms lack purity,...
This study examined the association between ACE I/D and ACTN3 R577X polymorphisms muscle-related phenotypes their adaptation to resistance training in older women. Volunteers (n=246;age=66.7±5.5 years) underwent quadriceps strength assessment using isokinetics fat-free mass by dual energy X-ray absorptiometry. 79 volunteers performed 24 weeks of 75 were studied as controls. Genotypes identified standard procedures. No associations observed for muscle either gene, but carrying D/D genotype...
Genetic disorders of the skeleton comprise a large group more than 450 clinically distinct and genetically heterogeneous diseases associated with mutations in 300 genes. Achieving definitive diagnosis is complicated due to genetic heterogeneity these disorders, their individual rarity diverse radiographic presentations. We used targeted exome sequencing designed 1.4Mb panel for simultaneous testing 4,800 exons 309 genes involved skeletal disorders. DNA from 69 individuals 66 families known...
Abstract Background Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing migratory capacity as well potentializing immune response suppression are of interest. GvHD management, preventing opportunistic infections is also a valuable strategy, since immunocompromised patients easy targets infections. LL-37 host defense peptide (HDP) that has been deeply investigated due to its immunomodulatory function. In...
Background: Alzheimer's disease (AD) is the most common form of dementia worldwide, and bears remarkable evidence for a differential prevalence among continental populations. In this scenario, estimating ancestry proportions in recently admixed populations strategy that can help increasing knowledge about genetic structure complex trait. Aim/Methods: Our purpose was to assess mean estimates three main parental contributors Brazilian contingent (European, African Amerindian) using panel 12...
The relationship between vitamin D receptor (VDR) ApaI, CDX2, BsmI, FokI, and TaqI polymorphisms fat-free mass (FFM) were examined in 191 postmenopausal Brazilian women (mean age 67.87 ± 5.22 years). Participants underwent FFM measurements by dual-energy x-ray absorptiometry (DEXA). Whole-blood-extracted genomic DNA was genotyped to the aforementioned ancestry-informative markers through minisequencing, using SNaPshot Multiplex System. Association VDR variables assessed analysis of...
The role played by genetic components in the etiology of Class III phenotype, a class dental malocclusion, is not yet understood. Regions that may be related to development malocclusion have been suggested previously. aim this study was search for linkage with 6 microsatellite markers (D1S234, D4S3038, D6S1689, D7S503, D10S1483, and D19S566), near previously proposed candidate regions III. We performed two-point parametric analysis 42 affected individuals from 10 Brazilian families positive...
Exercise is a non-pharmacologic agent widely used for hypertension control, where low intensity often associated with blood pressure reduction. Maximal lactate steady state (MLSS) was recently identified in spontaneously hypertensive rats (SHRs) as an important step establishing secure intensities prescribing exercise phenotypes. Here we verified the effects of training around MLSS, 20% below and 15% above MLSS on aerobic fitness status SHR. Eighteen-week-old SHRs (n = 5, ~ 172.4 ± 8.1 mm Hg...
The radiological accident in Goiania 1987 caused a trail of human contamination, animal, plant and environmental by radionuclide. Exposure to ionizing radiation results different types DNA lesions. mutagenic effects on the germline are special concern because they can endures for several generations, leading an increase rate mutations children irradiated parents. Thus, evaluate biological mechanisms somatic cells, with consequent determination mutations, is extremely important estimation...