A5050145701- Forensic and Genetic Research
- Race, Genetics, and Society
- Genetic diversity and population structure
- Forensic Anthropology and Bioarchaeology Studies
- Protease and Inhibitor Mechanisms
- Digestive system and related health
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Global Maritime and Colonial Histories
- Genetic and phenotypic traits in livestock
- Language and cultural evolution
- melanin and skin pigmentation
- Molecular Biology Techniques and Applications
- Linguistic Variation and Morphology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Machine Learning in Bioinformatics
- Erythrocyte Function and Pathophysiology
- Skin Protection and Aging
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- Advanced Proteomics Techniques and Applications
- African history and culture studies
- Evolution and Genetic Dynamics
- Calpain Protease Function and Regulation
- Malaria Research and Control
Universidade do Porto
2014-2024
Instituto Português de Oncologia Francisco Gentil
2024
The Quebec Population Health Research Network
2023
Centro de Investigação em Biodiversidade e Recursos Genéticos
2012-2023
Instituto Superior de Educação e Ciências
2018
Instituto Superior de Ciências de Educação à Distância
2018
Universidad de Manizales
2014
IPO Porto
1999-2013
Institute of Molecular Pathology and Pathomorphology
2011
University of Bologna
2008
This work was undertaken to ascertain what degree the physical appearance of a Brazilian individual predictive genomic African ancestry. Using panel 10 population-specific alleles, we assigned each person an ancestry index (AAI). The procedure able tell apart, with no overlaps, 20 males from northern Portugal São Tomé Island on west coast Africa. We also tested Amerindians and observed that their AAI values fell in same range as Europeans. Finally, studied two different population samples....
Human facial diversity is substantial, complex, and largely scientifically unexplained. We used spatially dense quasi-landmarks to measure face shape in population samples with mixed West African European ancestry from three locations (United States, Brazil, Cape Verde). Using bootstrapped response-based imputation modeling (BRIM), we uncover the relationships between variation effects of sex, genomic ancestry, a subset craniofacial candidate genes. The these variables are summarized as...
This article presents a probability table for the evaluation of stress values generated by multidimensional scaling (MDS) procedures employing formula 1. is based on distribution from 587,200 random similarity matrices different sizes processed to yield results several dimensions.
The population of Brazil, formed by extensive admixture between Amerindians, Europeans and Africans, is one the most variable in world. We have recently published a study that used ancestry-informative markers to conclude at an individual level, color, as determined physical evaluation, was poor predictor genomic ancestry, estimated molecular markers. To corroborate these findings we undertook present investigation based on data from 12 commercially available forensic microsatellites were...
Variation in human skin and eye color is substantial especially apparent admixed populations, yet the underlying genetic architecture poorly understood because most genome-wide studies are based on individuals of European ancestry. We study pigmentary variation 699 from Cape Verde, where extensive West African/European admixture has given rise to a broad range trait values genomic ancestry proportions. develop apply new approach for measuring color, identify two major loci (HERC2[OCA2] P =...
The inverse correlation between skin pigmentation and latitude observed in human populations is thought to have been shaped by selective pressures favoring lighter facilitate vitamin D synthesis regions far from the equator. Several candidate genes for shown exhibit patterns of polymorphism that overlap geospatial variation color. However, little work has focused on estimating time frame over which changed intensity selection acting different genes. To provide a temporal framework evolution...
Current information about the expansion of Bantu-speaking peoples is hampered by scarcity genetic data from well identified populations southern Africa. Here, we fill an important gap in analysis western edge Bantu migrations studying for first time patterns Y-chromosome, mtDNA and lactase persistence variation four representative groups living around Namib Desert southwestern Angola (Ovimbundu, Ganguela, Nyaneka-Nkumbi Kuvale). We assessed differentiation between these their levels...
While gene flow between distantly related populations is increasingly recognized as a potentially important source of adaptive genetic variation for humans, fully characterized examples are rare. In addition, the role that natural selection resistance to vivax malaria may have played in extreme distribution protective Duffy-null allele, which nearly completely fixed mainland sub-Saharan Africa and absent elsewhere, controversial. We address both these issues by investigating evolution allele...
Abstract Objectives : We investigated the frequency distribution and haplotype diversity of human African trypanosomiasis (HAT) resistance lactase persistence (LP) variants in populations from Angolan Namib to trace spread these genetic adaptations into southwestern Africa. Materials Methods resequenced two fragments LCT enhancer APOL1 gene genotyped flanking short tandem repeat loci six groups with different subsistence traditions living Namib, a comparative dataset including other Africa...
The Transatlantic Slave Trade transported more than 9 million Africans to the Americas between early 16th and mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations infer how different African groups contributed North-, South-American, Caribbean populations, in context of geographic geopolitical factors, compared genetic data with demographic history records Trade. observed that West-Central Africa Western Africa-associated ancestry clusters are...
Abstract The expansion of people speaking Bantu languages is the most dramatic demographic event in Late Holocene Africa and fundamentally reshaped linguistic, cultural biological landscape continent 1–7 . With a comprehensive genomic dataset, including newly generated data modern-day ancient DNA from previously unsampled regions Africa, we contribute insights into this that started 6,000–4,000 years ago western Africa. We genotyped 1,763 participants, 1,526 speakers 147 populations across...
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant susceptibility syndrome characterized by early-onset (DGC) and lobular breast cancer. E-cadherin (CDH1) heterozygous germline mutations deletions are found in 40% of families. Independent CDH1 alterations, most HDGC tumours display mislocalized or absent immunoexpression, therefore undetected defects at the locus may still be involved. We aimed determining whether mutation-negative probands allele-specific expression (ASE)...
The study of Y chromosome variation has helped reconstruct demographic events associated with the spread languages, agriculture, and pastoralism in sub-Saharan Africa, but little attention been given to early history continent. In order overcome this lack knowledge, we carried out a phylogeographic analysis haplogroups A B broad data set populations. These two lineages are particularly suitable for objective because they most deeply rooted branches genealogy. Their distribution is almost...
Bantu speech communities expanded over large parts of sub-Saharan Africa within the last 4000-5000 years, reaching different southern 1200-2000 years ago. The languages subdivide in several major branches, with belonging to Eastern and Western branches spreading Central, Eastern, Southern Africa. There is still debate whether this linguistic divide correlated a genetic distinction between speakers. During their expansion, speakers would have come into contact diverse local populations, such...
The Bantu expansion, which started in West Central Africa around 5,000 BP, constitutes a major migratory movement involving the joint spread of peoples and languages across sub-Saharan Africa. Despite rich linguistic archaeological evidence available, genetic relationships between different Bantu-speaking populations routes they followed during various phases expansion remain poorly understood. Here, we analyze profiles southwestern southeastern located at edges by generating genome-wide...
Quilombo remnants are relics of communities founded by runaway or abandoned African slaves, but often with subsequent extensive and complex admixture patterns European Native Americans. We combine a genetic study Y-chromosome markers anthropological surveys in order to obtain portrait quilombo structure history the region that has largest number state São Paulo.Samples from 289 individuals were genotyped using set 17 microsatellites on Y chromosome (AmpFlSTR-Yfiler). A subset 82 samples was...
Considerando a crescente importância da humanização no cuidado à saúde, especialmente contexto Medicina Família e Comunidade, observa-se que implementação de práticas humanizadas enfrenta desafios significativos, como sobrecarga dos profissionais deficiência na infraestrutura das unidades resistência abordagens centradas paciente. Objetiva-se, neste trabalho, analisar os principais as estratégias eficazes para promover do cuidado, destacando acolhimento, envolvimento comunitário utilização...