A5079615184- Research on Leishmaniasis Studies
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Insect and Pesticide Research
- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Oral health in cancer treatment
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Phenothiazines and Benzothiazines Synthesis and Activities
- Radiomics and Machine Learning in Medical Imaging
- Wound Healing and Treatments
- Immune cells in cancer
- Photodynamic Therapy Research Studies
- Helicobacter pylori-related gastroenterology studies
- Medicine and Dermatology Studies History
- Immune Response and Inflammation
- Hematopoietic Stem Cell Transplantation
- Genetics and Neurodevelopmental Disorders
- Head and Neck Cancer Studies
- Reproductive tract infections research
- Eosinophilic Esophagitis
- Colorectal Cancer Surgical Treatments
Universidade de São Paulo
2013-2019
Clinics Hospital of Ribeirão Preto
2016-2019
Lunenfeld-Tanenbaum Research Institute
2018-2019
Mount Sinai Hospital
2018-2019
University of Toronto
2018
Universidade de Ribeirão Preto
2013-2016
Fundação Hemopa
2016
Auxilio Mutuo Hospital
2014
Faculdade de Medicina de São José do Rio Preto
2014
Fundação Oswaldo Cruz
2012
Abstract Background and Objective Cutaneous mucocutaneous leishmaniasis are diseases characterized by skin or mucosal manifestations. In the new world, Leishmania braziliensis is main etiological agent of cutaneous leishmaniasis, condition that may evolve to form. The therapeutic arsenal routinely employed treat infected patients unsatisfactory, especially for pentavalent antimonials, treatment recommended WHO, as they often highly toxic, poorly tolerated variable effectiveness. This work...
Few microhabitats have been previously identified as natural breeding places for phlebotomine sand flies so far, and little is known about the influence of climate variables in their density. The present study was conducted a dry region with semiarid climate, where visceral leishmaniasis occurs humans dogs. occurrence specific investigated soil samples collected from five houses, which were also location used sampling adults. All sampled by our due to immature forms flies. On weekly basis,...
Abstract Background Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing migratory capacity as well potentializing immune response suppression are of interest. GvHD management, preventing opportunistic infections is also a valuable strategy, since immunocompromised patients easy targets infections. LL-37 host defense peptide (HDP) that has been deeply investigated due to its immunomodulatory function. In...
PLK4 is a cell cycle-regulated kinase important for the biogenesis of centrioles and known to be synthetically lethal with TRIM37 gene amplification. Previous attempts inhibit have been hampered by selectivity or ADME liabilities. The inhibitor Centrinone B, while potent selective, metabolically unstable lacks oral bioavailability. Assisted structure-based drug design (SBDD), dramatic improvements in potency, properties were made this structure, resulting identification RP-1664, an excellent...
By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma (ECCs) are two of the most widely used human pluripotent model cell lines, sharing several characteristics, including expression miRNAs associated to state with differentiation. However, how each these functionally impacts properties has not been systematically evaluated. We investigated effects 31 on...
Head and neck squamous cell carcinoma (HNSCC) is among the most common cancer types. Metastasis, main cause of death by cancer, can be promoted an inflammatory microenvironment, which induces epithelial-mesenchymal transition (EMT) through a NF-kB-mediated stabilization Snail. Here, we aimed to explore how microRNAs (miRs) affect survival EMT in HNSCC cells under microenvironment. By using high-content screening (HCS) approach, evaluated alterations morphometric parameters, as well...
Leishmaniasis, a protozoan parasitic disease that remains major worldwide health problem with high endemicity in developing countries. Treatment of cutaneous Leishmaniasis (CL) should be decided by the clinical lesions, etiological species and its potential to develop into mucosal Leishmaniasis. High cost, systemic toxicity, diminished efficacy due development parasite resistance are serious drawbacks current treatment options. Thus, identifying new, effective, safer anti-leishmanial drug(s)...
Abstract Background Postoperative Crohn’s disease (CD) recurs in ~70% of patients ≤1 year following ileocolonic resection (ICR), as observed endoscopically. Current understanding molecular determinants underlying histological intestinal inflammation with postoperative CD recurrence is minimal. To address this issue, we used advanced spatial transcriptomic analyses on biopsy samples matched and endoscopic assessments from neoterminal ileum, anastomosis, colon who had undergone colonoscopy...
Leishmaniasis is a complex disease that affects more than 12 million people in 88 countries worldwide. Leishmania (Viannia) braziliensis the most common species Americas and important causative agent of cutaneous mucocutaneous leishmaniasis Brazil. The therapeutic arsenal routinely employed to treat patients with limited unsatisfactory. For leishmaniasis, pentavalent antimonials are first line scheme recommended by WHO. These compounds highly toxic, poorly tolerated their effectiveness...
Abstract Like many solid cancers, in head and neck cancers (HNC) the presence of metastases is a well-known prognostic factor associated with worst survival. Studies to date indicate that chronic stimulation tumor necrosis alpha (TNF-α) has potential enhance several cell characteristics, such as survival, proliferation, migration, promoting metastasis. It believed TNF-α leads activation different inflammatory pathways, nuclear factor-kappa B (NF-kB) AKT pathway, inhibiting GSK-3β-mediated...